Enantiomeric separation of ketoprofen by HPLC using Chirobiotic V CSP and vancomycin as chiral mobile phase additives

Yaoxue Xuebao

Volumn 38, Issue 3, 2003, Pages 211-214

  Ye, Xiao Xia ^a   Yu, Xiong ^a  

^a Shanghai Institute of Pharmaceutical Industry   (China)

Author keywords

Chiral mobile phase additive; Chiral stationary phase; Enantiomer; High performance liquid chromatography; Ketoprofen; Vancomycin

Indexed keywords

KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; VANCOMYCIN;

ARTICLE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; PH; STEREOISOMERISM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; KETOPROFEN; STEREOISOMERISM; VANCOMYCIN;

EID: 2142797512     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Mei ZL, Pei XP, Cai HS. The pharmacokinetic and pharmacodynamic properties of dexketoprofen [J]. Chin New Drugs J, 1998,7(5):339- 340.
2. Zao H, Mu ZD, Li HZ, et al. Separation of enantiomeric ketoprofen by pre-column chiral derivatization reversed-phase HPLC [J]. Chin Pharm J,2000,35(3):194-196.
3. Santo T, Luo J, Lim CK, et al. Enantiomeric separation and detection by high-performance liquid chromatography-mass spectrometry of 2-arylpropionic acids derivatized with benzofurazan fluorescent reagents [J]. Biomed Chromatogr, 1998,12(2):73-77.
4. Boisvert J, Caille G, Mcgilveray U, et al. Quantification of ketoprofen enantiomers in human plasma based on solid-phase extraction and enantioselective column chromatography [J]. J Chromatogr B Biomed Sci Appl, 1997,690(1-2):189-193.
5. Lovlin R, Vakily M, Jamali F. Rapid sensitive and direct chiral high-performace liquid chromatographic method for ketoprofen enantiomers [J]. J Chromatogr B Biomed Appl, 1996,679(1-2):196-198.
6. Armstrong DW, Tang YB, Chen SS, et al. Macrocylic antiobiotics as a new class of chiral selectors for liquid chromatography [J]. Anal Chem., 1994,66(9):1473-1478.