Proteomics-driven identification of putative AfsR2-target proteins stimulating antibiotic biosynthesis in Streptomyces lividans

Biotechnology and Bioprocess Engineering

Volumn 10, Issue 3, 2005, Pages 248-253

  Kim, Chang Young ^a   Park, Hyun Joo ^b   Kim, Eung Soo ^a  

^a Inha University   (South Korea)

^b SongWon Envichem Inc   (South Korea)

Author keywords

AfsR2; Antibiotic regulation; Proteomics; Streptomyces

Indexed keywords

ACTINORHODINE; ANTIBIOTIC AGENT; BACTERIAL PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GUANOSINE 3' DIPHOSPHATE 5' TRIPHOSPHATE; POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE; PROTEIN AFSR2; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CONTROLLED STUDY; DOWN REGULATION; DRUG SYNTHESIS; GEL ELECTROPHORESIS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PHOSPHATE TRANSPORT; PLEIOTROPY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; PROTEOMICS; STREPTOMYCES LIVIDANS; WILD TYPE;

STREPTOMYCES; STREPTOMYCES LIVIDANS;

EID: 21644443909     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02932021     Document Type: Article

References (31)

1. Chater, K. F. (1990) Multilevel regulation of Streptomyces differentiation. Trends Genet. 5: 372-377.
2. Hopwood, D. A. (1987) Towards an understanding of gene switching in Streptomyces, the basis of sporulation and antibiotic production. Proc. R. Soc. Lond. Series B. 235: 2257-2269.
3. Nakamura Y., C. Asada, and T. Sawada (2004) Production of antibacterial violet pigment by psychrotropic bacterium RT102 strain. Biotechnol. Bioprocess Eng. 8: 37-40.
4. Champness, W. C. and K. F. Chater (1994) Regulation and integration of antibiotic production and morphological differentiation in Streptomyces spp. pp. 61-93. In: P. J. Piggot, C. P. Moran Jr., and P. Youngman (eds.). Regulation of Bacterial Differentiation. American Society for Microbiology, Washington D.C., USA.
5. Kim J. H., J. S. Lim, and S. W. Kim (2004) The improvement of cephalosporin C production by fed-batch culture of Cephalosporium acremonium M25 using rice oil. Biotechnol. Bioprocess Eng. 9: 459-464.
6. Lee, K. J. and J. Y. Lim (2004) Optimized conditions for high erythritol production by Penicillium sp. KJ-UV29, mutant of Penicillium sp. KJ81. Biocechnol. Bioprocess Eng. 8: 173-178.
7. Champness, W. C., P. Riggle, T. Adamidis, B. Kenney, and D. Aceti (1993) Genetic elements involved in global antibiotic regulation in Streptomyces coelicolor. pp. 227-233. In: R. Baltz et al. (eds.). Industrial Microorganisms: Basic and Applied Molecular Genetics. American Society for Microbiology, Washington D.C., USA.
8. Hara, O., S. Horinouchi, T. Uozumi, and T. Beppu (1983) Genetic analysis of A-factor synthesis in Streptomyces coelicolor A3(2) and Streptomyces griseus. J. Gen. Microbiol. 129: 2939-2944.
9. Horinouchi, S., O. Hara, and T. Beppu (1983) Cloning of a pleiotropic gene that positively controls biosynthesis of A-factor, actinorhodin, and prodigiosin in Streptomyces coelicolor A3(2) and Streptomyces lividans. J. Bacteriol. 155: 1238-1248.
10. Horinouchi, S., M. Kito, M. Nishiyama, K. Furuya, S. K. Hong, K. Miyake, and T. Beppu (1992) Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2). Gene 95: 49-56.
11. Stein, D. and S. N. Cohen (1989) A cloned regulatory gene of Streptomyces lividans can suppress the pigment deficiency phenotype of different development mutants. J. Bacteriol. 171: 2258-2261.
12. Vogtli, M., P. C. Chang, and S. N. Cohen (1994) afsR2: A previously undeleted gene encoding a 63-amino-acid protein that stimulates antibiotic production in Streptomyces lividans. Mol. Microbiol. 14: 643-653.
13. Matsumoto, A., H. Ishizukz, T. Beppu, and S. Horinouchi (1995) Involvement of a small ORF downstream of the afsR gene in the regulation of secondary metabolism in Streptomyces coelicolor A3(2). Actinomycetologica. 9: 37-43.
