How much should we involve genetic and environmental factors in the risk assessment of mycotoxins in humans?

International Journal of Environmental Research and Public Health

Volumn 2, Issue 1, 2005, Pages 186-193

  Creppy, Edmond E ^a   Moukha, Serge ^b   Bacha, Hassen ^c   Carratu, Maria Rosaria ^d  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b CEMAGREF   (France)

^c UNIVERSITY OF MONASTIR   (Tunisia)

^d UNIVERSITY OF BARI   (Italy)

Author keywords

B27 35; Environment and genetic factors; HLA haplotype A3; Mycotoxins in humans; Ochratoxin A

Indexed keywords

MYCOTOXIN; OCHRATOXIN;

CONFERENCE PAPER; CORRELATION ANALYSIS; ENVIRONMENT; GENETIC ANALYSIS; HAPLOTYPE; HUMAN; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY TUBULE DISORDER; RISK ASSESSMENT; TUNISIA;

EID: 22044441112     PISSN: 16604601     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph2005010186     Document Type: Conference Paper

References (29)

1. Van der Merwe, K. J.; Steyn, P. S.; Fourie, L.; Scott, D. B.; Theron, J. J.: Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature. 1965, 205, 1112-1113.
2. Creppy, E. E.: Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett. 2002, 127, 19-28.
3. Krogh, P.: Role of ochratoxin in disease causation. Food Chem. Toxicol. 1992, 30, 213-224.
4. Kuiper-Goodman, T.; Scott, P. M.: Risk assessment of the mycotoxin ochratoxin A. Biomed. Environ. Sci., 1989, 2, 179-248.
5. Abid, S.; Hassen, W.; Achour, A.; Skhiri, H.; Maaroufi, K.; Ellouz, F.; Creppy, E.; Bacha, H. Ochratoxin A and human chronic nephropathy in Tunisia: is the situation endemic? Hum. Exp. Tox., 2003, 22, 77-84.
6. McGlynn, K. A.; Hunter, K.; LeVoyer, T.; Roush, J.; Wise, P.; Michielli, R. A.; Shen, F. M.; Evans, A. A.; London, W. T.; Buetow, K. H.: Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans. Cancer Res., 2003, 63, 4594-4601.
7. Hassen, W.; Abid, S.; Achour, A.; Maaroufi, K.; Creppy, E.; Bacha, H.: Ochratoxin A and human nephropathy in Tunisia: a ten year survey. Ann. Toxicol. Anal., 2003, 15, 21-29.
8. Ueno, Y. The toxicology of mycotoxins. Crit. Rev. Toxicol., 1985, 14, 99-132.
9. Creppy, E. E.; Kane, A.; Dirheimer, G.; Lafarge-Frayssinet, C.; Mousset, S.; Frayssinet, C. Genotoxicity of ochratoxin A in mice: DNA single-strand break evaluation in spleen, liver and Kidney. Toxicol. Lett,. 1985, 28, 29-35.
10. Tiemersma, E. W.; Omer, R. E.; Bunschoten, A.; van't Veer, P.; Kok, F. J.; Idris, M. O.; Kadaru, A. M.; Fedail, S. S.; Kampman, E.: Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev., 2001, 10, 785-791.
11. Simarro-Doorten, A. Y.; Bull, S.; van der Doelen, M. A. M.; Fink-Gremmels, J.: Metabolism-mediated cytotoxicity of ochratoxin A. Toxicology in Vitro., 2004, 18, 271-277.
12. Creppy, E. E.; Chiarappa, P.; Baudrimont, I.; Borraci, P.; Moukha, S.; Carratu, M. R.: Synergistic effects of fumonisin B1 and ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity? Toxicology, 2004, 201, 115-123.
13. FAO/WHO Expert Committee on Food Additives, Evaluation of certain mycotoxins in food. Fifty-sixth report of the Joint World Health Organ. Tech. Rep. Ser. 2002; 906, pp. 1-62.
14. Mobio, T.A.; Anane, R.; Baudrimont, I.; Carratu, M.R.; Shier, T.W.; Dano. S.D.; Ueno, Y.; Creppy, E.E. Epigenetic properties of fumonisin B1: cell cycle arrest and DNA base modification in C6 glioma cells. Toxicol Appl Pharmacol., 2000, 164, 91-96.
