Modulation of protein kinases on an Alzheimer-like phosphorylation of τ

Progress in Biochemistry and Biophysics

Volumn 26, Issue 4, 1999, Pages 375-402

  Wang, Jian Zhi ^a   Wang, Qun ^a   Wu, Qiong Li ^a   Grundke Iqbal, I ^a   Iqbal, K ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

protein; Abnormal phosphorylation; Alzheimer disease; Protein kinase

Indexed keywords

EID: 21944438475     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Iqbal K, Alonso A, Gong C X, et al. τ Phosphatase. In: Kosik K, Avila J, eds. Brain microtubule associated proteins: modifications and diseases. New York: Harwood Academic Publishers, 1997. 95-111
2. Wang J Z, Gong C X, Zaidi T, et al. Dephosphorylation of Alzheimer paired heljcal filaments by PP-2A and PP-2B. J Biol Chem, 1995, 270 (9): 4854-4860
3. Wang J Z, Grundke-Iqbal I, Iqbal K. Glycosylation of microtubule associated protein tau: an abnormal posttranslational modification in Alzheimer dis
4. Singh T J, Grundke-Iqbal I, Wu Q L, et al. Protein kinase C and culcium/calmodulin-dependent protein kinase II phosphorylate three repeat and four-repeat tau isoforms at defferent rates. Mol Cell Biochem, 1997, 168 (1): 141-148
5. Goedert M, Jake R. Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J, 1990, 9 (2): 4225-4230
6. Singh T J, Wang J Z, Novak M, et al. Calcium/calmodulin-dependent protein kinase II phosphorylates tau at ser-262 but only partially inhibits its binding to microtubules. FEES Lett, 1996, 387 (1): 145-148