Bronchial hyperresponsiveness, airway inflammation, and airflow limitation in endurance athletes

Chest

Volumn 127, Issue 6, 2005, Pages 1935-1941

  Vergès, Samuel ^a   Devouassoux, Gilles ^b   Flore, Patrice ^a   Rossini, Eliane ^a   Fior Gozlan, Michèle ^b   Levy, Patrick ^a,b   Wuyam, Bernard ^a,b,c  

^a University Grenoble Alpes   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

^c HÔPITAL MICHALLON   (France)

Author keywords

Airflow limitation; Airway inflammation; Athlete; Bronchial; Eosinophil; Exercise; Hyperresponsiveness; Nitric oxide

Indexed keywords

CORTICOSTEROID; METHACHOLINE; NITRIC OXIDE; DIAGNOSTIC AGENT; METHACHOLINE CHLORIDE;

ARTICLE; ATHLETE; ATOPY; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; ENDURANCE; EOSINOPHILIA; EXERCISE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN EXPERIMENT; HYPERVENTILATION; INFLAMMATION; LUNG CLEARANCE; MALE; PRIORITY JOURNAL; SPIROMETRY; SPUTUM ANALYSIS; ADULT; AIRWAY OBSTRUCTION; BRONCHITIS; BRONCHOSPASM; CROSS-SECTIONAL STUDY; INCIDENCE; INHALATION TEST; LUNG FUNCTION TEST; NONPARAMETRIC TEST; PHYSIOLOGY; PROBABILITY; REFERENCE VALUE; RISK ASSESSMENT; SPORT;

ADULT; AIRWAY OBSTRUCTION; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHITIS; BRONCHOCONSTRICTION; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INCIDENCE; MALE; METHACHOLINE CHLORIDE; PHYSICAL ENDURANCE; PROBABILITY; REFERENCE VALUES; RESPIRATORY FUNCTION TESTS; RISK ASSESSMENT; SPIROMETRY; SPORTS; STATISTICS, NONPARAMETRIC;

EID: 21844432954     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.127.6.1935     Document Type: Article

References (37)

