Intradermal concentration of hydroquinone after application of hydroquinone ointments is higher than its cytotoxic concentration

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 9, 2003, Pages 1365-1367

  Matsubayashi, Teruhisa ^a   Sakaeda, Toshiyuki ^a   Kita, Tomoko ^a   Kurimoto, Yoshie ^a   Nakamura, Tsutomu ^a   Nishiguchi, Kohshi ^a   Fujita, Takuya ^b   Kamiyama, Fumio ^b   Yamamoto, Akira ^b   Okumura, Katsuhiko ^a  

^a KOBE UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cytotoxicity; Hydroquinone; Intradermal concentration; Ointment

Indexed keywords

ASCORBIC ACID; GLYCEROL; HYDROQUINONE; OINTMENT BASE; SODIUM SULFITE; ANTIOXIDANT; HYDROQUINONE DERIVATIVE; SODIUM SULFATE; SULFATE;

ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEPIGMENTATION; DERMIS; DRUG EFFICACY; DRUG EXPOSURE; EPIDERMIS; IN VITRO STUDY; MALE; NONHUMAN; OINTMENT; RAT; SKIN FIBROBLAST; SKIN IRRITATION; SKIN PERMEABILITY; SKIN PIGMENTATION; SKIN TOXICITY; STRATUM CORNEUM; ANIMAL; CELL CULTURE; COLORIMETRY; CYTOLOGY; DIFFUSION; DRUG EFFECT; FIBROBLAST; METABOLISM; SKIN; SKIN ABSORPTION; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CELL SURVIVAL; CELLS, CULTURED; COLORIMETRY; DIFFUSION; FIBROBLASTS; HYDROQUINONES; MALE; OINTMENTS; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SULFATES;

EID: 2142710029     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.26.1365     Document Type: Article

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