The somatomedin hypothesis revisited in a transgenic model

Growth Hormone and IGF Research

Volumn 11, Issue SUPPL. 1, 2001, Pages

  Isaksson, Olle ^a   Ohlsson, Claes ^a   Sjögren, Klara ^a   Wallenius, Kristina ^a   Jansson, John Olov ^a,b  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Body growth; Growth hormone; Insulin like growth factor I; Knockout; Liver; Mice

Indexed keywords

CRE RECOMBINASE; INTEGRASE; SOMATOMEDIN; SOMATOMEDIN C; VIRUS PROTEIN;

ANIMAL; BODY WEIGHT; GENETIC ENGINEERING; GENETICS; HUMAN; LIVER; METABOLISM; METHODOLOGY; MOUSE; MOUSE MUTANT; ORGAN SIZE; PHYSIOLOGY; REVIEW; TRANSGENIC MOUSE;

ANIMALS; BODY WEIGHT; GENETIC ENGINEERING; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTEGRASES; LIVER; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN SIZE; SOMATOMEDINS; VIRAL PROTEINS;

EID: 21844437095     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-6374(01)80008-3     Document Type: Review

References (4)

1. Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993; 75: 73-82.
2. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-1) and type 1 IGF receptor (Igf1r). Cell 1993; 75: 59-72.
3. Powell-Braxton L, Hollingshead P, Giltinan D, Pitts-Meek S, Stewart T. Inactivation of the IGF-I gene in mice results in perinatal lethality. Ann N Y Acad Sci 1993; 692: 300-301.
4. Liu JL, Grinberg A, Westphal H, et al. Insulin-like growth factor-1 affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol Endocrinol 1998; 12: 1452-1462.