Increases in serum levels of troponin i are associated with cardiac dysfunction and disease severity in pediatric patients with septic shock

Pediatric Critical Care Medicine

Volumn 5, Issue 6, 2004, Pages 533-538

  Fenton, Kimberly E ^a   Sable, Craig A ^b   Bell, Michael J ^c   Patel, Kantilal M ^c   Berger, John T ^d  

^a STONY BROOK UNIVERSITY   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d Department of Critical Care Medicine ^*  (United States)

Author keywords

Cardiac dysfunction; Disease severity; Myocardial cell injury; Pediatrics; Septic shock; Troponin I

Indexed keywords

BIOLOGICAL MARKER; TROPONIN I;

ADOLESCENT; ARTICLE; BLOOD; CHILD; CLINICAL TRIAL; ECHOCARDIOGRAPHY; ECHOGRAPHY; FEMALE; HEART DISEASE; HEART MUSCLE CELL; HOSPITALIZATION; HUMAN; INFANT; INTENSIVE CARE; MALE; METABOLISM; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROSPECTIVE STUDY; SEPTIC SHOCK;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; ECHOCARDIOGRAPHY; FEMALE; HEART DISEASES; HUMANS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; MALE; MYOCYTES, CARDIAC; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; TROPONIN I;

EID: 21644464229     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/01.PCC.0000144711.97646.0C     Document Type: Article

References (39)

1. Ellrodt AG, Riedinger MS, Kimchi A, et al: Left ventricular performance in septic shock: Reversible segmental and global abnormalities. Am Heart J 1985; 110:402-409
2. Ognibene FP, Parker MM, Natanson C, et al: Depressed left ventricular performance: Response to volume infusion in patients with sepsis and septic shock. Chest 1988; 93: 903-910
3. Parker MM, Shelhamer JH, Bacharach SL, et al: Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984; 100:483-490
4. Cunnion RE, Schaer GL, Parker MM, et al: The coronary circulation in human septic shock. Circulation 1986; 73:637-644
5. Kumar A, Haery C, Parillo JE: Myocardial dysfunction in septic shock. Crit Care Clin 2000; 16:251-287
6. Vincent JL, Gris P, Coffernils M, et al: Myocardial depression characterizes the fatal course of septic shock. Surgery 1992; 111: 660-667
7. Pollack MM, Fields AI, Ruttiman UE: Distributions of cardiopulmonary variables in pediatric survivors and nonsurvivors of septic shock. Crit Care Med 1985; 13:454-459
8. Feltes TF, Pignatelli R, Kleinert S, et al: Quantitated left ventricular systolic mechanics in children with septic shock utilizing noninvasive wall stress analysis. Crit Care Med 1994; 22:1647-1658
9. Ceneviva G, Paschall JA, Maffei F, et al: Hemodynamic support in fluid refractory pediatric septic shock. Pediatrics 1998; 102:e19
10. Wilkinson JD, Pollack MM, Ruttiman UE, et al: Outcome of pediatric patients with multiple organ system failure. Crit Care Med 1986; 14:271-274
11. Courand JA, Marshall J, Chang Y, et al: Clinical applications of wall-stress analysis in the pediatric intensive care unit. Crit Care Med 2001; 29:526-533
12. Jardin F, Fourme T, Page B, et al: Persistent preload defect in severe sepsis despite fluid loading: A longitudinal echocardiographic study in patients with septic shock. Chest 1999; 116:1354-1359
13. Pulmonary Artery Consensus Conference: Consensus statement. New Horiz 1997; 5:175-194
14. Parillo JE, Burch C, Shelhamer J, et al: A circulating myocardial depressant substance in humans with septic shock. Patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 1985; 76: 1539-1553
15. Kumar A, Thota V, Dee L, et al: Tumor necrosis factor-Alpha and interleukin-1 beta are biological markers of left ventricular dysfunction in septic shock. J Exp Med 1996; 183:949-958
16. Thiru Y, Pathan N, Bignal S, et al: A myocardial cytotoxic process is involved in the cardiac dysfunction of meningococcal septic shock. Crit Care Med 2000; 28:872-877
17. Turner A, Tsamitros M, Bellamo R: Myocardial cell injury in septic shock. Crit Care Med 1999; 27:1775-1780
18. ver Elst KM, Spapen HD, Nguyen DN, et al: Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock. Clin Chem 2000; 46:650-657
19. Fernandes CJ, Akamine N, Knobel E: Cardiac troponin: A new serum marker of myocardial injury in sepsis. Intensive Care Med 1999; 25:1165-1168
20. Ammann P, Fehr T, Minder EI, et al: Elevation of troponin I in sepsis and septic shock. Intensive Care Med 2001; 27:965-969
21. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 101:1644-1655
22. Soldin SJ, Murthy JN, Agarwalla PK, et al: Pediatric reference ranges for creatine kinase, CKMB, troponin I, iron and cortisol. Clin Biochem 1999; 32:77-80
23. Schiller NB, Shah PM, Crawford M, et al: Recommendations for the quantification of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two- Dimensional Echocardiograms. J Am Soc Echocardiogr 1989; 2:358-367
24. Colan SD, Borow KM, Neumann A: Left ventricular end-systolic wall stress-velocity of fiber shortening relation: A load-independent index of myocardial contractility. JACC 1984; 4:715-724
25. Grossman W, Jones D, McLaurin LP: Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 1975; 56: 56-64
26. Pollack MM, Patel KM, Ruttiman UE: PRISM III: An updated Pediatric Risk of Mortality score. Crit Care Med 1996; 24:743-752
27. Katus HA, Scheffeld T, Remppis A, et al: Proteins of the troponin complex. Lab Med 1992; 23:311-317
28. Adams JE, Bodor GS, Davila-Roman VG, et al: Cardiac troponin I: A marker with a high specificity for cardiac injury. Circulation 1993; 1993:101-106
29. Mair J, Morandell D, Genser N, et al: Equivalent early sensitivities of myoglobin, creatine kinase, MB mass, creatine kinase isoform ratios and cardiac troponins I and T for acute myocardial infarction. Clin Chem 1995; 41: 1266-1272
30. Adams JE, Schectman KB, Landt Y, et al: Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and troponin I. Clin Chem 1994; 40: 1291-1295
31. Falahati A, Sharkey S, Christensen D, et al: Implementation of serum cardiac troponin I as a marker for detection of acute myocardial infarction. Am Heart J 1999; 137:332-337
32. Myocardial Infarction Redefined-A consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. JACC 2000; 36: 959-969
33. Antman EM, Tanasijevic MJ, Thompson B, et al: Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 1996; 335:1342-1349
34. Zimmerman J, Fromm R, Meyer D, et al: Diagnostic marker cooperative study for the diagnosis of myocardial infarction. Circulation 1999; 99:1671-1677
35. Arlati S, Brenna S, Prencipe L, et al: Myocardial necrosis in ICU patients with acute noncardiac disease: A prospective study. Intensive Care Med 2000; 26:31-37
36. Briassoulis G, Narlioglou M, Zavras N, et al: Myocardial injury in meningococcus-induced purpura fulminans in children. Intensive Care Med 2001; 27:1073-1082
37. Schiller NB, Foster E: Analysis of left ventricular systolic function. Heart 1996; 75(Suppl 2):17-26
38. Snider AR, Serwer GA, Ritter S. Echocardiography in Pediatric Heart Disease. Second Edition. St. Louis, Mosby-Year Book, 1997
39. Colan SD, Facc IA, Parness MD, et al: Developmental modulation of myocardial mechanics: Age-And growth-related alterations in afterload and contractility. JACC 1992; 19: 619-629