Increased genotoxic susceptibility of breast epithelial cells to ethylene oxide

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 585, Issue 1-2, 2005, Pages 120-126

  Ádám, Balázs ^a   Bárdos, Helga ^a   Ádány, Róza ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Breast cancer; Comet assay; DNA damage; Ethylene oxide; Genotoxicity

Indexed keywords

ETHYLENE OXIDE;

ARTICLE; BIOLOGICAL MONITORING; BREAST EPITHELIUM; CELL CULTURE; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; KERATINOCYTE; LYMPHOBLAST; LYMPHOCYTE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; UTERINE CERVIX EPITHELIUM;

BREAST; CELLS, CULTURED; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; ETHYLENE OXIDE; FEMALE; HELA CELLS; HUMANS; KERATINOCYTES; LYMPHOCYTES; MUTAGENS; ORGAN SPECIFICITY;

EID: 22144441356     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2005.04.009     Document Type: Article

References (26)

1. International Agency for Research on Cancer, IARC, Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 60, Some industrial chemicals, IARC, Lyon, 1994
2. J. Nygren, B. Cedervall, S. Eriksson, M. Dušinká, and A. Kolman Induction of DNA strand breaks by ethylene oxide in human diploid fibroblasts Environ. Mol. Mutagen. 24 1994 161 167
3. M.E. Herrero, M. Arand, J.G. Hengstler, and F. Oesch Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide, but not from ethylene oxide-induced DNA strand breaks Environ. Mol. Mutagen. 30 1997 429 439
4. A. Kolman, T. Bohušová, B. Lambert, and J.W.M. Simons Induction of 6-thioguanine-resistant mutants in human diploid fibroblasts in vitro with ethylene oxide Environ. Mol. Mutagen. 19 1992 93 97
5. A. Kolman, and M. Chovanec Combined effects of γ-radiation and ethylene oxide in human diploid fibroblasts Mutagenesis 15 2000 99 104
6. E. Agurell, H. Cederberg, L. Ehrenberg, K. Lindahl-Kiessling, U. Rannug, and M. Törnqvist Genotoxic effects of ethylene oxide and propylene oxide: a comparative study Mutat. Res. 250 1991 229 237
7. N.J. van Sittert, P.J. Boogaard, A.T. Natarajan, A.D. Tates, L.G. Ehrenberg, and M.A. Törnqvist Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment Mutat. Res. 447 2000 27 48
8. C.L. Garcia, F. Darroudi, A.D. Tates, and A.T. Natarajan Induction and persistence of micronuclei, sister-chromatid exchanges and chromosomal aberrations in splenocytes and bone-marrow cells of rats exposed to ethylene oxide Mutat. Res. 492 2001 59 67
9. J. Fuchs, U. Wullenweber, J.G. Hengstler, H.G. Bienfait, G. Hiltl, and F. Oesch Genotoxic risk for humans due to work place exposure to ethylene oxide: remarkable individual differences in susceptibility Arch. Toxicol. 68 1994 343 348
10. J. Major, G.M. Jakab, and A. Tompa Genotoxicological investigation of hospital nurses occupationally exposed to ethylene oxide. I. Chromosome aberrations, sister-chromatid exchanges, cell cycle kinetics, and UV-induced DNA synthesis in peripheral blood lymphocytes Environ. Mol. Mutagen. 27 1996 84 92
11. P.D. Stolley, K.A. Soper, S.M. Galloway, W.W. Nichols, S.A. Norman, and S.R. Wolman Sister-chromatid exchanges in association with occupational exposure to ethylene oxide Mutat. Res. 129 1984 89 102
12. J. Mayer, D. Warburton, A.M. Jeffrey, R. Pero, S. Walles, L. Andrews, M. Toor, L. Latriano, L. Wazneh, D. Tang, W.-Y. Tsai, M. Kuroda, and F. Perera Biologic markers in ethylene oxide exposed workers and controls Mutat. Res. 248 1991 63 176
13. D.W. Lynch, T.R. Lewis, W.J. Moorman, J.R. Burg, D.H. Groth, A. Khan, L.J. Ackerman, and B.Y. Cockrell Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats Toxicol. Appl. Pharmacol. 76 1984 69 84
14. S.A. Norman, J.A. Berlin, K.A. Spoer, B.F. Middendorf, and P.D. Stolley Cancer incidence in a group of workers potentially exposed to ethylene oxide Int. J. Epidemiol. 24 1995 276 283
15. C. Högstedt, N. Malmqvist, and B. Wadman Leukemia in workers exposed to ethylene oxide JAMA 241 1979 1132 1133
16. C. Högstedt, L. Aringer, and A. Gustavsson Epidemiologic support for ethylene oxide as a cancer-causing agent JAMA 255 1986 1575 1578
17. L. Hagmar, Z. Mikoczy, and H. Welinder Cancer incidence in Swedish sterilant workers exposed to ethylene oxide Occup. Environ. Med. 52 1995 154 156
18. K. Steenland, E. Whelan, J. Deddens, L. Stayner, and E. Ward Ethylene oxide and breast cancer incidence in a cohort of 7576 women (United States) Cancer Causes Control 14 2003 531 539
19. K. Steenland, L. Stayer, and J. Deddens Mortality analyses in a cohort of 18 235 ethylene oxide exposed workers: follow up extended from 1987 to 1988 Occup. Environ. Med. 61 2004 2 7
20. K. Steenland, L. Stayner, A. Greife, W. Halperin, R. Hayes, R. Hornung, and S. Nowlin Mortality among workers exposed to ethylene oxide N. Engl. J. Med. 324 1991 1402 1407
21. E. Müller, and A. Bertók Az egri kórházban elofordult daganatos megbetegedések - higiénés viszonyok, konzekvenciák Kórház- és Orvostechnika 33 1995 17 22 (in Hungarian)
22. A. Tompa, J. Major, and M.G. Jakab Is breast cancer cluster influenced by environmental and occupational factors among hospital nurses in Hungary? Pathol. Oncol. Res. 5 1999 117 121
23. L. Kardos, Gy. Széles, Gy. Gombköto, M. Szeremi, A. Tompa, and R. Ádány Cancer death among hospital staff potentially exposed to ethylene oxide: an epidemiological analysis Environ. Mol. Mutagen. 42 2003 59 60
24. A. Böyum Separation of lymphocytes from blood and bone marrow Scand. J. Clin. Lab. Invest. 21 1968 51 76
25. J.G. Hengstler, J. Fuchs, S. Gebhard, and F. Oesch Glycolaldehyde causes DNA-protein crosslinks: a new aspect of ethylene oxide genotoxicity Mutat. Res. 304 1994 229 234
26. R.P. Beliles, and J.C. Parker Risk assessment and oncodynamics of ethylene oxide as related to occupational exposure Toxicol. Ind. Health 3 1987 371 382