Incidentally detected prostate cancer in cystoprostatectomies: Pathological and morphometric comparison with clinically detected cancer in totally embedded specimens

Human Pathology

Volumn 36, Issue 6, 2005, Pages 646-654

  Montironi, Rodolfo ^a   Mazzucchelli, Roberta ^a   Santinelli, Alfredo ^a   Scarpelli, Marina ^a   Beltran, Antonio Lòpez ^b   Bostwick, David G ^c  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^c BOSTWICK LABORATORIES   (United States)

Author keywords

Cystoprostatectomy; High grade prostatic intraepithelial neoplasia; Incidental cancer; Karyometry; Morphometry; Prostate cancer; Screening

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BLADDER CANCER; CANCER GRADING; CANCER STAGING; CANCER SURGERY; CELL PROLIFERATION; CONTROLLED STUDY; CYSTECTOMY; EMBEDDING; EPITHELIUM TUMOR; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; KARYOMETRY; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; NUCLEOLUS; PROSTATE CANCER; PROSTATE EPITHELIUM; SCORING SYSTEM;

HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; NEOPLASM STAGING; NEOPLASMS, MULTIPLE PRIMARY; PARAFFIN EMBEDDING; PROSTATECTOMY; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; URINARY BLADDER NEOPLASMS;

EID: 21544446157     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2005.03.018     Document Type: Article

References (41)

