A novel anti-platelet monoclonal antibody (3C7) specific for the complex of integrin αIIbβ3 inhibits platelet aggregation and adhesion

Journal of Biological Chemistry

Volumn 280, Issue 27, 2005, Pages 25403-25408

  Chen, Ping ^a   Sun, Chong Xiu ^a   Liu, Jian Ning ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; AGGLOMERATION; CHELATION; COLLAGEN; CYTOLOGY; MONOCLONAL ANTIBODIES;

CYTOMETRY; FIBRINOGENS; PEPTIDES; PLATELETS;

CELLS;

ADENOSINE DIPHOSPHATE; ANTIGEN; ARGINYLGLYCYLASPARTYLSERINE; CYSTEINE; EPITOPE; INTEGRIN; INTEGRIN ALPHAIIBBETA3; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3C7; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CHO CELL; CONFORMATIONAL TRANSITION; DOSE RESPONSE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION;

ADENOSINE DIPHOSPHATE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BLOOD PLATELETS; CHO CELLS; CRICETINAE; EPITOPES; FIBRINOGEN; HEMOSTATICS; MICE; MICE, INBRED BALB C; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THROMBIN;

CRICETULUS GRISEUS;

EID: 21844431869     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500462200     Document Type: Article

References (46)

1. Fitzgerald, D. J., Roy, L., Catella, F., and FitzGerald, G. A. (1986) N. Engl. J. Med. 315, 983-989
2. Bennett, J. S., and Vilaire, G. (1979) J. Clin. Investig. 64, 1393-1401
3. Davies, M. J., and Thomas, A. C. (1985) Br. Heart J. 53, 363-373
4. Frelinger, A. L., III, Cohen, I., Plow, E. F., Smith, M. A., Roberts, J., Lam, S. C., and Ginsberg, M. H. (1990) J. Biol. Chem. 265, 6346-6352
5. Kouns, W. C., Wall, C. D., White, M. M., Fox, C. F., and Jennings, L. K. (1990) J. Biol. Chem. 265, 20594-20601
6. Braunwald, E., Maseri, A., Armstrong, P. W., Califf, R. M., Gibler, W. B., Hamm, C. W., Simoons, M. L., and Van de, W. F. (1998) Eur. Heart J. 19, Suppl. D, 22-30
7. Fuster, V. (1994) Circulation 90, 2126-2146
8. Hirsh, P. D., Hillis, L. D., Campbell, W. B., Firth, B. G., and Willerson, J. T. (1981) N. Engl. J. Med. 304, 685-691
9. Willerson, J. T., Golino, P., Eidt, J., Campbell, W. B., and Buja, L. M. (1989) Circulation 80, 198-205
10. Lefkovits, J., Plow, E. F., and Topol, E. J. (1995) N. Engl. J. Med. 332, 1553-1559
11. Tam, S. H., Sassoli, P. M., Jordan, R. E., and Nakada, M. T. (1998) Circulation 98, 1085-1091
12. Lefkovits, J., and Topol, E. J. (1996) Eur. Heart J. 17, 9-18
13. Scarborough, R. M., Kleiman, N. S., and Phillips, D. R. (1999) Circulation 100, 437-444
14. Topol, E. J., Byzova, T. V., and Plow, E. F. (1999) Lancet 353, 227-231
15. Jennings, L. K., Phillips, D. R., and Walker, W. S. (1985) Blood 65, 1112-1119
16. Ruiz, C., Liu, C. Y., Sun, Q. H., Sigaud-Fiks, M., Fressinaud, E., Muller, J. Y., Nurden, P., Nurden, A. T., Newman, P. J., and Valentin, N. (2001) Blood 98, 2432-2441
17. Pasquet, J. M., Dachary-Prigent, J., and Nurden, A. T. (1996) Eur. J. Biochem. 239, 647-654
18. Shadle, P. J., and Barondes, S. H. (1982) J. Cell Biol. 95, 361-365
19. Hughes, P. E., O'Toole, T. E., Ylanne, J., Shattil, S. J., and Ginsberg, M. H. (1995) J. Biol. Chem. 270, 12411-12417
