Formulating insulin for oral administration: Preparation of hyaluronan-insulin complex

Pharmaceutical Research

Volumn 21, Issue 11, 2004, Pages 2040-2047

  Jederstrom, Gustaf ^a,b   Andersson, Arne ^a   Gråsjö, Johan ^a   Sjöholm, Ingvar ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MCe Med AB   (Sweden)

Author keywords

Glucose lowering activity; Hyaluronan; Hyaluronan insulin complex; Insulin; Insulin formulation

Indexed keywords

ELECTROLYTE; HYALURONIC ACID; RECOMBINANT HUMAN INSULIN; ANTIDIABETIC AGENT; INSULIN; RECOMBINANT PROTEIN; ZINC;

ACIDITY; AMINO ACID ANALYSIS; ANIMAL MODEL; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG FORMULATION; DRUG SCREENING; DRUG STRUCTURE; GLUCOSE BLOOD LEVEL; HYDROPHILICITY; HYDROPHOBICITY; LIGHT SCATTERING; MALE; NONHUMAN; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; RAT; SOLID; STREPTOZOCIN DIABETES; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CHEMISTRY; EXPERIMENTAL DIABETES MELLITUS; HUMAN; LIGHT; MOLECULAR WEIGHT; ORAL DRUG ADMINISTRATION; PH; PHYSICAL CHEMISTRY; QUALITY CONTROL; RADIATION SCATTERING; SOLUBILITY; SPRAGUE DAWLEY RAT; VISCOSITY;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; HYALURONIC ACID; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INSULIN; LIGHT; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR WEIGHT; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SCATTERING, RADIATION; SOLUBILITY; VISCOSITY; ZINC;

EID: 21644446347     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000048195.69304.ff     Document Type: Article

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