Gonadotropin releasing hormone analogue therapy in children with isolated growth hormone deficiency: Final height benefit from postponing puberty?

Journal of Pediatric Endocrinology and Metabolism

Volumn 18, Issue 6, 2005, Pages 535-539

  Bocca, G ^a   Bruin, N ^a   Delemarre van de Waal, H A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

GnRH analogues; Gonadal suppression; Growth hormone deficiency; Puberty

Indexed keywords

CYPROTERONE ACETATE; GONADORELIN DERIVATIVE; GROWTH HORMONE; MEDROXYPROGESTERONE ACETATE;

ADULTHOOD; ARTICLE; BODY HEIGHT; CHILD; GONAD FUNCTION; GROWTH HORMONE DEFICIENCY; HUMAN; METHODOLOGY; PREDICTION; PROGNOSIS; PUBERTY;

EID: 21444444727     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2005.18.6.535     Document Type: Article

References (23)

1. Ranke MB, Price DA, Albertsson-Wikland K, Maes M, Lindberg A. Factors determining pubertal growth and final height in growth hormone treatment of idiopathic growth hormone deficiency. Horm Res 1997; 48: 62-71.
2. Blethen SL, Baptista J, Kuntze J, Foley T, LaFranchi S, Johanson A. Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. J Clin Endocrinol Metab 1997; 82: 418-420.
3. August GP, Julius JR, Blethen SL. Adult height in children with growth hormone deficiency who are treated with biosynthetic growth hormone: the National Cooperative Growth Study experience. Pediatrics 1998; 102: 512-516.
4. Carel JC, Ecosse E, Nicolino M, Tauber M, Leger J, Cabrol S, Bastie-Sigeac I, Chaussain JL, Coste J. Adult height after long term treatment with recombinant growth hormone for idiopathic isolated growth hormone deficiency: observational follow up study of the French population based registry. Br Med J 2002; 325: 70.
5. Hibi I, Tanaka T, Tanae A, Kagawa J, Hashimoto N, Yoshizawa A, Shizume K. The influence of gonadal function and the effect of gonadal suppression treatment on final height in growth hormone (GH)-treated GH-deficient children. J Clin Endocrinol Metab 1989; 69: 221-226.
6. Tanaka T, Yoshizawa A, Tanae A, Hibi I, Shizume K. Relationships between puberty and growth at adolescence in growth-hormone-deficient males: effect of growth hormone and of associated gonadal suppression therapy. Horm Res 1990; 33 (Suppl 4): 102-105.
7. Frisch H, Bimbacher R. Final height and pubertal development in children with growth hormone deficiency after long-term treatment. Horm Res 1995; 43: 132-134.
8. Saggese G, Federico G, Barsanti S. Management of puberty in growth hormone deficient children. J Pediatr Endocrinol Metab 1999; 12: 329-334.
9. Pasquino AM, Pucarelli I, Roggini M, Segni M. Adult height in short normal girls treated with gonadotropin-releasing hormone analogs and growth hormone. J Clin Endocrinol Metab 2000; 85: 619-622.
10. Kamp GA, Mul D, Waelkens JJ, Jansen M, Delemarre-van de Waal HA, Verhoeven-Wind L, Frölich M, Oostdijk W, Wit JM. A randomized controlled trial of three years growth hormone and gonadotropin-releasing hormone agonist treatment in children with idiopathic short stature and intrauterine growth retardation. J Clin Endocrinol Metab 2001; 86: 2969-2975.
11. Mul D, Oostdijk W, Waelkens JJ, Drop SL. Final height after GnRH agonist treatment with or without addition of growth hormone in short adopted girls with early puberty. Horm Res 2004; 62 (Suppl 2): 80.
12. Heger S, Partsch CJ, Sippell WG. Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metab 1999; 84: 4583-4590.
13. Mul D, Versluis-den Bieman HJ, Slijper FM, Oostdijk W, Waelkens JJ, Drop SL. Psychological assessments before and after treatment of early puberty in adopted children. Acta Paediatr 2001; 90: 965-971.
14. Stanhope R, Brook CG. The effect of gonadotrophin releasing hormone analogue on height prognosis in growth hormone deficiency and normal puberty. Eur J Pediatr 1988; 148: 200-202.
15. Tanaka T, Satoh M, Yasunaga T, Horikawa R, Tanae A, Katsumata N, Tachibana K, Nose O, Hibi I. When and how to combine growth hormone with a luteinizing hormone-releasing hormone analogue. Acta Paediatr 1999; Suppl 428: 85-88.
16. Mul D, Wit JM, Oostdijk W, van den Broeck J. The effect of pubertal delay by GnRH agonist in GH-deficient children on final height. J Clin Endocrinol Metab 2001; 86: 4655-4656.
17. Reiter EO, Lindberg A, Ranke MB, Price DA, Albertsson-Wikland K, Cowell CT, Bakker B. The KIGS experience with the addition of gonadotropin-releasing hormone agonists to growth hormone (GH) treatment of children with idiopathic GH deficiency. Horm Res 2003; 60 (Suppl 1): 68-73.
18. Tauber M, Berro B, Delagnes V, Lounis N, Jouret B, Pienkowski C, Oliver I, Rochiccioli P. Can some growth hormone (GH)-deficient children benefit from combined therapy with gonadotropin-releasing hormone analogs and GH? Results of a retrospective study. J Clin Endocrinol Metab 2003; 88: 1179-1183.
19. Toublanc JE, Couprie C, Garnier P, Job JC. The effects of treatment combining an agonist of gonadotropin-releasing hormone with growth hormone in pubertal patients with isolated growth hormone deficiency. Acta Endocrinol (Copenh) 1989; 120: 795-799.
20. Saggese G, Cesaretti G, Andreani G, Carlotti C. Combined treatment with growth hormone and gonadotropin-releasing hormone analogues in children with isolated growth hormone deficiency. Acta Endocrinol (Copenh) 1992; 127: 307-312.
21. Satoh M, Tanaka T, Hibi I. Analysis of bone age maturation and growth velocity in isolated growth hormone (GH) deficient boys with and without gonadal suppression treatment and in GH deficient boys with associated gonadotropin deficiency. J Pediatr Endocrinol Metab 1997; 10: 615-622.
22. Mericq MV, Eggers M, Avila A, Cutler GB, Cassorla F. Near final height in pubertal growth hormone (GH)-deficient patients treated with GH alone or in combination with luteinizing hormone-releasing hormone analog: results of a prospective, randomized trial. J Clin Endocrinol Metab 2000; 85: 569-573.
23. Saggese G, Federico G, Barsanti S, Fiore L. The effect of administering gonadotropin-releasing hormone agonist with recombinant-human growth hormone (GH) on the final height of girls with isolated GH deficiency: results from a controlled study. J Clin Endocrinol Metab 2001; 86: 1900-1904.