1. Langdeau JB, Turcotte H, Bowie DM, et al. Airway hyperresponsiveness in elite athletes. Am J Respir Crit Care Med 2000; 161:1479-1484
2. Nystad W, Harris J, Borgen JS. Asthma and wheezing among Norwegian elite athletes. Med Sci Sports Exerc 2000; 32: 266-270
3. Wilber RL, Rundell KW, Szmedra L, et al. Incidence of exercise-induced bronchospasm in Olympic winter sport athletes. Med Sci Sports Exerc 2000; 32:732-737
4. Karjalainen EM, Laitinen A, Sue-Chu M, et al. Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine. Am J Respir Crit Care Med 2000; 161:2086-2091
5. Helenius IJ, Rytila P, Metso T, et al. Respiratory symptoms, bronchial responsiveness, and cellular characteristics of induced sputum in elite swimmers. Allergy 1998; 53:346-352
6. Bonsignore MR, Morici G, Riccobono L, et al. Airway inflammation in nonasthmatic amateur runners. Am J Physiol Lung Cell Mol Physiol 2001; 281:L668-L776
7. Lumme A, Haahtela T, Ounap J, et al. Airway inflammation, bronchial hyperresponsiveness and asthma in elite ice hockey players. Eur Respir J 2003; 22:113-117
8. Sue-Chu M, Larsson L, Moen T, et al. Bronchoscopy and bronchoalveolar lavage findings in cross-country skiers with and without "ski asthma." Eur Respir J 1999; 13:626-632
9. Sue-Chu M, Henriksen AH, Bjermer L. Non-invasive evaluation of lower airway inflammation in hyper-responsive elite cross-country skiers and asthmatics. Respir Med 1999; 93: 719-725
10. Sue-Chu M, Karjalainen EM, Altraja A, et al. Lymphoid aggregates in endobronchial biopsies from young elite cross-country skiers. Am J Respir Crit Care Med 1998; 158:597-601
11. Davis MS, Freed AN. Repeated hyperventilation causes peripheral airways inflammation, hyperreactivity, and impaired bronchodilation in dogs. Am J Respir Crit Care Med 2001; 164:785-789
12. Anderson SD, Holzer K. Exercise-induced asthma: is it the right diagnosis in elite athletes? J Allergy Clin Immunol 2000; 106:419-428
13. Bonsignore MR, Morici G, Vignola AM, et al. Increased airway inflammatory cells in endurance athletes: what do they mean? Clin Exp Allergy 2003; 33:14-21
14. Gelb AF, Tashkin DP, Epstein JD, et al. Exercise-induced bronchodilation in asthma. Chest 1985; 87:196-201
15. Johnson BD, Scanlon PD, Beck KC. Regulation of ventilatory capacity during exercise in asthmatics. J Appl Physiol 1995; 79:892-901
16. Beck KC, Offord KP, Scanlon PD. Bronchoconstriction occurring during exercise in asthmatic subjects. Am J Respir Crit Care Med 1994; 149:352-357
17. Suman OE, Babcock MA, Pegelow DF, et al. Airway obstruction during exercise in asthma. Am J Respir Crit Care Med 1995; 152:24-31
18. Rundell KW, Spiering BA, Judelson DA, et al. Bronchoconstriction during cross-country skiing: is there really a refractory period? Med Sci Sports Exerc 2003; 35:18-26
19. Johnson BD, Saupe KW, Dempsey JA. Mechanical constraints on exercise hyperpnea in endurance athletes. J Appl Physiol 1992; 73:874-886
20. Rundell KW, Im J, Mayers LB, et al. Self-reported symptoms and exercise-induced asthma in the elite athlete. Med Sci Sports Exerc 2001; 33:208-213
21. Burney PG, Luczynska C, Chinn S, et al. The European Community Respiratory Health Survey. Eur Respir J 1994; 7:954-960
22. Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations; the European Respiratory Society Task Force. Eur Respir J 1997; 10:1683-1693
23. Sterk PJ, Fabbri LM, Quanjer PH, et al. Airway responsiveness: standardized challenge testing with pharmacologic, physical and sensitizing stimuli in adults; Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993; 16:53-83
24. Kauffmann F, Dizier MH, Annesi-Maesano I, et al. EGEA (Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness and Atopy): descriptive characteristics. Clin Exp Allergy 1999; 29:17-21
25. Woolley M, Anderson SD, Quigley BM. Duration of protective effect of terbutaline sulfate and cromolyn sodium alone and in combination on exercise-induced asthma. Chest 1990; 97:39-45
26. Paggiaro PL, Chanez P, HoIz O, et al. Sputum induction. Eur Respir J Suppl 2002; 37:3s-8s
27. Johnson BD, Weisman IM, Zeballos RJ, et al. Emerging concepts in the evaluation of ventilator)' limitation during exercise: the exercise tidal flow-volume loop. Chest 1999; 116:488-503
28. Leuppi JD, Kühn M, Comminot C, et al. High prevalence of bronchial hyperresponsiveness and asthma in ice hockey players. Eur Respir J 1998; 12:13-16
29. Holzer K, Anderson SD, Douglass J. Exercise in elite summer athletes: challenges for diagnosis. J Allergy Clin Immunol 2002; 110:374-380
30. Henriksen AH, Tveit KH, Holmen TL, et al. A study of the association between exercise-induced wheeze and exercise versus methacholine-induced bronchoconstriction in adoles-cents. Pediatr Allergy Immunol 2002; 13:203-208
31. Joos GF, O'Connor B, Anderson SD, et al. Indirect airway challenges. Eur Respir J 2003; 21:1050-1068
32. Pin I, Radford S, Kolendowicz R, et al. Airway inflammation in symptomatic and asymptomatic children with methacho-line hyperresponsiveness. Eur Respir J 1993; 6:1249-1256
33. Metso T, Rytila P, Peterson C, et al. Granulocyte markers in induced sputum in patients with respirator)' disorders and healthy persons obtained by two sputum-processing methods. Respir Med 2001; 95:48-55
34. Bousquet J, Jeffery PK, Busse WW, et al. Asthma: from bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000; 161:1720-1745
35. Beck KC. Control of airway function during and after exercise in asthmatics. Med Sei Sports Exerc 1999; 31:S4-SIl
36. Schaefer O, Eaton RD, Timmermans FJ, et al. Respirator)' function impairment and cardiopulmonary consequences in long-time residents of the Canadian Arctic. Can Med Assoc J 1980; 123:997-1004
37. Verges S, Flore P, Rousseau Blanchi MP, et al. A 10-year follow-up study of pulmonary function in symptomatic elite cross-country skiers. Scand J Med Sei Sports 2004; 14:381-387