Role of viral infections in the pathogenesis of type 1 diabetes;Le rôle des virus dans la pathogénie du diabète de type 1

Revue Medicale de Liege

Volumn 60, Issue 5-6, 2005, Pages 297-302

  Brilot, F ^a   Geenen, V ^b,c,d  

^a FNRS   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d CHU SART TILMAN   (Belgium)

Author keywords

Coxsackievirus B4; Thymus; Type 1 diabetes; Virus

Indexed keywords

AUTOANTIGEN; INSULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANTIGEN SPECIFICITY; CELL ACTIVITY; CELL CULTURE; COXSACKIE VIRUS B4; CYTOTOXIC T LYMPHOCYTE; EPITHELIUM CELL; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MOLECULAR MIMICRY; PANCREAS ISLET BETA CELL; REVIEW; THYMUS DISEASE; UPREGULATION; VIRUS INFECTION;

AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS B, HUMAN; ENTEROVIRUS INFECTIONS; HUMANS; MOLECULAR MIMICRY; T-LYMPHOCYTES; THYMUS GLAND;

EID: 21744439462     PISSN: 00353663     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (47)

1. Bennett ST, Todd JA.- Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annu Rev Genet, 1996, 30, 343-370.
2. Lo SS, Tun RY, Hawa M, et al.- Studies of diabetic twins. Diabetes Metab Rev, 1991, 7, 223-238.
3. Green A, Patterson CC.- Trends in the incidence of childhood-onset diabetes in Europe 1989-98. Diabetologia, 2001, 44, B3-8.
4. Zinkernagel RM.- Maternal antibodies, childhood infections, and autoimmune diseases. N Engl J Med, 2001, 345, 1331-1335.
5. Bach JF.- The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med, 2002, 347, 911-920.
6. Karvonen M, Viik-Kajander M, Moltchanova E, et al.- Incidence of childhood type 1 diabetes worldwilde. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care, 2000, 23, 1516-1526.
7. Bodansky HJ, Staines A, Stephenson C, et al.- Evidence for an environmental effect in the aetiology of insulin-dependent diabetes in a transmigratory population. Br Med J, 1992, 304, 1020-1022.
8. Serrano-Rios M, Qoday A, Martinez LT.- Migrant populations and the incidence of type 1 diabetes mellitus: an overview of the literature with a focus on the Spanish-heritage countries in Latin America. Diabetes Metab Rev, 1999, 15, 113-132.
9. Jun HS, Yoon JW.- The role of viruses in Type 1 diabetes: two distinct cellular and molecular mechanisms of virus-induced diabetes in animals. Diabetologia, 2001, 44, 271-285.
10. Jaeckel E, Manns M, Von Herrath M.- Viruses and diabetes. Ann NY Acad Sci, 2002, 958, 7-25.
11. Hyöti H, Hiltunen M, Knip M, et al.- A prospective study of the role of coxsackie B and enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes, 1995, 44, 652-667.
12. Yoon JW, Austin M, Onodera T, et al.- Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med, 1979, 300, 1173-1179.
13. Gamble DR, Kinsley ML, Fitzgerald MG, et al.- Viral antibodies in diabetes mellitus. Br Med J, 1969, 3, 627-630.
14. Gamble DR, Taylor KW.- Coxsackie B virus and diabetes. Br Med J, 1973, 1, 289-290.
15. Yoon JW, Kominek H.- Role of Coxsackie B viruses in the pathogenesis of diabetes mellitus. In: Friedman H, ed. Microorganisms and Autoimmune Diseases. Plenum Press, New York 1996; 129-158.
16. Clements GB, Galbraith DN, Taylor KW.- Coxsackie B virus infection and onset of childhood diabetes. Lancet, 1995, 346, 221-223.
17. Andreoletti L, Hober D, Hober-Vandenberghe C et al.- Detection of coxsackie B virus RNA sequences in whole blood samples from adult patients at the onset of type 1 diabetes mellitus. J Med Virol, 1997, 52, 121-127.
18. Chehadeh W, Kerr-Conte J, Pattou F et al.- Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha-interferon synthesis in beta cells. J Virol, 2000, 74, 10153-10164.
19. Yin H, Berg AK, Westman J, et al.- Complete nucleotide sequence of a Coxsackievirus B4 strain capable of establishing persistent infection in human pancreatic islet cells: Effects on insulin release, proinsulin synthesis, and cell morphology. J Med Virol, 2002, 68, 544-547.
20. Yin H, Berg AK, Tuvemo T, et al.- Enterovirus RNA is found in peripheral blood mononuclear cells in a majority of type 1 diabetic children at onset. Diabetes, 2002, 51, 1964-1971.
21. Atkinson MA, Bowman MA, Campbell L, et al.- Cellular immunity to a determinant common to glutamate decarboxylase and coxsackievirus in insulin-dependent diabetes. J Clin Invest, 1994, 94, 2125-2129.