20. Duperray, A., Troesch, A., Berthier, R., Chagnon, E., Frachet, P., Uzan, G., and Marguerie, G. (1989) Blood 74, 1603-1611
21. Shattil, S. J., Brass, L. F., Bennett, J. S., and Pandhi, P. (1985) Blood 66, 92-98
22. Frelinger, A. L., III, Du, X. P., Plow, E. F., and Ginsberg, M. H. (1991) J. Biol. Chem. 266, 17106-17111
23. Mazurov, A. V., Khaspekova, S. G., Byzova, T. V., Tikhomirov, O. Y., Berndt, M. C., Steiner, B., and Kouns, W. C. (1996) FEBS Lett. 391, 84-88
24. Puzon-McLaughlin, W., Kamata, T., and Takada, Y. (2000) J. Biol. Chem. 275, 7795-7802
25. Ginsberg, M. H., Lightsey, A., Kunicki, T. J., Kaufmann, A., Marguerie, G., and Plow, E. F. (1986) J. Clin. Investig. 78, 1103-1111
26. Shadle, P. J., Ginsberg, M. H., Plow, E. F., and Barondes, S. H. (1984) J. Cell Biol. 99, 2056-2060
27. Shattil, S. J., Hoxie, J. A., Cunningham, M., and Brass, L. F. (1985) J. Biol. Chem. 260, 11107-11114
28. Loftus, J. C., Plow, E. F., Frelinger, A. L., III, D'Souza, S. E., Dixon, D., Lacy, J., Sorge, J., and Ginsberg, M. H. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 7114-7118
29. Andrieux, A., Rabiet, M. J., Chapel, A., Concord, E., and Marguerie, G. (1991) J. Biol. Chem. 266, 14202-14207
30. Jacobin, M. J., Laroche-Traineau, J., Little, M., Keller, A., Peter, K., Welschof, M., Nurden, A., and Clofent-Sanchez, G. (2002) J. Immunol. 168, 2035-2045
31. Xiong, J. P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D. L., Joachimiak, A., Goodman, S. L., and Arnaout, M. A. (2001) Science 294, 339-345
32. Kamata, T., Tieu, K. K., Tarui, T., Puzon-McLaughlin, W., Hogg, N., and Takada, Y. (2002) J. Immunol. 168, 2296-2301
33. Evans, R. D., Perkins, V. C., Henry, A., Stephens, P. E., Robinson, M. K., and Watt, F. M. (2003) J. Cell Biol. 160, 589-596
34. Miao, H., Li, S., Hu, Y. L., Yuan, S., Zhao, Y., Chen, B. P., Puzon-McLaughlin, W., Tarui, T., Shyy, J. Y., Takada, Y., Usami, S., and Chien, S. (2002) J. Cell Sci. 115, 2199-2206
35. Chen, P., Melchior, C., Brons, N. H., Schlegel, N., Caen, J., and Kieffer, N. (2001) J. Biol. Chem. 276, 38628-38635
36. Dorsam, R. T., and Kunapuli, S. P. (2004) J. Clin. Investig. 113, 340-345
37. Brass, L. F. (2003) Chest 124, 18S-25S
38. Calzada, M. J., Alvarez, M. V., and Gonzalez-Rodriguez, J. (2002) J. Biol. Chem. 277, 39899-39908
39. Hynes, R. O. (1992) Cell 69, 11-25
40. Tomiyama, Y., Tsubakio, T., Piotrowicz, R. S., Kurata, Y., Loftus, J. C., and Kunicki, T. J. (1992) Blood 79, 2303-2312
41. Niiya, K., Hodson, E., Bader, R., Byers-Ward, V., Koziol, J. A., Plow, E. F., and Ruggeri, Z. M. (1987) Blood 70, 475-483
42. Prammer, K. V., Boyer, J., Ugen, K., Shattil, S. J., and Kieber-Emmons, T. (1994) Receptor 4, 93-108
43. Peter, K., Schwarz, M., Ylanne, J., Kohler, B., Moser, M., Nordt, T., Salbach, P., Kubler, W., and Bode, C. (1998) Blood 92, 3240-3249
44. Blankenship, J. C. (1999) Am. Heart J. 138, 287-296
45. Joseph, J. E., and Machin, S. J. (1997) Blood Rev. 11, 178-190
46. Bednar, R. A., Gaul, S. L., Hamill, T. G., Egbertson, M. S., Shafer, J. A., Hartman, G. D., Gould, R. J., and Bednar, B. (1998) J. Pharmacol. Exp. Ther. 285, 1317-1326