Forphenicinol enhances the antitumor effects of cyclophosphamide in a model of squamous cell carcinoma

Cancer Chemotherapy and Pharmacology

Volumn 56, Issue 3, 2005, Pages 317-321

  Murphy, Kevin T ^a   Wardak, Abdullah ^a   Beckett, Michael A ^a   Lopez, Carlos A ^a   Mehta, Neil ^a   Kimchi, Eric ^a   Salloum, Rabih M ^a   Jaskowiak, Nora T ^a   Posner, Mitchell C ^a   Ohno, Tsuneya ^c   Kufe, Donald W ^b   Weichselbaum, Ralph R ^a   Mauceri, Helena J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cyclophosphamide; Forphenicinol; Ionizing radiation; Tumor growth

Indexed keywords

CYCLOPHOSPHAMIDE; FORPHENICINOL;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENTIATION; FEMALE; HINDLIMB; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; SQUAMOUS CELL CARCINOMA; TUMOR VOLUME;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; DRUG SYNERGISM; FEMALE; GLYCINE; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED C3H; NEOPLASM TRANSPLANTATION; RADIOTHERAPY; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 21744435740     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0986-8     Document Type: Article

References (17)

1. Morishima H, Yoshizawa J, Ushijima R, Takeuchi T, Umezawa H (1982) Synthesis of forphenicinol and forphenicine. J Antibiot (Tokyo) 35:1500-1506
2. Yamamoto T, Kojiri K, Morishima H, Naganawa H, Aoyagi T, Umezawa H (1978) The structure of forphenicine. J Antibiot (Tokyo) 31:483-484
3. Okura A, Nakadaira M, Naito K, Arakawa H, Ishizuka M, Takeuchi T, Umezawa H (1987) Effect of forphenicinol on the production of lipopolysaccharide- induced interferon and tumor necrosis factor and on the growth of Meth A fibrosarcoma in mice. J Biol Response Modif 6:28-34
4. Ohhara N, Okamura S, Otsuka T, Harada M, Niho Y (1987) Stimulatory effect of forphenicinol on normal human bone marrow granulocyte-macrophage progenitor cells mediated by T-lymphocytes. Biomed Pharmacother 41:425-428
5. Ishizuka M, Ishizeki S, Masuda T, Momose A, Aoyagi T, Takeuchi T, Umezawa H (1982) Studies on effects of forphenicinol on immune responses. J Antibiot (Tokyo) 35:1042-1048
6. Hoeprich PD, Merry JM (1987) Comparative efficacy of forphenicinol, cyclosporine, and amphotericin B in experimental murine coccidiomycosis. Diagn Microbiol Infect Dis 6:287-292
7. Ishizuka M, Masuda T, Kanbayashi N, Watanabe Y, Matsuzaki M, Sawazaki Y, Ohkura A, Takeuchi T, Umezawa H (1982) Antitumor effect of forphenicinol, a low molecular weight immunomodifier, on murine transplantable tumors and microbial infections. J Antibiot (Tokyo) 35:1049-1054
8. Ishibashi T, Takamoto M, Shinoda A, Sugiyama K (1984) Fundamental and clinical studies on forphenicinol, a small-molecular immunomodulator. Jpn J Antibiot 37:185-197
9. Nitta K, Tanaka T, Takeuchi M (1985) Effect of forphenicinol, a small molecular immunomodifier, in combination with cyclophosphamide on growth of and immunity to syngeneic murine tumors. Cancer Treat Rep 69:285-291
10. Okura A, Sawazaki Y, Naito K, Ishizuka M, Takeuchi T, Umezawa H (1986) Antitumor effect of forphenicinol, a low molecular weight immunomodifier, in combination with surgery on Meth A fibrosarcoma, Lewis lung carcinoma, and adenocarcinoma 755. J Antibiot (Tokyo) 39:564-568
11. Hallahan DE, Mauceri HJ, Seung LP, Dunphy EJ, Wayne JD, Hanna NN, Toledano A, Hellman S, Kufe DW, Weichselbaum RR (1995) Spatial and temporal control of gene therapy using ionizing radiation. Nat Med 1:786-791
12. Mauceri HJ, Seung LP, Grdina WL, Swedberg KA, Weichselbaum RR (1997) Increased injection number enhances adenoviral genetic radiotherapy. Radiat Oncol Investig 5:220-226
13. Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, Bigelow K, Heimann R, Gately S, Dhanabal M, Soff GA, Sukhatme VP, Kufe DW, Weichselbaum RR (1998) Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature 394:287-291
14. Mauceri HJ, Seetharam S, Beckett MA, Lee JY, Gupta VK, Gately S, Stack MS, Brown CK, Swedberg K, Kufe DW, Weichselbaum RR (2002) Tumor production of angiostatin is enhanced after exposure to TNF-alpha. Int J Cancer 97:410-415
15. Terakado T, Saito K, Tajima K, Miyasato H, Suzuki T, Ikeda S (1983) Phase I study of forphenicinol, a new biological response modifier. Gan To Kagaku Ryoho 10:2309-2317
16. Kumano N, Nakai Y, Ishikawa T, Koinumaru S, Suzuki S, Oizumi K, Konno K (1985) Changes in the immunological parameters after a single dose of forphenicinol, a new small molecular immunomodifier. Tohoku J Exp Med 146:419-427
17. Kallman RF, Rapacchietta D, Zaghloul MS (1991) Schedule-dependent therapeutic gain from the combination of fractionated irradiation plus c-DDP and 5-FU or plus c-DDP and cyclophosphamide in C3H/Km mouse model systems. Int J Radiat Oncol Biol Phys 20:227-232