22. Horwitz MS, Bradley LM, Harbetson J, et al.- Diabetes induced by coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med, 1998, 4, 781-785.
23. Richter W, Mertens T, Schoel B, et al.- Sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with Coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies. J Exp Med, 1994, 180, 721-726.
24. Christen U, Edelmann KH, McGavern DB, et al.- A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. J Clin Invest, 2004, 114, 1290-1298.
25. Horwitz MS, Sarvetnick N.- Viruses, host responses, and autoimmunity. Immunol Rev, 1999, 169, 241-253.
26. Flodström M, Maday A, Balakrishna D, et al.- Target cell defense prevents the development of diabetes after viral infection. Nat Immunol, 2002, 3, 373-384.
27. Green J, Casabonne D, Newton R.- Coxsackie B virus serology and type 1 diabetes mellitus: a systematic review of published case-control studies. Diab Med, 2004, 21, 507-514.
28. Foulis AK, McGill M, Farquharson MA, et al.- A search for evidence of viral infection in pancreases of newly diagnosed patients with IDDM. Diabetologia, 1997, 40, 53-61.
29. Buesa-Gomez J, de la Torre JC, Dyrberg T, et al.- Failure to detect genomic viral sequences in pancreatic tissue from two children with acute-onset diabetes mellitus. J Med Virol, 1994, 42, 193-197.
30. Gale EAM.- The rise of childhood type 1 diabetes in the twentieth century. Diabetes, 2002, 51, 3353-3361.
31. Chehadeh W, Weill J, Vantyghem MC, et al.- Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus: relationship with coxsackievirus B infection. J Infect Dis, 2000, 181, 1929-1939.
32. Robert F, Martens H, Cormann N, et al.- The recognition of hypothalamo-neurohypophysial functions by developing T cells. Dev Immunol, 1992, 2, 131-140.
33. Geenen V, Robert F, Martens H, et al.- The thymic education of developing T cells in self neuroendocrine principles. J Endocrinol Invest, 1992, 15, 621-629.
34. Martens H, Goxe B, Geenen V.- The thymic repertoire of neuroendocrine self-antigens: physiological implications in T-cell life and death. Immunol Today, 1996, 17, 312-317.
35. Like AA, Kislaukis E, Williams RM, et al.- Neonatal thymectomy prevents spontaneous diabetes in the BB:W rat. Science, 1982, 216, 644-646.
36. Georgiou HM, Bellgrau D.- Induction of insulitis in athymic (nude) mice. The effect of NOD thymus and pancreas transplantation. Diabetes, 1995, 44, 49-59.
37. Thomas-Vaslin V, Damotte D, Coltey M, et al.- Abnormal T-cell selection on NOD thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice. Proc Natl Acad Sci USA, 1997, 94, 4598-4603.
38. Kecha-Kamoun O, Achour I, Martens H, et al.- Thymic expression of insulin-related genes in an animal model of type 1 diabetes. Diabetes Metab Res Rev, 2001, 17, 146-152.
39. Brilot F, Chehadeh W, Charlet-Renard C, et al.- Persistent infection of human thymic epithelial cells by coxsackievirus B4. J Virol, 2002, 76, 5260-5265.
40. Brilot F, Geenen V, Hober D, Stoddart C.- Coxsackievirus B4 infection of human fetal thymus cells. J Virol, 2004, 78, 9854-9861.
41. Chatterjee NK, Hou J, Dockstader P, et al.- Coxsackievirus B4 infection alters thymic, splenic, and peripheral lymphocyte repertoire preceding onset of hyperglycemia in mice. J Med Virol, 1992, 38, 124-131.
42. Shih FF, Mandik-Nayak L, Wipke BT, et al.- Massive thymic deletion results in systemic autoimmunity through elimination of CD4+CD25+ T regulatory cells. J Exp Med, 2004, 199, 323-335.
43. Gale EAM, Atkinson M.- A piece of nucleic acid surrounded by controversy: coxsackievirus and the causes of Type 1 diabetes. Diab Med, 2004, 21, 503-506.
44. Roivainen M, Rasilainen S, Ylipaasto P, et al.- Mechanisms of coxsackievirus-induced damage to human pancreatic β-cells. J Clin Endocr Metab, 2000, 85, 432-40.
45. Horwitz MS, Ilic A, Fine C, et al.- Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes. J Clin Invest, 2002, 109, 79-87.
46. Lesage S, Hartley SB, Akkaraju S, et al.- Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J Exp Med, 2002, 196, 1175-1188.
47. Geenen V, Brilot F, Louis C, et al.- Nouvelles données sur la pathogénie du diabète de type 1. Rev Med Liège, 2005, 60, 291-296.