15. Horvath, A.; Upham, B. L.; Ganev, V.; Trosko, J. E.: Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line. Toxicon., 2002, 40, 273-82.
16. Assaf, H.; Azouri, H.; Pallardy, M.: Ochratoxin A induces apoptosis in human lymphocytes through down regulation of Bcl-xL. Toxicol Sci., 2004, 79, 335-344.
17. Lühe, A.; Hildebrand, H.; Bach, U.; Dingermann, T.; Ahr, H-J.: A new approach to studying ochratoxin A(OTA)-induced nephrotoxicity: expression profiling in vivo and in vitro employing cDNA microarrays. Toxico. Sci., 2003, 73, 315-328.
18. Ouanes, Z.; Abid, S.; Ayed, I.; Anane, R.; Mobio, T.; Creppy, E. E.; Bacha, H.: Induction of micronuclei by zearalenone in Vero monkey kidney cells and in bone marrow cells of mice: protective effect of vitamin E. Mut Res., 2003, 538, 63-70.
19. Stoloff, L.; Van Egmond. H. P.; Park, D. L.: Rationales for the establishment of limits and regulations for mycotoxins in mammals. Food Addit Contam., 1999, 36, 175-181.
20. Pfohl-Leszkowicz, A.; Grosse, Y.; Castegnaro, M.; Nicolov, I. G.; Chernozemsky, I. N.; Bartsch, H.; Betbeder, A. M.; Creppy, E. E.; Dirheimer, G.: Ochratoxin A-related DNA adducts in urinary tract tumours of Bulgarian subjects. IARC Sci Publ., 1993, 124, 141-148.
21. Hassen,W.; Abid, S.; Achour, A.; Creppy, E.; Bacha, H.: Ochratoxin A and ß2-microglobulinuria in healthy individuals and in chronic interstitial nephropathy patients in the centre of Tunisia: a hot spot of Ochratoxin A exposure. Toxicology, 2004, 199, 185-93.
22. Baudrimont, I.; Betbeder, A-M.; Creppy, E. E.: Protective effect of aspartame on the karyomegaly induced by ochratoxin a in rat kidney. Toxicol Lett., 1996, 88, 21-22.
23. Mihatsch, M. J.; Gudat, F.; Zollinger, H. U.; Heierli, C.; Tholen, H.; Reutter, F. W. Systemic karyomegaly associated with chronic interstitial nephritis. A new disease entity? Clin Nephrol., 1979, 12, 54-62
24. Spoendlin, M.; Moch, H.; Brunner, F.; Brunner, W.; Burger, H. R.; Kiss, D.; Wegmann, W.; Dalquen, P.; Oberholzer, M.; Thiel, G.: Karyomegalic interstitial nephritis: further support for a distinct entity and evidence for a genetic defect. Am J Kidney Dis., 1995, 25, 242-252.
25. Godin, M.; Francois, A.; Le Roy, F.; Morin, J. P.; Creppy E. E.; Hemet, J.; Fillastre, J. P.: Karyomegalic interstitial nephritis. Am J Kidney Dis., 1996, 27(1), 166.
26. Hanada, K.; Yewdell, J. W.; Yang, J. C.: Immune recognition of a human renal cancer antigen through post-translational protein splicing. Nature, 2004, 427, 252-256.
27. Morozov, V. N.; Morozova, T.; Bray, P.; Hranisavljevic, J.; Vucelic, D.: Survey of small molecule and ion binding to beta 2-microglobulin - possible relation to BEN. Kidney Int Suppl., 1991, 34, S85-88.
28. Andonova, I. E.; Sarueva, R. B.; Horvath, A. D.; Simeonov, V. A.; Dimitrov, P. S.; Petropoulos, E. A.; Ganev, V. S.: Balkan endemic nephropathy and genetic variants of glutathione S-transferases. J. Nephrol., 2004, 17, 390-398.
29. Gautier, J. P.; Holzhaeuser, D.; Markovic, J.; Germaud, E.; Schilter, B.; Ad Turesky, R. J.: Oxidative damage and stress response from ochratoxin A exposure in rats. Free Radical Biology and Medicine, 2001, 30, 1089-1098.