1. T.A. Stamey, F.S. Freiha, J.E. McNeal, E.A. Redwine, A.S. Whittmore, and H.P. Schmid Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer Cancer 71 1993 933 938
2. D.G. Bostwick Prostatic intraepithelial neoplasia Curr Urol Rep 1 2000 65 70
3. D.G. Bostwick, M.B. Amin, P. Dundore, W. Marsh, and D.S. Schultz Architectural patterns of high-grade prostatic intraepithelial neoplasia Hum Pathol 24 1993 298 310
4. D.G. Bostwick, R. Montironi, and I.A. Sesterhenn Diagnosis of prostatic intraepithelial neoplasia Scand J Urol Nephrol 205 Suppl. 2000 3 10
5. R. Montironi, R. Mazzucchelli, F. Algaba, and A. Lopez-Beltran Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance J Clin Pathol 53 2000 655 665
6. R. Montironi, R. Mazzucchelli, and A. Santinelli Prostatic intraepithelial neoplasia and prostate cancer Panminerva Med 44 2000 213 220
7. R. Montironi, R. Mazzucchelli, and M. Scarpelli Precancerous lesions and conditions of the prostate: from morphological and biological characterization to chemoprevention Ann N Y Acad Sci 963 2002 169 184
8. F. Abbas, S.R. Biyabani, and S. Pervez Incidental prostate cancer: the importance of complete prostatic removal at cystoprostatectomy for bladder cancer Urol Int 64 2000 52 54
9. F. Abbas, D. Hochberg, F. Civantos, and M. Soloway Incidental prostatic adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer Eur Urol 30 1996 322 326
10. F.A. Androulakakis, H.M. Schneider, G.H. Jacobi, and R. Hohenfellner Coincident vesical transitional cell carcinoma and prostatic carcinoma: clinical features and treatment Br J Urol 53 1987 153 156
11. R.J. Babaian, P. Troncoso, and A. Ayala Transurethral-resection zone prostate cancer detected at cystoprostatectomy. A detailed histologic analysis and clinical implications Cancer 67 1991 1418 1422
12. L. Cindolo, G. Benincasa, R. Autorino, S. Domizio, G. De Rosa, and G. Testa Prevalence of silent prostatic adenocarcinoma in 165 patients undergone cystoprostatectomy: a retrospective study Oncol Rep 8 2001 269 271
13. G.A. De Boccard, F. Chatelanat, and P. Graber Association de l'adenocarcinome de la prostate au carcinome transitionnel de la vessie Helv Chir Acta 20 1985 533 534
14. S.E. Denton, S.H. Choy, and W.L. Valk Occult prostatic carcinoma diagnosed by the step-section technique of the surgical specimen J Urol 93 1965 296 298
15. J.N. Kabalin, J.E. McNeal, H.M. Price, F.S. Freiha, and T.A. Stamey Incidental adenocarcinoma of the prostate in patients undergoing cystoprostatectomy for other causes: incidence, histology and morphometric observations J Urol 141 1989 1091 1094
16. A. Konski, P. Rubin, P.A. DiSantangnese, E. Mayer, H. Keys, and A. Cockett Simultaneous presentation of adenocarcinoma of prostate and transitional cell carcinoma of bladder Urology 37 1991 202 206
17. K. Matsumoto, T. Kakizoe, Y. Nishio, M. Ohtani, K. Kishi, and S. Tejima Histopathological investigation of specimens from radical total cystoprostatectomy of carcinoma of the prostate Nippon Hinyokika Gakkai Zasshi 77 1986 1429 1437
18. J.E. Montie, D.P. Wood, E. Pontes, J.M. Boyett, and H.S. Levin Adenocarcinoma of the prostate in cystoprostatectomy specimens removed for bladder cancer Cancer 63 1989 381 385
19. N. Morel Journel, A. Manel, A. Ruffion, M. Decaussin, N. Berger, and M. Devonec High prevalence of prostate cancer associated with bladder cancer Eur Urol Suppl 2 2003 339A
20. G. Moutzouris, C. Barbatis, D. Plastiras, N. Mertziotis, C. Katsifotis, and V. Presvelos Incidence and histological findings of unsuspected prostatic adenocarcinoma in radical cystoprostatectomy for transitional cell carcinoma of the bladder Scand J Urol Nephrol 33 1999 27 30
21. T.R. Pritchett, J. Moreno, N.E. Warner, G. Lieskovsky, P.W. Nichols, and B.A. Cook Unsuspected prostatic adenocarcinoma in patients who have undergone radical cystoprostatectomy for transitional cell carcinoma of the bladder J Urol 139 1988 1214 1216
22. P. Troncoso, R.J. Babaian, J.Y. Ro, D.J. Grignon, A.C. von Eschenbach, and A.G. Ayala Prostatic intraepithelial neoplasia and invasive prostatic adenocarcinoma in cystoprostatectomy specimens Urology 34 Suppl. 1989 52 56
23. H.N. Winfield, P.K. Reddy, and P.H. Lange Coexisting adenocarcinoma of the prostate in patients undergoing cystoprostatectomy for bladder cancer Urology 30 1987 100 101
24. C.R. Yang, Y.C. Ou, H.C. Ho, Y.L. Kao, C.L. Cheng, and J.T. Chen Unsuspected prostate carcinoma and prostatic intraepithelial neoplasm in Taiwanese patients undergoing cystoprostatectomy Mol Urol 3 1999 33 39
25. W.A. Sakr, S.J. Grignon, J.D. Crissman, L.K. Heilbrun, B.J. Cassin, and J.J. Pontes High grade prostatic intraepithelial neoplasia (high-grade PIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases In Vivo 8 1994 439 443
26. W.A. Sakr, G.P. Haas, B.F. Cassin, J.E. Pontes, and J.D. Crissman The frequency of carcinoma and intraepithelial neoplasia of prostate in young male patients J Urol 150 1993 379 385
27. M. Sanchez-Chapado, G. Olmedilla, M. Cabeza, E. Donat, and A. Ruiz Prevalence of prostate cancer and prostatic intraepithelial neoplasia in Caucasian Mediterranean males: an autopsy study Prostate 54 2003 238 247
28. R. Scott, D.L. Mutchnik, T.Z. Laskowski, and W.R. Schmalhorst Carcinoma of the prostate in elderly men: incidence, growth characteristics and clinical significance J Urol 101 1969 602 607
29. F. Silvestri, R. Bussani, N. Pavletic, and F. Bassan Neoplastic and borderline lesions of the prostate: an autopsy study and epidemiological data Pathol Res Pract 191 1995 908 916
30. S.R. Bott, A.A. Freeman, S. Stenning, J. Cohen, and M.C. Parkinson Radical prostatectomy: pathology findings in 1001 cases compared with other major series and over time BTU Int 95 2005 34 39
31. A. Arakawa, S. Soh, and T.M. Wheeler High-grade prostatic intraepithelial neoplasia in cystoprostatectomy specimens J Urol Pathol 7 1997 1 8
32. W. Prange, A. Erbersdobler, P. Hammerer, M. Graefen, S.H. Hautmann, and R.E. Hautmann Henke radical prostatectomy. Frequency and extent of high-grade prostatic intraepithelial neoplasia in cystoprostatectomy specimens J Urol Pathol 12 2000 65 77
33. W. Prange, A. Erbersdobler, P. Hammerer, M. Graefen, S.H. Hautmann, and R.E. Hautmann Henke radical prostatectomy. Significance of high-grade prostatic intraepithelial neoplasia in needle biopsy specimens Urology 57 2001 486 490
34. J. Qian, P. Wollan, and D.G. Bostwick The extent and multicentricity of high-grade prostatic intraepithelial neoplasia in clinically localized prostatic adenocarcinoma Hum Pathol 28 1997 143 148
35. P.H. Bartels, V. Duval da Silva, R. Montironi, P.W. Hamilton, D. Thompson, and L. Vaught Chromatin texture signature in nuclei from prostate lesions Anal Quant Cytol Histol 20 1998 407 716
36. R. Montironi, A. Longatto Filho, A. Santinelli, R. Mazzucchelli, R. Pomante, and M. Scarpelli Nuclear changes in the normal-looking columnar epithelium adjacent to and distant from prostatic intraepithelial neoplasia and prostate cancer. Morphometric analysis in whole-mount sections Virchows Arch 437 2000 625 634
37. P. Colanzi, A. Santinelli, R. Mazzucchelli, R. Pomante, and R. Montironi Changes in the normal-looking epithelium with PIN or cancer Adv Clin Path 3 1999 129 134
38. R. Montironi, P.W. Hamilton, M. Scarpelli, D. Thompson, and P.H. Bartels Subtle morphological and molecular changes in the normal-looking epithelium in prostates with prostatic intraepithelial neoplasia or cancer Eur Urol 35 1999 468 473
39. M.H. Weinstein Digital image analysis of proliferative index: two distinct population of high-grade prostatic intraepithelial neoplasia in close proximity to the adenocarcinoma of the prostate Hum Pathol 29 1998 620 626
40. E.L. Wiley, P. Davidson, D.D. McIntire, and A.I. Sagalowsky Risk of concurrent prostate cancer in cystoprostatectomy specimens is related to volume of high-grade prostatic intraepithelial neoplasia Urol 49 1997 692 696
41. J. Lapointe, J.P. Higgins, M. Van de Rijn, E. Bair, K. Montgomery, and M. Ferrari Gene expression profiling identified clinically relevant subtypes of prostate cancer Proc Natl Acad Sci U S A 101 2004 811 816