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Volumn 3, Issue 11, 2004, Pages 1143-1144

Irofulven: Resurgence for alkylating therapy in cancer?

Author keywords

Alkylating agent; Bcl 2; Ionizing radiation; p53; Post mitotic; Signaling; Survival

Indexed keywords

6 HYDROXYMETHYLACYLFULVENE; ALKYLATING AGENT; IROFULVEN; UNCLASSIFIED DRUG; PROTEIN BCL 2; SESQUITERPENE;

EID: 22144446452     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.11.1306     Document Type: Note
Times cited : (5)

References (10)
  • 2
    • 1642293264 scopus 로고    scopus 로고
    • NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven
    • Dick RA, Yu X, Kensler TW. NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven. Clin Cancer Res 2004; 10:1492-9.
    • (2004) Clin Cancer Res , vol.10 , pp. 1492-1499
    • Dick, R.A.1    Yu, X.2    Kensler, T.W.3
  • 3
    • 0037816582 scopus 로고    scopus 로고
    • Marked activity of irofulven toward human carcinoma cells: Comparison with cisplatin and ecteinascidin
    • Poindessous V, Koeppel F, Raymond E, Comisso M, Waters SJ, Larsen AK. Marked activity of irofulven toward human carcinoma cells: comparison with cisplatin and ecteinascidin. Clin Cancer Res 2003; 9:2817-25.
    • (2003) Clin Cancer Res , vol.9 , pp. 2817-2825
    • Poindessous, V.1    Koeppel, F.2    Raymond, E.3    Comisso, M.4    Waters, S.J.5    Larsen, A.K.6
  • 6
    • 4143100263 scopus 로고    scopus 로고
    • Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells
    • Koeppel F, Poindessous V, Lazar V, Raymond E, Sarasin A, Larsen AK. Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells. Clin Cancer Res 2004; 10:5604-13.
    • (2004) Clin Cancer Res , vol.10 , pp. 5604-5613
    • Koeppel, F.1    Poindessous, V.2    Lazar, V.3    Raymond, E.4    Sarasin, A.5    Larsen, A.K.6
  • 7
    • 0036248530 scopus 로고    scopus 로고
    • Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases
    • Wang W, Waters SJ, MacDonald JR, Roth C, Shentu S, Freeman J, Von Hoff DD, Miller AR. Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases. Anticancer Res 2002; 22:559-64.
    • (2002) Anticancer Res , vol.22 , pp. 559-564
    • Wang, W.1    Waters, S.J.2    MacDonald, J.R.3    Roth, C.4    Shentu, S.5    Freeman, J.6    Von Hoff, D.D.7    Miller, A.R.8
  • 10
    • 0033819653 scopus 로고    scopus 로고
    • Targeting apoptosis by hydroxymethylacylfulvene in combination with gamma radiation in prostate tumor cells
    • Woynarowska BA, Roberts K, Woynarowski JM, MacDonald JR, Herman TS. Targeting apoptosis by hydroxymethylacylfulvene in combination with gamma radiation in prostate tumor cells. Radiat Res 2000; 154:429-38.
    • (2000) Radiat Res , vol.154 , pp. 429-438
    • Woynarowska, B.A.1    Roberts, K.2    Woynarowski, J.M.3    MacDonald, J.R.4    Herman, T.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.