Specific antibodies, levofloxacin, and modulation of capsule-associated virulence in Streptococcus pneumoniae [1]

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 7, 2005, Pages 3095-3096

  Tarragó, David ^a   Lara, Noelia ^a   Fenoll, Asunción ^a   Casal, Julio ^a   Giménez, María José ^b   Aguilar, Lorenzo ^b   Sevillano, David ^b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b SCHOOL OF MEDICINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; LEVOFLOXACIN; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; AREA UNDER THE CURVE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; LETTER; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; STREPTOCOCCUS PNEUMONIAE; SURVIVAL RATE;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; AREA UNDER CURVE; BACTERIAL CAPSULES; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; OFLOXACIN; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 21444447932     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.7.3095-3096.2005     Document Type: Letter

References (6)

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3. Garcia-Olmos, M., A. Parra, G. Garcia-Calvo, C. Ponte, M. J. Gimenez, L. Aguilar, and F. Soriano. 2003. Efficacy and pharmacodynamics of gemifloxacin versus levofloxacin in guinea pig pneumococcal pneumonia induced by strains with decreased ciprofloxacin susceptibility. Int. J. Antimicrob. Agents. 21:568-573.
4. Jansen, W. T. M., J. Gootges, M. Zelle, D. V. Madore, J. Verhoef, H. Snippe, and A. F. M. Verheul. 1998. Use of highly encapsulated Streptococcus pneumoniae strains in a flow-cytometric assay for assessment of the phagocytic capacity of serotype-specific antibodies. Clin. Diagn. Lab. Immunol. 5:703-710.
5. Preston, S. L., G. L. Drusano, A. L. Herman, C. L. Fowler, A. T. Chow, B. Dornseif, V. Reichl, J. Natarajan, and M. Corrado. 1998. Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials. JAMA 279:125-129.
6. Tarragó, D., L. Aguilar, M. J. Giménez, A. Fenoll, and J. Casal. 2004. Effects of amoxicillin subinhibitory concentrations on the cross-protection developed by pneumococcal antibodies in mouse sepsis caused by an amoxicillin-resistant serotype 6B Streptococcus pneumoniae strain. Antimicrob. Agents Chemother. 48:4144-4147.