Correlation between occult neoplastic cells in the lymph node sinuses and recurrence in patients with curatively resected Dukes' B colorectal cancer

Oncology Reports

Volumn 10, Issue 5, 2003, Pages 1177-1181

  Mukai, Masaya ^a   Sato, Shinkichi ^a   Komatsu, Nobukazu ^a   Nishida, Tomomi ^a   Shiba, Kazuaki ^a   Ito, Isao ^a   Nakasaki, Hisao ^a   Makuuchi, Hiroyasu ^b  

^a TOKAI UNIVERSITY OISO HOSPITAL   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Colorectal cancer; Cytokeratin; Dukes' clinical stage; Immunohistochemical staining; Lymph node micrometastasis; Occult neoplastic cells

Indexed keywords

ANTIBODY; BIOLOGICAL MARKER; CAM 5.2 ANTIGEN; KERATIN;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; COLORECTAL TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; METABOLISM; METASTASIS; MORTALITY; NEOPLASM; PATHOLOGY; PROGNOSIS; RECURRENT DISEASE; TIME;

ANTIBODIES; BIOLOGICAL MARKERS; COLORECTAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LYMPHATIC METASTASIS; NEOPLASM METASTASIS; NEOPLASMS, UNKNOWN PRIMARY; PROGNOSIS; RECURRENCE; TIME FACTORS;

EID: 2142853582     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.10.5.1177     Document Type: Article

References (26)

