Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours

Journal of Clinical Pathology

Volumn 58, Issue 7, 2005, Pages 695-699

  Hubeek, I ^a   Peters, G J ^a   Broekhuizen, A J F ^a   Talianidis, I ^b   Sigmond, J ^a   Gibson, B E S ^c   Creutzig, U ^d   Giaccone, G ^a   Kaspers, G J L ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUTE OF COMPUTER SCIENCE   (Greece)

^c MRC Childhood Leukaemia Working Party   (United Kingdom)

^d AML BFM Study Group   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYCYTIDINE KINASE; DEOXYNUCLEOSIDE ANALOG; NUCLEOSIDE ANALOG; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; ARTICLE; BLAST CELL; BRAIN TUMOR; CANCER SCREENING; CELL STRAIN CCRF CEM; CELL STRAIN HL 60; CELL STRAIN U937; CELLULAR DISTRIBUTION; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; EVALUATION; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RELIABILITY; RETINOBLASTOMA; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SOLID TUMOR; TUMOR CELL LINE; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; BRAIN NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CHILD; CYTOPLASM; DEOXYCYTIDINE KINASE; HUMANS; IMMUNOENZYME TECHNIQUES; LEUKEMIA; LUNG NEOPLASMS; NEOPLASMS; RETINAL NEOPLASMS; RETINOBLASTOMA; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 21844462854     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2004.023861     Document Type: Article

References (30)

1. Bohman C, Eriksson S. Deoxycytidine kinase from human leukemic spleen: preparation and characteristics of homogeneous enzyme. Biochemistry 1988;27:4258-65.
2. Arner ES, Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol Ther 1995;67:155-86.
3. Eriksson S, Munch-Petersen B, Johansson K, et al. Structure and function of cellular deoxyribonucleoside kinases. Cell Mol Life Sci 2002;59:1327-46.
4. De Clercq E. Antiviral drugs: current state of the art. J Clin Virol 2001;22:73-89.
5. Peters GJ, Van der Wilt CL, Van Moorsel G, et al. Basis for effective combination cancer chemotherapy with antimetabolites. Pharmacol Ther 2000;87:227-53.
6. Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues and nucleobases in cancer treatment. Lancet Oncol 2002;3:415-24.
7. Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001;15:875-90.
8. Verhoef V, Sarup J, Fridland A. Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases. Cancer Res 1981;41:4478-83.
9. Bhalla K, Nayak R, Grant S. Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D-arabinofuranosylcytosine. Cancer Res 1984;44:5029-37.
10. Stegmann AP, Honders MW, Kester MG, et al. Role of deoxycytidine kinase in an in vitro model for AraC- and DAC-resistance: substrate-enzyme interactions with deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-aza-2′- deoxycytidine. Leukemia 1993;7:1005-11.
11. Ruiz van Haperen V, Veerman G, Eriksson S, et al. Development and molecular characterization of a 2′,2′-difluorodeoxycytidine- resistant variant of the human ovarian carcinoma cell line A2780. Cancer Res 1994;54:4138-43.
12. Hapke DM, Stegmann AP, Mitchell BS. Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity. Cancer Res 1996;56:2343-7.
13. Dumontet C, Fabianowska-Majewska K, Mantincic D, et al. Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562. Br J Haematol 1999;106:78-85.
14. Stegmann AP, Honders WH, Willemze R, et al. Transfection of wild-type deoxycytidine kinase (dck) cDNA into an AraC- and DAC-resistant rat leukemic cell line of clonal origin fully restores drug sensitivity. Blood 1995;85:1188-94.
15. Kroep JR, Loves WJ, Van der Wilt CL, et al. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 2002;1:371 -6.
16. Chottiner EG, Shewach DS, Datta NS, et al. Cloning and expression of human deoxycytidine kinase cDNA. Proc Natl Acad Sci U S A 1991;88:1531-5.
17. Song JJ, Walker S, Chen E, et al. Genomic structure and chromosomal localization of the human deoxycytidine kinase gene. Proc Natl Acad Sci U S A 1993;90:431-4.
18. Mitchell BS, Song JJ, Johnson EE, et al. Regulation of human deoxycytidine kinase expression. Adv Enzyme Regul 1993;33:61-8.
19. Johansson M, Brismar S, Karlsson A. Human deoxycytidine kinase is located in the cell nucleus. Proc Natl Acad Sci USA 1997;94:11941-5.
20. Johansson M, Karlsson A. Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2. J Biol Chem 1997;272:8454-8.
21. Karlsson A, Johansson M, Eriksson S. 2 cloning and expression of mouse deoxycytidine kinase. Pure recombinant mouse and human enzymes show differences in substrate specificity. J Biol Chem 1994;269:24374-8.
22. Chen EH, Johnson EE, Vetter SM, et al. Characterization of the deoxycytidine kinase promoter in human lymphoblast cell lines. J Clin Invest 1995;95:1660-8.
23. Spasokoukotskaja T, Arner ES, Brosjo O, et al. Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues. Eur J Cancer 1995;31A:202-8.
24. Hatzis P, Al Madhoon AS, Jullig M, et al. The intracellular localization of deoxycytidine kinase. J Biol Chem 1998;273:30239-43.
25. Schouten-van Meeteren AY, Van der Valk P, Van der Linden HC, et al. Histopathologic features of retinoblastoma and its relation with in vitro drug resistance measured by means of the MTT assay. Cancer 2001;92:2933-40.
26. Schouten van Meeteren AY, Van der Valk P, Van der Linden HC, et al. Features of proliferation and in vitro drug resistance in central primitive neuro-ectodermal tumours. Neuropathol Appl Neurobiol 2002;28:200-9.
27. Van der Wilt CL, Kroep JR, Loves WJ, et al. Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver. Eur J Cancer 2003;39:691-7.
28. Kaspers GJ, Zwaan CM, Pieters R, et al. Cellular drug resistance in childhood acute myeloid leukemia. A mini-review with emphasis on cell culture assays. Adv Exp Med Biol 1999;457:415-21.
29. Landis JR, Koch GG. An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics 1977;33:363-74.
30. Inomata M, Kaneko A. Chemosensitivity profiles of primary and cultured human retinoblastoma cells in a human tumor clonogenic assay. Jpn J Cancer Res 1987;78:858-68.