Topical administration of caroverine in somatic tinnitus treatment: Proof-of-concept study

International Tinnitus Journal

Volumn 11, Issue 1, 2005, Pages 34-37

  Ehrenberger, Klaus ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Auditory neurotoxicity; Caroverine; Eardrops; Tinnitus; Treatment

Indexed keywords

CAROVERINE; EAR DROPS; QUINOXALINE DERIVATIVE;

ADOLESCENT; ADULT; AGED; ARTICLE; AUDIOMETRY; CLINICAL TRIAL; FEMALE; GOOD CLINICAL PRACTICE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; TINNITUS; TYMPANOMETRY;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEURONS, AFFERENT; PROSPECTIVE STUDIES; QUESTIONNAIRES; QUINOXALINES; REGRESSION ANALYSIS; SYNAPSES; TINNITUS; TREATMENT OUTCOME; TYMPANIC MEMBRANE;

EID: 21444447469     PISSN: 09465448     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Ehrenberger K, Felix D. Receptor pharmacological model for inner ear therapies with emphasis on glutamate receptors: A survey. Acta Otolaryngol 115:236-240, 1995.
2. Ehrenberger K, Felix D. Glutamate receptors in afferent cochlear neurotransmission in guinea pigs. Hear Res 52:73-80, 1991.
3. Eybalin M. Neurotransmitters and neuromodulators of the mammalian cochlea. Physiol Rev 73:309-373, 1993.
4. Nordang L, Oestreicher E, Arnold W, Anniko M. Glutamate is the afferent neurotransmitter in the human cochlea. Acta Otolaryngol (Stockh) 120:359-362, 2000.
5. Pujol R, Puel J-L, Gervais D'Aldin C, Eybalin M. Pathophysiology of the glutamatergic synapses in the cochlea. Acta Otolaryngol (Stockh) 113:330-334, 1993.
6. Vasama JP, Linthicum FH Jr. Idiopathic sudden sensori-neural hearing loss: Temporal bone histopathologic study. Ann Otol Rhinol Laryngol 109:527-532, 2000.
7. Lubec G. The hydroxyl radical. From chemistry to human disease. J Invest Med 44:324-346, 1996.
8. Doble A. The role of excitotoxicity in neurodegenerative disease: Implications for therapy. Pharmacol Ther 81:163-221, 1999.
9. Ehrenberger K, Felix D. Caroverine depresses the activity of cochlear glutamate receptors in guinea pigs: In vivo model for drug-induced neuroprotection? Neuropharmacology 31:1259-1263, 1992.
10. Pujol R, Pujol J-L. Excitotoxicity, synaptic repair and functional recovery in the mammalian cochlea: A review of recent findings. Ann NY Acad Sci 884:249-254, 1999.
11. Udilova N, Kozlov AV, Bieberschulte W, et al. The antioxidant activity of Caroverine. Biochem Pharmacol 65:59-65, 2003.
12. Ehrenberger K. Clinical experience with Caroverine in inner ear diseases. Adv Otorhinolaryngol 59:156-162, 2002.
13. Juhn SK, Hunter BA, Odland RM. Blood-labyrinth barrier and fluid dynamics of the inner ear. Int Tinnitus J 7:72-83, 2001.
14. Seidmann MD. Glutamate antagonists, steroids, and antioxidants as therapeutic options for hearing loss and tinnitus and the use of an inner ear drug delivery system. Int Tinnitus J 4:148-154, 1998.
15. Newman CW, Jacobson GP, Spitzer JB. Development of the tinnitus handicap inventory. Arch Otolaryngol Head Neck Surg 122:143-148, 1996.
16. Newman CW, Wharton JA, Jacobson GP. Self focused and somatic attention in patients with tinnitus. J Am Acad Audiol 8:143-149, 1997.
17. Hiller W, Janca A, Burke KC. Association between tinnitus and somatoform disorders. J Psychosom Res 43:613-624, 1997.
18. Myrhaug H. The incidence of ear symptoms in cases of malocclusion and temporo-mandibular joint disturbances. Br J Oral Surg 2:28-32, 1964.
19. Parker WS, Chole RA. Tinnitus, vertigo, and temporo-mandibular disorders. Am J Orthod Dentofac Orthop 107:153-158, 1995.
20. Chen Z, Ulfendahl M, Ruan R, et al. Acute treatment of noise trauma with local Caroverine application in the guinea pig. Acta Otolaryngol 123:905-909, 2003.
21. Seidman MD, Van de Water TR. Pharmacologic manipulation of the labyrinth with novel and traditional agents delivered to the inner ear. Ear Nose Throat J 82:276-300, 2003.
22. Schwab B, Lenarz T, Heermann R. Use of the round window catheter for inner ear therapy-results of a placebo controlled, prospective study on chronic tinnitus. Laryngorhinootologie 83:164-172, 2004.