Genotoxicity of inhalation anesthetics (halothane, isoflurane and sevoflurane) in human lymphocytes studied in vivo and in vitro

Neoplasma

Volumn 46, Issue SUPPL. 1, 1999, Pages 20-22

  Jaloszynski P ^a   Tadrowska M ^a   Kujawski, M ^a   Wasowicz M ^b   Szulc, R ^b   Szyfter, K ^a  

^a POLISH ACADEMY OF SCIENCES   (Poland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Comet assay; Genotoxicity in vitro and in vivo; Inhalation anesthetics; Sevoflurane

Indexed keywords

EID: 21944457031     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. BADEN, J.M., SIMMON, V.F.: Mutagenic effects of inhalational anesthetics. Mutat. Res., 75, 1980, 169-189.
2. COATE, W.B., ULLAND, B.M., LEWIS, T.R.: Chronic exposure to low concentrations of halothane-nitrous oxide: Reproductive and cytogenetic effect in the rat. Anesthesiology, 50, 1979, 310-318.
3. JAŁOSZYŃSKI, P., KUJAWSKI, M., WA̧SOWICZ, M., SZULC, R., SZYFTER, K.: Genotoxicity of inhalation anesthetics halothane and isoflurane in human lymphocytes studied in vitro using the comet assay. Mutat. Res., 439, 1999, 199-206.
4. KRAMER, P.G.N., BURM, A.G.L.: Mutagenicity studies with halothane in Drosophila melanogaster. Anesthesiology, 50, 1979, 510-513.
5. KUSYK, C.J., HSU, T.C.: Mitotic anomalies induced by three inhalation halogenated anesthetics. Environ. Res., 12, 1976, 366-370.
6. RUBEŠ, J., KUCHAROVÁ, S., VOZDOVÁ, M., MUSILOVÁ, P., ZUDOVÁ, Z.: Cytogenetic analysis of peripheral lymphocytes in medical personnel by means of FISH. Mutat. Res., 412, 1998, 293-298.
7. ŞARDAŞ, S., KARABIYIK, L., AYGÜN, N., KARAKAYA, A.E.: DNA damage evaluated by the alkaline comet assay in lymphocytes of humans anaesthetized with isoflurane. Mutat. Res., 418, 1998, 1-6.
8. ŞARDAŞ, S., AYGŪN, N., GAMLI, M., ÜNAL, Y., ÜNAL, N., BERK, N., KARAKAYA, A.E.: Use of alkaline comet assay (single cell gel electrophoresis technique) to detect DNA damages in lymphocytes of operating room personnel occupationally exposed to anaesthetic gases. Mutat. Res., 418, 1998, 93-100.
9. STURROCK, J.E., NUNN, J.F.: Synergism between halothane and nitrous oxide in the production of nuclear abnormalities in the dividing fibroblasts. Anesthesiology, 44, 1976, 461-471.