Intrapulmonary arteriovenous shunts of >15 μm in diameter probably do not contribute to arterial hypoxemia in maximally exercising Thoroughbred horses

Journal of Applied Physiology

Volumn 99, Issue 1, 2005, Pages 224-229

  Manohar, Murli ^a   Goetz, Thomas E ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Arterial desaturation during exercise; Blood gas tensions during exertion; Microspheres; Pulmonary microcirculation

Indexed keywords

HEMOGLOBIN; MICROSPHERE; OXYGEN; STABLE ISOTOPE;

ANIMAL EXPERIMENT; AORTA; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD GAS TENSION; CONTROLLED STUDY; EXERCISE; FEMALE; HEART RATE; HEMODYNAMICS; HORSE; HYPOXEMIA; LUNG ARTERIOVENOUS SHUNT; LUNG BLOOD FLOW; LUNG CIRCULATION; LUNG GAS EXCHANGE; MALE; MICROCIRCULATION; NONHUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; PULMONARY ARTERY;

ANIMALS; ANOXEMIA; ARTERIES; ARTERIOVENOUS ANASTOMOSIS; CROSS-SECTIONAL STUDIES; EXERCISE TEST; FEMALE; HORSE DISEASES; HORSES; LUNG; MALE; OXYGEN; PHYSICAL ENDURANCE; PULMONARY CIRCULATION;

EID: 21644490056     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01230.2004     Document Type: Article

References (27)

1. Bayly WM, Hodgson DR, Schultz DA, Dempsey JA, and Gollnick PD. Exercise-induced hypercapnia in the horse. J Appl Physiol 67: 1858-1966, 1989.
2. Bernard SL, Glenny RW, Erickson HH, Fedde MR, Polissar N, Basaraba RJ, and Hlastala MP. Minimal redistribution of pulmonary blood flow with exercise in racehorses. J Appl Physiol 81: 1062-1070, 1996.
3. Dempsey JA and Wagner PD. Exercise-induced arterial hypoxemia. J Appl Physiol 87: 1997-2006, 1999.
4. Dempsey JA, Sheel AW, Haverkamp HC, Babcock MA, and Harms CA. Pulmonary system limitations to exercise in health. Can J Appl Physiol 28: 2-24, 2003.
5. Eldridge MW, Dempsey JA, Haverkamp HC, Lovering AT, and Hokanson JS. Exercise-induced intrapulmonary arteriovenous shunting in healthy humans. J Appl Physiol 97: 797-805, 2004.
6. Hlastala MP, Bernard SL, Erickson HH, Fedde MR, Gaughan EM, McMurphy R, Emery MJ, Polissar N, and Glenny RW. Pulmonary blood flow distribution in standing horses is not dominated by gravity. J Appl Physiol 81: 1051-1061, 1996.
7. LaPointe JM, Vrins A, and McCarvill E. A survey of exercise-induced pulmonary hemorrhage in Quebec Standardbred racehorses. Equine Vet J 26: 482-485, 1994.
8. Lekeux P and Art T. The respiratory system: anatomy, physiology and adaptations to exercise and training. In: The Athletic Horse-Principles and Practice of Equine Spans Medicine, edited by Hodgson DR and Rose RJ. Philadelphia, PA: Saunders, 1994, p. 79-121.
9. Manohar M. Inspiratory and expiratory muscle perfusion in maximally exercised ponies. J Appl Physiol 68: 544-548, 1990.
10. Manohar M and Goetz TE. Pulmonary vascular pressures of exercising Thoroughbred horses with and without endoscopic evidence of EIPH. J Appl Physiol 81: 1589-1593, 1996.
11. Manohar M and Goetz TE. L-NAME does not affect exercise-induced pulmonary hypertension in Thoroughbred horses. J Appl Physiol 84: 1902-1908, 1998.
12. Manohar M and Goetz TE. Pulmonary vascular resistance of horses decreases with moderate exercise and remains unaffected as workload is increased to maximal exercise. Equine Vet J Suppl 30: 117-121, 1999.
13. Manohar M, Goetz TE, and Hassan AS. Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in Thoroughbred horses. J Appl Physiol 90: 2371-2377, 2001.
14. Manohar M, Goetz TE, and Hassan AS. Nitric oxide synthase inhibition does not affect the exercise-induced arterial hypoxemia in Thoroughbred horses. J Appl Physiol 91: 1105-1112, 2001.
15. Manohar M, Goetz TE, Hassan AS, DePuy T, and Humphrey S. Anti-inflammatory agent, dexamethasone does not affect exercise-induced arterial hypoxemia in Thoroughbreds. J Appl Physiol 93: 99-106, 2002.
16. Manohar M, Goetz TE, and Hassan AS. Preexercise hypervolemia does not affect arterial hypoxemia in Thoroughbreds performing short-term high-intensity exercise. J Appl Physiol 94: 2135-2144, 2003.
17. Préfaut C, Durand F, Mucci P, and Caillaud C. Exercise-induced arterial hypoxemia in athletes. Sports Med 30: 47-61, 2000.
18. Reeves JT and Taylor AE. Pulmonary hemodynamics and fluid exchange in the lung during exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 13, p. 583-613.
19. Reinhardt CP, Dahlberg S, Tries MA, Marcel R, and Leppo JA. Stable labeled microspheres to measure perfusion: validation of a neutron activation assay technique. Am J Physiol Heart Circ Physiol 280: H108-H116, 2001.
20. Shaw AM, Bunton DC, Fisher A, McGrath JC, Montgomery I, Daly C, and MacDonald A. V-shaped cushion at the origin of bovine pulmonary supernumerary arteries: structure and putative function. J Appl Physiol 87: 2348-2356, 1999.
21. Sinclair SE, McKinney S, Glenny RW, Bernard SL, and Hlastala MP. Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse. J Appl Physiol 88: 2269-2278, 2000.
22. Steel RGD and Torrie JH. Principles and Procedures in Statistics (2nd ed.). New York: McGraw Hill, 1960, p. 138-206.
23. 22a. Stickland MK, Welch RC, Haykowsky MJ, Petersen SR, Anderson WD, Taylor DA, Bouffard M, and Jones RL. Intrapulmonary shunt and pulmonary gas exchange during exercise in humans. J Physiol 561: 321-329, 2004.
24. Sweeney CR. Exercise-induced pulmonary hemorrhage. Vet Clin North Am Equine Pract 1: 93-104, 1991.
25. Wagner PD, Gillespie JR, Landgren GL, Fedde MR, Jones BW, De-Bowes RM, Pieschl RL, and Erickson HH. Mechanism of exercise-induced arterial hypoxemia in horses. J Appl Physiol 66: 1227-1233, 1989.
26. West JB, Mathieu-Costello O, Jones JH, Birks EK, Logeman RB, Pascoe JR, and Tyler WS. Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J Appl Physiol 75: 1097-1109, 1993.
27. Wilkins PA, Gleed RD, Krivitski NM, and Dobson A. Extravascular lung water in the exercising horse. J Appl Physiol 91: 2442-2450, 2001.