β2-adrenergic receptor polymorphisms and response to salbutamol among Indian asthmatics

Pharmacogenomics

Volumn 6, Issue 4, 2005, Pages 399-410

  Kukreti, Ritushree ^a   Bhatnagar, Pallav ^a   B Rao, Chandrika ^a,d   Gupta, Simone ^a   Madan, Babita ^a   Das, Chinmoyee ^b   Guleria, Randeep ^b   Athavale, Amita Umesh ^c   Brahmachari, Samir Kumar ^a   Ghosh, Balaram ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c KEM HOSPITAL   (India)

^d Nicholas Piramal Research Centre   (India)

Author keywords

2 adrenergic receptor gene; Asthma; Pharmacogenetic locus; Responsiveness; Salbutamol; Single nucleotide polymorphisms

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; SALBUTAMOL;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FORCED EXPIRATORY VOLUME; GENE FREQUENCY; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; INDIA; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PROBABILITY; SINGLE NUCLEOTIDE POLYMORPHISM; SPIROMETRY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

5' UNTRANSLATED REGIONS; ADRENERGIC BETA-AGONISTS; ADULT; AGED; ALBUTEROL; ASTHMA; BRONCHODILATOR AGENTS; DNA PRIMERS; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; INDIANS, NORTH AMERICAN; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY FUNCTION TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 21444441069     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/14622416.6.4.399     Document Type: Article

References (35)

1. Beasley R. The burden of asthma with specific references to the United States. J. Allergy Clin. Immunol. 109, 482-489 (2002).
2. Pignatti PF. Trends in pharmacogenomics of drugs used in the treatment of asthma. Pharmacol. Res. 49, 343-349 (2004).
3. 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc. Natl Acad. Sci. USA 97, 10483-10488 (2000).
4. 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc. Natl Acad. Sci. USA 84, 40 (1987).
5. 2-adrenergic receptor in normal and asthmatic subjects. Am. J. Respir. Cell Mol. Biol. 8, 334-339 (1993).
6. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 33, 9414-9419 (1994).
7. 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 13, 25-33 (1995).
8. 2-adrenergic receptor regulate receptor expression. J. Clin. Invest. 102, 1927-1932 (1998).
9. 2-adrenoceptor polymorphisms and asthma diagnosis among Mexican adults. J. Allergy Clin. Immunol. 112, 1095-1100 (2003).
10. 2-adrenergic receptor pharmacogenetics. Am. J. Respir. Crit. Care Med. 161, 197-201 (2000).
11. 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet 4, 995-999 (1997).
12. 2-adrenergic receptor on the response to regular use of albuterol in asthma. Am. J. Respir. Crit. Care Med. 162, 75-80 (2000).
13. Liggett SB: Polymorphisms of the β2-adrenergic receptor. N. Engl. J. Med. 346, 536-537 (2002).
14. 2-agonist therapy. Clin. Sci. (Lond) 96, 253-259 (1999).
15. Nagarkatti R, B-Rao C, Rishi JP et al.: Association of IFNG gene polymorphism with asthma in the Indian population. J. Allergy Clin. Immunol. 110, 410-412 (2002).
16. ATS statement: Snowbird workshop on standardization of spirometry. Am. Rev. Respir. Dis. 119, 831-838 (1979).
17. American Thoracic Society. Standardization of spirometry: 1994 update. Am. J. Respir Crit. Care Med. 152, 1107-1136 (1995).
18. Udwadia FE, Sunavala JD, Shetye VM: Lung function studies in healthy Indian subjects. Jour. Assoc. Phys. Ind. 35, 491-496 (1987).
19. 2-adrenoceptor and response to Albuterol in children with and without a history of wheezing. J. Clin. Invest. 100, 3184-3188 (1997).
20. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16, 1215 (1988).
21. Salas A, Quintans B, Alvarez-Iglesias V: SnaPshot typing of mitochondrial DNA coding region variants. Methods Mol. Biol. 297, 197-208 (2004).
22. Abecasis GR, Cookson WO: GOLD: Graphical overview of linkage disequilibrium. Bioinformatics 16, 182-183 (2000).
23. Devlin B, Risch N: A comparision of linkage disequlibrium measures for fine-scale mapping. Genomics 29, 311-322 (1995).
24. Clark AG: Inference of haplotypes from PCR-amplified samples of diploid populations. Mol. Biol. Evol. 7, 111-122 (1990).
25. Nagarkatti R, B-Rao C, Vijayan V, Sharma SK, Ghosh B: Signal transducer and activator of transcription 6 haplotypes and asthma in the Indian population. Am. J. Respir. Cell Mol. Biol. 31, 317-321 (2004).
26. 2-adrenergic receptors: relevance to asthma. J. Allergy Clin. Immunol. 105, 487-492 (2000).
27. 2-adrenergic receptor polymorphisms affect airway responsiveness to salbutamol in asthmatics. J. Asthma 36, 583-590 (1999).
28. Drazen JM, Silverman EK, Lee TH: Heterogeneity of therapeutic responses in asthma. Br. Med. Bull. 56, 1054-1070 (2000).
29. 2-Adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. J. Biol. Chem. 274, 32241-32247 (1999).
30. 2-adrenergic receptor and asthma. Am. J. Respir. Crit. Care Med. 156, 156-162 (1997).
31. Ohe M, Munakata M, Hizawa N et al.: β2-adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma. Thorax 50, 353-359 (1995).
32. Lima JJ, Thomason DB, Mohamed MH, Eberle LV, Self TH, Johnson JA: Impact of genetic polymorphisms of the β2-adrenergic receptor on albuterol bonchodilator pharmacodynamics. Clin. Pharmacol. Ther. 65, 519-525 (1999).
33. Choudhry S, Ung N, Avila PC et al.: Pharmacogenetic differences in response to albuterol between Puerto Rican and Mexican asthmatics. Am. J. Respir. Crit. Care Med. 171, 563-570 (2005).
34. National Asthma Education and Prevention Program: Highlights of the expert panel report II: guidelines for the diagnosis and management of asthma. U.S. Department of Health and Human Services. Natl. Inst. Health 46-47 (1997).
35. Israel E, Chinchilli VM, Ford JG et al.: Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet 364, 1505-1512 (2004).