Inhibition of calmodulin-dependent protein kinase II by cyclic and linear peptide alkaloids from Zizyphus species

Archives of Pharmacal Research

Volumn 28, Issue 2, 2005, Pages 159-163

  Yong, Nam Han ^a   Keum, Hee Hwang ^b   Byung, Hoon Han ^a  

^a Seoul National University   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

Calmodulin; Calmodulin dependent protein kinase II; Peptide alkaloid; Rhamnaceae; Zizyphus alkaloids

Indexed keywords

ALKALOID; CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN-DEPENDENT PROTEIN KINASE II; PEPTIDE; PROTEIN KINASE (CALCIUM,CALMODULIN); TRYPTOPHAN HYDROXYLASE;

ANIMAL; ARTICLE; BRAIN STEM; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; JUJUBE; METABOLISM; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; BRAIN STEM; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN HYDROXYLASE; ZIZIPHUS;

EID: 21844442651     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977707     Document Type: Article

References (24)

1. Fujisawa, H., Yamauchi, T. Nakata, H.,and Okuno, S., Role of calmodulin in neurotransmitter synthesis. In Cheung, W.Y. (ed.). Calcium and Cell Function. Academic press, New York, Vol. V, pp67-99 (1984).
2. Friedman, P. A., Kappelman, A. H., and Kaufman, S., Partial purification and characterization of tryptopahn hydroxylase from rabbit bind brain. J. Biol. Chem., 247, 4165-4173 (1972).
3. 2+-transport ATPase by phenothiazines and butyrophenones. Biochim. Biophys. Res. Commun., 94, 674-681 (1980)
4. Han, B. H. and Park, M. H., Alkaloids are the sedative principles of the seeds of Zizyphus vulgaris var. spinosus. Arch. Pharm. Res., 10, 203-207 (1987a).
5. Han, B. H. and Park, M. H., Sedative activity and its active components of Zizyphi fructucs. Arch. Pharm. Res., 10, 208-211 (1987b).
6. Han, B. H., Park, J. H., Park, M. H., Han,Y. N., and Park, M. K., Absolute configuration of sanjoinine A (frangufoline) and its heat induced artifact: sanjoinine-Ah1. Arch. Pharm. Res., 10, 200-201 (1987c).
7. Han, B. H., Park, M. H., and Han, Y. N., Cyclic peptide and peptide alkaloids from seeds of Zizyphus vulgaris. Phytochemistry, 29, 3315-3319 (1990).
8. Han, B. H., Park, M. H., and Han, Y. N., Sedative activity of aporphin and cyclopeptide alkaloids isoloated from the seeds of Zizyphus vulgaris var.spinosus, and the fruits and stem bark of Zizyphus jujuba var. inermis in mice.Yakhak Hoeji, 37, 143-148 (1993a).
9. Han, B. H., Park, M. H., and Han, Y. N., Studies on the sedative alkaloids from Zizyphus spinosus semen. Kor. J. Pharmacogn., 16, 233-238 (1985).
10. Han, B. H., Park, M. H., and Park, J. H., Chemical and pharmacological studies on sedative cyclopeptide alkaloids in some Rhamnaceae plants. Pure Appl.Chem., 61, 443-448 (1989).
11. Han, Y. N., Kim, G. -Y., Hwang, K. H., and Han, B. H., Binding of sanjoinine-A (frangufoline) to calmodulin. Arch. Pharm. Res., 16, 289-294 (1993b).
12. Kanno, K. and Sasaki, Y., Interaction of psychotropic drugs with phospholipids. Biochem. Pharmacol., 31, 2977-2981 (1982).
13. Klee, C.B., Crouch, T. H., and Richman, P. G., Calmodulin. Annu. Rev. Biochem.,49, 489-515 (1980).
14. Hwang, K. H., Han, Y. N., and Han, B. H., Inhibition of calmodulin-dependent calcium ATPase and phosphodi-esterase by various cyclopeptides and peptide alkaloids from the Zizyphus species. Arch. Pharm. Res., 24, 202-206 (2001).
15. 2+: dependence on calmodulin. Pro.Natl. Acad. Sci. U.S.A., 77, 4688-4691 (1980).
16. Levin, R. M. and Weiss, B., Mechanism by which psychotropic drugs inhibit adenosine cyclic 3,5-monophosphate phosphodiesterase of brain. Mol. Pharmacol., 12, 581-589 (1976).
17. Levin, R. M. and Weiss, B., selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase. J. Pharmacol. Exp. Ther., 208, 454-459 (1979).
18. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951).
19. Nakada, H. and Fujisawa, H., Purification and properties of tryptophan 5-momooxygenase from rabbit brainstem. Eur. J. Biochem., 122, 41-47 (1982).
20. Norman, J. A., Drummond, A. H., and Moser, P., Inhibition of calcium-dependent regulator-stimulated phosphodiesterase activity by neuroleptic drugs is unrelated to their clinical efficacy. Mol. Pharmacol., 16, 1089-1094 (1979).
21. Park, M. K., Park, J. H., Cho, J. H., Park, J. K., Han, Y. N. and Han, B. H., Ionophore activity of fragufoline. Arch. Pharm. Res.,14, 103-104 (1991).
22. Suh, D.-Y., Kim, Y. C., Han, Y. N., and Han, B. H., Unusual enamide cleavage of frangulfoline under mild acidic condition. Heterocycles, 43, 2347-2361 (1996).
23. Tschesche, R. and Kaussmann, E. U., The cyclopeptide alkaloids. The alkaloids. Academic Press, New York, vol. 15, pp165-205 (1975).
24. Yamauchi, T. and Fujisawa, H., Purification and characterization of the brain calmodulin-dependent protein kinase (kinase II), which is involved in the activation of tryptophan 5-monooxygenase. Eur.J.Biochem., 132, 15-21 (1983).