1. Multi-Institutional Registry of Large Bowel Cancer in Japan, Vol. 23, Cases treated in 1994. Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan, 2002.
2. Dukes CE: Discussion on major surgery in carcinoma of the rectum with or without colostomy, excluding the anal canal and including the rectosignoid. Prod R Soc Med 50: 1051, 1957.
3. Dukes CE and Bussey HJR: The spread of rectal cancer and its effect on prognosis. Br J Cancer 12: 309-320, 1958.
4. Haboubi NY, Clark P, Kaftan SM and Schofield PF: The importance of combining xylene clearance and immunohistochemistry in the accurate staging of colorectal carcinoma. J R Soc Med 85: 386-388, 1992.
5. Calaluce R, Miedema BW and Yesus YW: Micrometastasis in colorectal carcinoma: a review. J Surg Oncol 67: 194-202, 1998. (Pubitemid 28134411)
6. Xu X, Roberts SA, Pasha TL and Zhang PJ: Undesirable cytokeratin immunoactivity of native nonepithelial cells in sentinel lymph nodes from patients with breast carcinoma. Arch Pathol Lab Med 124: 1310-1313, 2000.
7. Cutait R, Alves VAF, Lopes LC, Cutait DE, Borges JLA, Singer J, Da Silvia JH and Goffi FS: Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratins. Dis Colon Rectum 34: 917-920, 1991.
8. Jeffers MD, O'Dowd GM, Mulcahy H, Stagg M, O'Donoghue DP and Toner M: The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma. J Pathol 172: 183-187, 1994. (Pubitemid 24098670)
9. Broil R, Schauer V, Schimmelpenning H, Strik M, Woltmann A, Best R, Bruch H-P and Duchrow M: Prognostic relevance of occult tumor cells in lymph nodes of colorectal carcinomas. Dis Colon Rectum 40: 1465-1471, 1997. (Pubitemid 27528286)
10. Adell G, Boeryd B, Frånlund B, Sjödahl R and Håkansson L: Occurrence and prognostic importance of micrometastases in regional lymph nodes in Dukes' B colorectal carcinoma: an immunohistochemical study. Eur J Surg 162: 637-642, 1996.
11. Öberg Å, Stenling R, Tavelin B and Lindmark G: Are lymph node micrometastases of any clinical significance in Dukes stages A and B colorectal cancer? Dis Colon Rectum 41: 11244-1249, 1998.
12. Nakane PK and Pierce GB: Enzyme-labeled antibodies: preparation and application for localization of antigens. J Histochem Cytochem 14: 929-931, 1966.
13. Nakane PK and Pierce GB: Enzyme-labeled antibody for the light and electron microscopic localization of tissue antigens. J Cell Biol 33: 307, 1967.
14. Greenson JK, Isenhart CE, Rice R, Mojzisik C, Houchens D and Martin EW: Identification of occult micrometastases in pericolic lymph nodes of Dukes' B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Cancer 73: 563-569, 1994. (Pubitemid 24046594)
15. Liefers G-J, Cleton-Jansen A-M, van De Veide CJH, Hermans J, van Krieken JHJM, Cornelisse CJ and Tollenaar RAEM: Micrometastases and survival in stage II colorectal cancer. N Engl J Med 339: 223-228, 1998. (Pubitemid 28350164)
16. Isaka N, Nozue M, Doy M and Fukao K: Prognostic significance of perirectal lymph node micrometastases in Dukes' B rectal carcinoma: an immunohistochemical study by CAM 5.2. Clin Cancer Res 5: 2065-2068, 1999. (Pubitemid 29399259)
17. Nicholson AG, Marks CG and Cook MG: Effect on lymph node status of triple leveling and immunohistochemistry with CAM 5.2 on node negative colorectal carcinomas. Gut 35: 1447-1448, 1994. (Pubitemid 24310909)
18. Mukai M, Jonas S, Keeling N, Corless D, Okitsu A, Johnson K and Wastell C: The expression of MMP-7 mRNA in primary and metastatic human colorectal adenocarcinoma. Oncol Rep 2: 423-426, 1995.
19. Mukai M, Sadahiro S, Tokunaga N, Ishizu K, Itoh I, Kameya T, Ishikawa K, Iwase H, Suzuki T, Kimura T, Ishida H, Tajima T and Makukuchi H: The expression of MMP-2 and TIMP-2 in patients with colorectal adenocarcinoma invaded to the submucosal and proper muscle layer. Oncol Rep 3: 335-340, 1998. (Pubitemid 28100084)
20. Mukai M, Sadahiro S, Tokunaga N, Ishizu K, Itoh I, Kameya T, Ishikawa K, Iwase H, Suzuki T, Ishida H, Tajima T and Makukuchi H: The expression of MMP-2 and TIMP-2 in patients with colorectal adenocarcinoma: correlation with liver metastasis. Oncol Rep 6: 969-973, 1999.
21. Feinstein AR, Sosin DM and Wells CK: The Will Rogers phenomenon: stage migration and new techniques as a source of misleading statistics for survival in cancer. N Engl J Med 312: 1604-1608, 1985. (Pubitemid 15062653)
22. Bunt AMG, Hermans J, Smit VTHBM, van De Veide CJH, Fleuren GL and Bruijn JA: Surgical/pathologic stage migration confounds comparisons of gastric cancer survival rates between Japan and Western countries. J Clin Oncol 13: 19-25, 1995.
23. Mukai M, Moriya H, Himeno S, Oida Y, Mukoyama S, Nishi T, Nakasaki H, Sato S and Makuuchi H: Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases. Oncol Rep 8: 1079-1083, 2001. (Pubitemid 33758173)
24. Mukai M, Oida Y, Mukoyama S, Okamoto Y, Ito I, Nakasaki H, Kawai K, Sato S and Makuuchi H: Efficacy of combination chemotherapy for stage IV colon cancer with extensive peritoneal dissemination and multiple liver metastases: a case report. Oncol Rep 9: 1339-1343, 2002.
25. Laurie JA, Moertel CG, Fleming TR, Wieand HS, Leigh JE, Rubin J, McCormack GW, Gerstner JB, Krook JE, Malliard J, Twito DI, Morton RF, Tschetter LK and Barlow JF for the North Central Cancer Treatment Group and Mayo Clinic: Surgical adjuvant therapy of large bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil. J Clin Oncol 7: 1447-1456, 1989.
26. Moertel CG, Fleming TR, McDonald JS, Haller DG, Laurie JA, Goodman PJ, Ungerleider JS, Emerson WA, Tormey DG, Glick JH, Veeder MH and Mailliard JA: Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Eng J Med 322: 352-358, 1990. (Pubitemid 20042739)