In vitro evaluation of the effect of the opioid antagonist N-methylnaltrexone on motility of the equine jejunum and pelvic flexure

Equine Veterinary Journal

Volumn 37, Issue 4, 2005, Pages 325-328

  Van Hoogmoed, L M ^a   Boscan, P L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Horse; Intestine; Morphine; Motility; Naltrexone

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

EID: 22144433375     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/0425164054529346     Document Type: Conference Paper

References (31)

1. Bagnol, D., Mansour, A. and Akil, H. (1997) Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neurosci. 81, 579-591.
2. Bennett, R.C. and Steffey, E.P. (2002) Use of opioids for pain and anesthetic management in horses. Vet. Clin. N. Am.: Equine Pract. 18, 47-60.
3. Bittar, K.N. and Makhlouf, G.M. (1982) Receptors on smooth muscle cells: characterization by contraction and specific antagonists. Am. J. Physiol. 242, G400-G407.
4. Brown, D.R. and Goldberg, L.I. (1985) The use of quaternary narcotic antagonists in opiate research. Neuropharmacol. 24, 181-191.
5. Burks, T.F. (1987) Actions of drugs on gastrointestinal motility. In: Physiology of the Gastrointestinal Tract, Vol. 1, Ed: L.R. Johnson, Raven Press, New York, pp 723-743.
6. Combie, J., Schultz, T. and Nugent, E.G. (1981) Pharmacology of narcotic analgesics in the horse: selective blockade of narcotic-induced locomotor activity. Am. J. vet. Res. 42, 716-721.
7. DeLuca, A. and Coupar, I.M. (1996) Insights into opioid action in the intestinal tract. Phamacol. Ther. 69, 103-115.
8. Goodrich, L.R., Nixon, A.J., Fubuni, S.L., Ducharme, N.G., Fortier, L.A., Warnick, L.D. and Ludders, J.W. (2002) Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopy. Vet. Surg. 31, 232-239.
9. Kohn, C.W. and Muir, W.W. (1988) Selected aspects of the clinical pharmacology of visceral analgesics and gut motility modifying drugs in the horse. J. vet. intern. Med. 2, 85-91.
10. Kosterlitz, H.W. and Waterfield, A.A. (1972) Differential effects of drugs on the acetylcholine output from the myenteric plexus and the responses of the longitudinal muscle of the guinea-pig ileum. Br. J. Pharmacol. 46, 569-570.
11. Kurz, A. and Sessler, D.I. (2003) Opioid-induced bowel dysfunction, pathophysiology and potential new therapies. Drugs 63, 649-671.
12. Manaka, H., Manaka, Y., Kostolanska, F., Fox-Threlkeld, J.E.T. and Daniel, E.E. (1989) Release of VIP and substance P from isolated perfused canine ileum. Am. J. Physiol. 257, G182-G190.
13. Mircica, E., Cluttone, R.E., Kyles, K.W. and Blissitt, K.J. (2003) Problems associated with perioperative morphine in horses: a retrospective case analysis. Vet. Anaesth. Analg. 30, 147-155.
14. Muir, W.W., Skarda, R.T. and Sheehan, W.C. (1978) Cardiopulmonary effects of narcotic agonists and a partial agonist in horses. Am. J. vet. Res. 29, 1632-1635.
15. Muir, W.W., Skarda, R.T. and Sheehan, W.C. (1979) Hemodynamic and respiratory effects of xylazine-morphine sulfate in horses. Am. J. vet. Res. 40, 1417-1420.
16. Natalini, C.C. and Robinson, E.P. (2000) Evaluation of the analgesic effects of epidurally administered morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. Am. J. vet. Res. 61, 1579-1586.
17. North, R.A. (1979) Opiates, opioid peptides and single neurons. Life Sci. 24, 1527-1546.
18. Reisine, T. and Pasternak, G. (1996) Opioid analgesics and antagonists. In: Goodman and Gilman's: The Pharmacologic Basis of Therapeutics, 9th edn., Eds: J.G. Hardman and L.E. Limbird, Pergamon Press, New York, pp 521-556.
19. Roberts, M.C. and Argenzio, A. (1986) Effects of amitraz, several opiate derivatives and anticholinergic agents on intestinal transit in ponies. Equine vet. J. 18, 256-260.
20. Roger, T.H., Bardon, T.H. and Ruckenbusch, Y. (1985) Colonic motor responses in the pony: relevance of colonic stimulation by opiate antagonists. Am. J. vet. Res. 46, 31-35.
21. Shook, J.E., Pelton, J.T., Hruby, V.J. and Burks, T.F. (1987) Peptide opioid antagonist separates peripheral and central opioid antitransit effects. J. Pharmacol. expt. Ther. 243, 492-500.
22. Stephenson, J. (2002) Methylnaltrexone reverses opioid-induced constipation. Lancet Oncol. 3, 202-203.
23. Sysel, A.M., Pleasant, R.S., Jacobson, J.D., Moll, H.D., Modransky, P.D. and Warnich, L.D. (1996) Efficacy of an epidural combination of morphine and detomidine in alleviating experimentally induced hindlimb lameness in horses. Vet. Surg. 25, 511-518.
24. Taguchi, A., Sharma, N., Saleem, R.M., Sessler, D.I., Carpenter, R.L., Seyedsadr, M. and Durz, A. (2001) Selective postoperative inhibition of gastrointestinal opioid receptors. New Engl. J. Med. 345, 935-940.
25. van Hoogmoed, L.M., Snyder, J.R. and Harmon, F. (2000) In vitro investigation of the effect of prostaglandins and nonsteroidal anti-inflammatory drugs on contractile activity of the equine smooth muscle of the dorsal colon, ventral colon, and pelvic flexure. Am. J. vet. Res. 61, 1259-1266.
26. Wood, J.D. and Galligan, J.J. (2004) Function of opioids in the enteric nervous system. Neurogastroenerol. Motil., Suppl. 16, 17-28.
27. Youn, S.C. and Billings, J.A. (2002) Opioid antagonists, a review of their role in palliative care, focusing on use in opioid-related constipation. J. Pain. Symptom Management 24, 71-90.
28. Yuan, C.-S. (2004) Clinical status of methylnaltrexone, a new agent to prevent and manage opioid-induced side effects. J. Support Oncol. 2, 111-222.
29. Yuan, C.-S. and Foss, J.F. (2000) Antagonism of gastrointestinal opioid effects. Reg. Anesth. Pain Med. 25, 639-642.
30. Yuan, C.-S., Foss, J.F. and Moss, J. (1995) Effects of methylnaltrexone on morphine-induced inhibition of contraction in isolated guinea pig ileum and human intestine. Eur. J. Pharmacol. 276, 107-111.
31. Yuan, C.-S., Foss, J.F., O'Connor, M., Toledano, A., Roizen, M.F. and Moss, J. (1996) Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: a double-blind randomized placebo-controlled trail. Clin. Pharmacol. Ther. 59, 469-475.