Methylation of the putative tumor suppressor gene, RASSF1A, in primary cervical tumors

Molekulyarnaya Biologiya

Volumn 38, Issue 6, 2004, Pages 1005-1013

  Malyukova, A V ^a   Loginov, W I ^a   Hodyrev, D S ^a   Kadyrova, E L ^a,b   Pronina, I V ^a   Ivanova, T A ^b   Kisseljov, F L ^b   Zabarovsky, E R ^c,d   Kisseljova, N P ^b   Braga, E A ^a  

^a STATE RESEARCH INSTITUTE OF GENETICS AND SELECTION OF INDUSTRIAL MICROORGANISMS   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PRIMER DNA; RASSF1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CHROMOSOME 3; DNA METHYLATION; FEMALE; GENETICS; HUMAN; MALE; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; UTERINE CERVIX TUMOR;

BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CHROMOSOMES, HUMAN, PAIR 3; DNA METHYLATION; DNA PRIMERS; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 21644483468     PISSN: 00268984     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. WHO Press Release WHO. 1996. 47.
2. Greenlee R.T., Murray T., Bolden S., Wingo P.A. 2000. Cancer statistics. CA Cancer J. Clin. 50, 7-33.
3. Smith H.O., Tiffany M.F., Quails C.R., Key C.R. 2000. The rising incidence of adenocarcinoma relative to squamous cell carcinoma of the uterine cervix in the United States - a 24-year population-based study. Gynecol. Oncol. 78, 97-105.
4. zur Hausen H. 2002. Papillomaviruses and cancer: from basic studies to clinical application. (Review). Nature Rev. Cancer. 2, 342-350.
5. Herman J.G. 1999. Hypermethylation of tumor suppressor genes in cancer. Seminars Cancer Biol. 9, 359-367.
6. Rader J.S., Kamarasova T., Huettner P.C., Li L., Li Y., Gerhard D.S. 1996. Allelotyping of all chromosomal arms in invasive cervical cancer. Oncogene. 13, 2737-2741.
7. Kisseljov F., Semjonova L., Samoylova E., Mazurenko N., Komissarova E., Zourbitskaya V., Gritzko T., Kozachenko V., Netchuskin M., Petrov S., Smirnov A., Alonso A. 1996. Instability of chromosome 6 microsatellite repeats in human cervical tumors carrying papillomavirus sequences. Int. J. Cancer. 69, 484-487.
8. Wistuba I.I., Montellano F.D., Milchgrub S., Virmani A.K., Behrens C., Chen H., Ahmadian M., Nowak J.A., Muller C., Minna J.D., Gazdar A.F. 1997. Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma. Cancer Res. 57, 3154-3158.
9. Kersemaekers A.M., Hermans J., Fleuren G.J., van de Vijver M.J. 1998. Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix. Brit. J. Cancer. 77, 192-200.
10. Mazurenko N., Attaleb M., Gritzko T., Semjonova L., Pavlova L., Sakharova O., Kisseljov F. 1999. High resolution mapping of chromosome 6 deletions in cervical cancer. Oncol. Reports. 6, 859-863.
11. Acevedo C.M., Henriquez M., Emmert-Buck M.R., Chuaqui R.F. 2002. Loss of heterozygosity on chromosome arms 3p and 6q in microdissected adenocarcinomas of the uterine cervix and adenocarcinoma in situ. Cancer. 94, 793-802.
12. Dreijerink K., Braga E., Kuzmin I., Geil L., Duh P.M., Angeloni D., Zbar B., Lerman M.I., Stanbridge E.J., Minna J.D., Protopopov A., Li J., Kashuba V., Klein G., Zabarovsky E.R. 2001. The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis. Proc. Natl. Acad. Sci. USA. 98, 7504-7509.
13. Pfeifer G.P., Yoon J.-H., Liu L., Tommasi S., Wilczynski Sh.P., Dammann R. 2002. Methylation of the RASSF1A gene in human cancers. Biol. Chem. 383, 907-914.
