Growth hormone improves bone mineral content in children with cystic fibrosis

Journal of Pediatric Endocrinology and Metabolism

Volumn 18, Issue 6, 2005, Pages 589-595

  Hardin, Dana S ^a   Ahn, Chul ^c   Prestidge, Claude ^a   Seilheimer, Dan K ^a   Ellis, Kenneth J ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Bone mineral content; Cystic fibrosis; Growth hormone; Lean tissue mass; Osteopenia; Osteoporosis

Indexed keywords

ESTRADIOL; HUMAN GROWTH HORMONE; SEX HORMONE; SOMATOMEDIN C; TESTOSTERONE;

ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE AGE; BONE MINERAL; CASE REPORT; CAUCASIAN; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTIC FIBROSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTRADIOL BLOOD LEVEL; ETHNOLOGY; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HUMAN; LEAN BODY WEIGHT; MALE; PREPUBERTY; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; STUDENT T TEST;

EID: 21444449050     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2005.18.6.589     Document Type: Article

References (29)

1. Shane E, Silverberg SJ, Donovan D, Papadopoulos A, Staron RB, Addesso V, Jorgesen B, McGregor C, Schulman L. Osteoporosis in lung transplantation candidates with end-stage pulmonary disease. Am J Med 1996; 101: 262-269.
2. Bachrach LK, Loutit C, Moss RB. Osteopenia in adults with cystic fibrosis. Am J Med 1994; 96: 27-34.
3. Gibbens DT, Gilsanz V, Boechat MI, Dufer D, Carlson ME, Wang CI. Osteoporosis in cystic fibrosis. J Pediatr 1988; 113: 295-300.
4. Bhudhikanok GS, Choo Wang M, Marcus R, Harkins A, Moss RB, Bachrach LK. Bone acquisition and loss in children and adults with cystic fibrosis: a longitudinal study. J Pediatr 1998; 133: 18-27.
5. Aris RM, Renner JB, Winders AD, Buell HE, Riggs DB, Lester GE, Ontjes DA. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann Intern Med 1998; 128: 186-193.
6. Trotter M, Hixon BB. Sequential changes in weight, density, and percentage ash weight of human skeletons from an early fetal period through old age. Anat Rec 1973; 179: 1-8.
7. Boot AM, Keizer-Schrama SM, Pols HAP, Krenning EP, Drop SLS. Bone mineral density and body composition before and during treatment with gonadotropin-releasing hormone agonist in children with central precocious and early puberty. J Clin Endocrinol Metab 1998; 83: 370-373.
8. Ellis KJ, Abrams SA, Wong WW. Body composition of a young, multiethnic female population. Am J Clin Nutr 1997; 65: 724-731.
9. Ellis KJ. Body composition of a young, multiethnic, male population. Am J Clin Nutr 1997; 66: 1323-1331.
10. Holmes SJ, Shalet SM. role of growth hormone and sex steroid in achieving and maintaining normal bone mass. Horm Res 1996; 45: 86-93.
11. Johannesson M, Carlson ME, Bergsten Brucefors A, Hjelte L. Cystic fibrosis through a female perspective: psychosocial issues and information concerning puberty and motherhood. Patient Educ Couns 1998; 34: 115-123.
12. Byard P. The adolescent growth spurt in children with cystic fibrosis. Ann Hum Biol 1994; 21: 229-240.
13. Cystic Fibrosis Foundation. Cystic Fibrosis Foundation patient registry annual data report. Cystic Fibrosis Foundation, 2000.
14. Saggese G, Baroncelli GI, Bertelloni S, Barsanti S. The effect of long-term growth hormone (GH) treatment on bone mineral density in children with GH deficiency. Role of GH in attainment of peak bone mass. J Clin Endocrinol Metab 1996; 81: 3077-3083.
15. Hardin DS, Dyson M, Rice J, Seilheimer DK, Ellis KJ. Growth hormone improves protein catabolism in children with cystic fibrosis. J Clin Endocrinol Metab 2001; 85: 4424-4428.
16. Hardin DS, Stratton R, Kramer JC, Reyes de la Rocha S, Govaerts K, Wilson DP. Growth hormone improves weight velocity and height velocity in children with cystic fibrosis. Horm Metab Res 1998; 30: 636-641.
17. Sackey AH, Taylor CJ, Barraclough M, Wales JKH, Pickering M. Growth hormone as a nutritional adjunct in cystic fibrosis: results of a pilot study. J Hum Nutr Diet 1995; 8: 185-191.
18. Hutler M, Schnable D, Staab D, Tackey A, Wahn U, Boning D, Beneke R. Effect of growth hormone on exercise tolerance in children with CF. Med Sci Sport Exercise 2002; 34: 567-572.
19. Hardin DS, Ahn C, Dremaine D, Dyson M, Morse M, Prestidge C, Seilheimer D. Growth hormone improves height and weight in adolescents with cystic fibrosis. J Clin Endocrinol Metab 2001; 86: 4424-4428.
20. Sneppen SB, Hoeck HC, Kollerup G, Sorenson OH, Laruberg P, Feldt-Rasmussen U. Bone mineral content and bone metabolism during physiological GH treatment in GH-deficient adults - an 18 month randomized placebo controlled, double blinded trial. Eur J Endocrinol 2002; 146: 187-195.
21. Greulich WW, Pyle SI. Radiographic Atlas of Skeletal Development of the Hand and Wrist, 2nd Ed. Stanford, CA: Stanford University Press, 1959.
22. Hardin DS, Arumugam R, Seilheimer DK, LeBlanc A, Ellis KJ. Normal bone mineral density in cystic fibrosis. Arch Dis Child 2001; 84: 363-368.
23. Holt TL, Ward LC, Francis PJ, Isles A, Cooksley WGE, Shepherd RW. Whole body protein turnover in malnourished cystic fibrosis patients and its relationship to pulmonary disease. Am J Clin Nutr 1985; 41: 1061-1066.
24. Allen DB. Influence of inhaled corticosteroids on growth: a pediatric endocrinologist's perspective. Acta Paediatr 1998; 87: 123-129.
25. Borowitz D, Baker RD, Stallings V. Consensus report on nutrition for pediatric patients with cystic fibrosis. J Pediatr Gastroenterol Nutr 2002; 35: 246-259.
26. Schnabel D, Schonau E, Staab D, Tacke A, Felsenberg D, Wahn U, Grüters A. Effects of growth hormone therapy on bone metabolism in patients with cystic fibrosis (CF). Paediatr Osteol 1998; 209-217.
27. Boot AM, Engels AMJ, Boerma GJM, Krenning EP, de Muinck Keizer-Schrama SMPF. Changes in bone mineral density, body composition, and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency. J Clin Endocrinol Metab 1997; 82: 2423-2428.
28. Haworth CS, Webb AK, Egan JJ, Selby PL, Hasleton PS, Bishop PW, Freemont TJ. Bone histomorphometry in adult patients with cystic fibrosis. Chest 2000; 118: 434-439.
29. Ionescu AA, Nixon LS, Evans WD, Stone MD, Lewis-Jenkins VS, Chatham K, Shale DJ. Bone density, bone composition, and inflammatory status in cystic fibrosis. Am J Respir Crit Care Med 2000; 162: 789-794.