Resolution of trans-3-aminocyclohexanol

Tetrahedron Asymmetry

Volumn 15, Issue 9, 2004, Pages 1451-1455

  Bernardelli, Patrick ^b   Bladon, Michael ^a   Lorthiois, Edwige ^b   Manage, Ajith C ^a   Vergne, Fabrice ^b   Wrigglesworth, Roger ^b  

^a EVOTEC UK LTD   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXANOL DERIVATIVE;

ANALYTIC METHOD; ARTICLE; CHEMICAL PROCEDURES; CHEMICAL REACTION; ENANTIOMER; ENANTIOSELECTIVITY; PRIORITY JOURNAL; TRANS ISOMER;

EID: 2142694345     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetasy.2004.03.034     Document Type: Article

References (10)

1. Vergne, F.; Ducrot, P.; Andrianjara, C.; Bernardelli, P.; Lorthiois, E. PCT Int. Appl. WO 0228847 A1, 2002
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3. Burford R.R., Hewgill F.R., Jefferies P.R. J. Chem. Soc. 1957;2937-2942
4. Burckhardt U., Grob C.A., Kiefer H.R. Helv. Chim. Acta. 50:1967;231-244
5. Traynelis V.J., Ddura J.G. J. Org. Chem. 1961;1813-1817
6. Johnson A.P., Luke R.W.A., Boa A.N. J. Chem. Soc., Perkin Trans. 1. 1996;895-905
7. Bartoli G., Cristina C., Palmieri G. J. Chem. Soc., Perkin Trans. 1. 1994;537-543
8. Greenhill J.V., Ramli M., Tomassini T. J. Chem. Soc., Perkin Trans. 1. 6:1975;588-591
9. 3. Determination of the absolute configuration is based on the refinement of the Flack parameters
10. 1H NMR analysis indicated this crude product was a mixture of the desired benzamide and benzoic acid). This crude material was used directly for analysis (chiral HPLC)