14. Tomizawa Y., Kohno T., Kondo H., Otsuka A., Nishioka M., Niki T., Yamada T., Maeshima A., Yoshimura K., Saito R., Minna J.D., Yokota J. 2002. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin. Cancer Res. 8, 2362-2368.
15. Muller H.M., Widschwendter A., Fiegl H., Ivarsson L., Goebel G., Perkmann E., Marth C., Widschwendter M. 2003. DNA methylation in serum of breast cancer patients: an independent prognostic marker. Cancer Res. 63, 7641-7645.
16. Kuzmin I., Liu L., Dammann R., Geil L., Stanbridge E.J., Wilczynski S.P., Lerman M.I., Pfeifer G.P. 2003. Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection. Cancer Res. 63, 1888-1893.
17. Cohen Y., Singer G., Lavie O., Dong S.M., Beller U., Sidransky D. 2003. The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix. Clin. Cancer Res. 9, 2981-2984.
18. Yu M.Y., Tong J.H., Chan P.K., Lee T.L., Chan M.W., Chan A.W., Lo K.W., To K.F. 2003. Hypermethylation of the tumor suppressor gene RASSF1A and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers. Int. J. Cancer. 105, 204-209.
19. Samoylova E., Shaikhaev G., Petrov S., Kisseljova N., Kisseljov F. 1995. HPV infection in cervical-cancer cases in Russia. Int. J. Cancer. 61, 337-341.
20. Ivanova T., Petrenko A., Gritsko T., Vinokourova S., Eshilev E., Kobzeva V., Kisseljov F., Kisseljova N. 2002. Methylation and silencing of the retinoic acid receptor-beta 2 gene in cervical cancer. BMC Cancer. 2, 4 (el).
21. Braga E., Senchenko V., Bazov I., Loginov W., Ermilova V., Kazubskaya T., Garkavtseva R., Mazurenko N., Kisseljov F., Liu J., Lerman M.I., Kisselev L., Klein G., Zabarovsky E. 2002. Critical tumor-suppressor gene regions on chromosome 3p in major human epithelial malignancies: allelotyping and quantitative real-time PCR. Int. J. Cancer. 100, 534-541.
22. Senchenko V., Liu J., Braga E., Mazurenko N., Loginov W., Seryogin Y., Bazov I., Kisseljov F., Kashuba V., Lerman M.I., Klein G., Zabarovsky E. 2003. Deletion mapping of cervical carcinomas using quantitative real-time PCR identifies two frequently affected regions in 3p21.3. Oncogene. 22, 2984-2992.
23. Toyooka S., Toyooka K.O., Maruyama R., Virmani A.K., Girard L., Miyajima K., Harada K., Arioshy Y., Takahashi T., Sugio K., Brambilla E., Gilcrease M., Minna J.D., Gazdar A.F. 2001. DNA methylation profiles of lung tumors. Mol. Cancer Ther. 1, 61-67.
24. Vos M.D., Ellis C.A., Bell A., Birrer M.J., Clark G.J. 2000. Ras uses the novel tumor suppressor RASSF1A as an effector to mediate apoptosis. J. Biol. Chem. 275, 35669-35672.
25. Shivakumar L., Minna J., Sakamaki T., Pestell R., White M.A. 2002. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol. Cell Biol. 22, 4309-4318.
26. Dammann R., Schagdarsurengin U., Strunnikova M., Rastetter M., Seidel C., Liu L., Tommasi S., Pfeifer G.P. 2003. Epigenetic inactivation of Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis. Histol. Histopathol. 18, 665-677.
27. Waki T., Tamara G., Makoto S., Motoyama T. 2003. Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples. Oncogene. 22, 4128-4133.
28. Cui H., Horon I., Oholsson R., Hamilton S., Feinberg A. 1998. Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite istability. Nature Med. 4, 1276-1280.