IL-5 inhibits apoptosis by upregulation of c-myc expression in human hematopoietic cells

Annals of the New York Academy of Sciences

Volumn 1042, Issue , 2005, Pages 481-487

  Juan, Shu Hui ^a   Yen, Jeffrey Jong Young ^b   Lee, Horng Mo ^c   Huang, Huei Mei ^a,c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Anti apoptosis; c myc; IL 5 receptor subunit; Interleukin 5

Indexed keywords

INTERLEUKIN 5; INTERLEUKIN 5 RECEPTOR; LIPOCORTIN 5; MYC PROTEIN; ONCOPROTEIN; PROTEIN C FOS; PROTEIN C JUN; RECEPTOR SUBUNIT; TRANSCRIPTION FACTOR FOSB; TRANSCRIPTION FACTOR JUNB; UNCLASSIFIED DRUG;

APOPTOSIS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL STRAIN JYTF 1; CELL STRAIN TF 1; CELL SURVIVAL; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; ONCOGENE C FOS; ONCOGENE C JUN; ONCOGENE C MYC; PROTO ONCOGENE;

EID: 22044435018     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1338.041     Document Type: Conference Paper

References (13)

1. TAKATSU, K. 1992. Interleukin-5. Curr. Opin. Immunol. 4: 299-306.
2. TAVERNIER, J., R. DEVOS, S. CORNELIS, et al. 1991. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a α chain shared with the receptor for GM-CSF. Cell 66: 1175-1184.
3. TAKAKI, S., H. KANAZAWA, M. SHIIBA, et al. 1994. A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction. Mol. Cell. Biol. 14: 7404-7413.
4. MIGITA, M., N. YAMAGUCHI, S. KATOH, et al. 1990. Elevated expression of protooncogenes during interleukin-5-induced growth and differentiation of murine B lineage cells. Microbiol. Immunol. 34: 937-952.
5. SHAULIAN, E. & M. KARIN. 2001. AP-1 in cell proliferation and survival. Oncogene 20: 2390-2400.
6. PELENGARIS, S. & M. KHAN. 2003. The many faces of c-MYC. Arch. Biochem. Biophys. 416: 129-136.
7. KITAMURA, T., T. TANGE, T. TERASAWA, et al. 1989. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J. Cell. Physiol. 140: 323-334.
8. HUANG, H.M., J.C. LI, Y.C. HSIEH, et al. 1999. Optimal proliferation of a hematopoietic progenitor cell line requires either costimulation with stem cell factor or increase of receptor expression that can be replaced by overexpression of Bcl-2. Blood 93: 2569-2577.
9. HUANG, H.M., C.J. HUANG & J.J. YEN. 2000. Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways. Blood 96: 1764-1771.
10. MATHAS, S., M. HINZ, I. ANAGNOSTOPOULOS, et al. 2002. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. EMBO J. 21: 4104-4113.
11. JIANG, M.R., Y.C. LI, Y. YANG, et al. 2003. c-Myc degradation induced by DNA damage results in apoptosis of CHO cells. Oncogene 22: 3252-3259.
12. WOOD, A.C., C.M. WATERS, A. GARNER & J.A. HICKMAN. 1994. Changes in c-myc expression and the kinetics of dexamethasone-induced programmed cell death (apoptosis) in human lymphoid leukaemia cells. Br. J. Cancer 69: 663-669.
13. SONENSHEIN, G.E. 1997. Down-modulation of c-myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion. J. Immunol. 158: 1994-1997.