Inhibitory activity of isorhamnetin from Persicaria thunbergii on farnesyl protein transferase

Archives of Pharmacal Research

Volumn 28, Issue 2, 2005, Pages 169-171

  Hyun, Mi Oh ^b   Kwon, Byoung Mog ^b   Baek, Nam In ^c   Kim, Sung Hoon ^c   Chung, In Sik ^c   Park, Mi Hyun ^d   Hee, Wook Park ^a   Jae, Hyeok Lee ^a   Hye, Won Park ^a   Eun, Jeong Kim ^a   Dae, Keun Kim ^a  

^a Woosuk University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Kyung Hee University   (South Korea)

^d Erom Life Co Ltd   (South Korea)

Author keywords

FPTase; Isorhamnetin; Persicaria thunbergii

Indexed keywords

3-METHYLQUERCETIN; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; FLAVONOL DERIVATIVE; PLANT EXTRACT; QUERCETIN 3 METHYL ETHER; TRANSFERASE;

ANGIOSPERM; ARTICLE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THIN LAYER CHROMATOGRAPHY;

ALKYL AND ARYL TRANSFERASES; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; FLAVONOLS; MAGNETIC RESONANCE SPECTROSCOPY; PLANT EXTRACTS; POLYGONACEAE;

EID: 21844475210     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977709     Document Type: Article

References (12)

1. Agrawal, P. K., Carbon-13NMR of flavonoids, Elsvier, New York, p. 154 (1989).
2. Agullo, G., Gamet-Payrastre, L., Manenti, S., Viala, C., Remesy, C., Chap, H., and Payrastre, B., Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem. Pharmacol., 53, 1649-1657 (1997).
3. Di Carlo, G., Mascolo, N., lzzo, A. A., and Capasso, F., Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci., 65, 337-353 (1999).
4. Gibbs, J. B., Pompliano, D. L., Mosser, S. D., Rands, E., Lingham, R. B., Singh, S. B., Scolnick, E. M., Kohl, N. E., and Oliff, A., Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. J. Biol. Chem., 268, 7617-7620 (1993).
5. Kohl, N. E., Wilson, F. R., Mosser, S. D., Giulani, E. A., De Solms, S. J., Conner, M. W., Anthony, N. J., Holtz, W. J., Gomez, R. P., Lee, T. J., Smith, R. L., Hartman, G. D., Gibbs, J. B., and Oliff, A., Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc. Natl. Acad. Sci. U.S.A., 91, 9141-9145 (1994).
6. Kawabata, K., Tanaka, T., Honjo, S., Kakumoto, M., Hara, a., Makita, H., Tatematsu, N., Ushida, J., Tsuda, H., and Mori, H., Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis. Int. J. Cancer, 83, 381-386 (1999).
7. Kuo, P. C., Liu, H. F., and Chao, J. L., Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in the human lung carcinoma cells. J. Biol. Chem., In press.
8. Lee, S. H., Kim, H. K, Kang, H. M., Seo, J. M., Son, K. H., Lee, H. S., and Kwon, B. M., Arteminolides B, C., and D, new inhibitors of Farnesyl Protein Transferase from Artemisia argyi. J. Org. Chem., 67, 7670-7675 (2002).
9. Lee, S. H., Lee, M.Y., Kang, H. M., Han, D. C., Son, K. H., Yang, D. C., Sung, N. D., Lee, C. W., Kim, H. M., and Kwon, B. M., Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa. Bioorg. Med. Chem., 11, 4545-4549 (2003).
10. Qian, Y., Sebti, S. M., and Hamilton, A. D., Farnesyltransferase as a target for anticancer drug design. Biopoly., 43, 25-41 (1997).
11. Reiss, Y., Goldstein, J. L., Seabra, M. C., Casey, P. J., and Brown, M. S., Inhibition of purified p21 Ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell, 62, 81-88 (1990).
12. Yook, C. S., Medicinal plants of Korea. Jinmyeong publishing Co., Seoul., p. 95 (1981).