14. Kim, E.-S., H.-J. Hong, C.-Y. Choi, and S. N. Cohen (2001) Modulation of actinorhodin biosynthesis in Streptomyces lividans by glucose repression of afsR2 gene transcription. J. Bacteriol. 183: 2198-2203.
15. Kim, C.-Y., H.-J. Park, Y. J. Yoon, H.-Y. Kang, and E.-S. Kim (2004) Stimulation of actinorhodin production by Streptomyces lividans with a chromosomally-integrated antibiotic regulatory gene afsR2. J. Microbiol. Biotechnol. 14: 1089-1092.
16. Oakley, B. R., D. R. Kirsch, and N. R. Morris (1980) A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels. Anal. Biochem. 105: 361-363.
17. Shevchenko, A., M. Wilm, O. Vorm, and M. Mann (1996) Mass spectrometric sequencing of proteins from silver-stained polyacrylamide dels. Anal. Chem. 68: 850-858.
18. Kormanec, J., A. Lempel'ova, R. Novakova, B. Rezuchova, and D. Homerova (1997) Expression of the Streptomyces aureofaciens glyceraldehyde-3-phosphate dehydrogenase gene (gap) is developmentally regulated and induced by glucose. Microbiology 143: 3555-3561.
19. Sprusansky, O., B. Rezuchova, D. Homerova, and J. Kormanec (2001) Expression of the gap gene encoding glyceraldehyde-3-phosphate dehydrogenase of Streptomyces aureofaciens requires GapR, a member of the AraC/XylS family of transcriptional activators. Microbiology 147: 1291-1301.
20. Umeyama, T., A. Naruoka, and S. Horinouchi (2000) Genetic and biochemical characterization of a protein phosphatase with dual substrate specificity in Streptomyces coelicolor A3 (2). Gene 258: 55-62.
21. Vomastek, T., R. Nadvornik, J. Janecek, Z. Technikova, J. Weiser, and P. Branny (1998) Characterisation of two putative protein Ser/Thr kinases from actinomycete Streptomyces granaticolor both endowed with different properties. Eur. J. Biochem. 257: 55-61.
22. Chung, H. J., J. H. Choi, E. J. Kim, Y. H. Cho, and J. H. Roe (1999) Negative regulation of the gene for Fe-containing superoxide dismutase by an Ni-responsive factor in Streptomyces coelicolor. J. Bacteriol. 181: 7381-7384.
23. Folcher, M., H. Gaillard, L. T. Nguyen, K. T. Nguyen, P. Lacroix, N. Bamas-Jacques, M. Rinkel, and C. J. Thompson (2001) Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase. J. Biol. Chem. 276: 44297-44306.
24. Yoon, Y. J., B. J. Beck, B. S. Kim, H.-Y. Kang, and K. A. Reynolds (2002) Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chem. Biol. 9: 203-214.
25. Cashel, M., D. R. Gentry, V. J. Hernandez, and D. Vinella (1996) The stringent response. pp. 1458-1496. In: R. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Rezniko, M. Riley, M. Schaechter, and H. E. Umbarger (eds.). Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology. American Society for Microbiology, Washington, D.C., USA.
26. Martinez-Costa, O. H., P. Arias, N. M. Romero, V. Parro, R. P. Mellado, and F. Malpartida (1996) A relA/spoT homologous gene from Streptomyces coelicolor A3(2) controls antibiotic biosynthetic genes. J. Biol. Chem. 271: 10627-10634.
27. Chakraburtty, R. and M. Bibb (1997) The ppGpp synthetase gene (rel4) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation. J. Bacteriol. 179: 5854-5861.
28. Glass, R. E., S. T. Jones, and A. Ishihama (1986) Genetic studies on the β subunit of Escherichia coli RNA polymerase. VII. RNA polymerase is a target for ppGpp. Mol. Gen. Genet. 203: 265-268.
29. Ochi, K. (1987) Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: Significance of the stringent response (ppGpp) and GTP content in relation to A factor. J. Bacteriol. 169: 3608-3616.
30. Kelly, K. S., K. Ochi, and G. H. Jones (1991) Pleiotropic effects of a relC mutation in Streptomyces antibioticus. J. Bacteriol. 173: 2297-2300.
31. Sohlberg B., J. Huang, and S. N. Cohen (2003) The Streptomyces coelicolor polynucleotide phosphorylase homologue, and not the putative poly(A) polymerase, can polyadenylate RNA. J. Bacteriol. 185: 7273-7278.