Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human fibroblasts by anthocyanidins

Bioscience, Biotechnology and Biochemistry

Volumn 67, Issue 6, 2003, Pages 1391-1393

  Kaneko, Takao ^a   Tahara, Shoichi ^a   Baba, Naomichi ^b  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Anthocyanidin; Cytotoxicity; Human fibroblasts; Linoleic acid hydroperoxide; Lipid peroxide

Indexed keywords

ANTHOCYANIN; ANTIOXIDANT; CYANIDIN; LINOLEIC ACID; LINOLEIC ACID HYDROPEROXIDE; LIPID PEROXIDE; PELARGONIDIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; FIBROBLAST; HUMAN;

ANTHOCYANINS; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; FIBROBLASTS; HUMANS; LINOLEIC ACIDS; LIPID PEROXIDES; REACTIVE OXYGEN SPECIES;

EID: 2142691752     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.67.1391     Document Type: Article

References (18)

1. Harman, D., Free radical theory of aging. Mutat. Res., 275, 257-266 (1992).
2. Kaneko, T., Kaji, K., and Matsuo, M., Cytotoxicities of a linoleic acid hydroperoxide and its related aliphatic aldehydes toward cultured human umbilical vein endothelial cells. Chem. Biol. Interact., 67, 295-304 (1988).
3. Kaneko, T., Honda, S., Nakano, S., and Matsuo, M., Lethal effects of a linoleic acid hydroperoxide and its autoxidation products, unsaturated aliphatic aldehydes, on human diploid fibroblasts. Chem. Biol. Interact., 63, 127-137 (1987).
4. Tsuda, T., Shiga, K., Ohshima, K., Kawakishi, S., and Osawa, T., Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthoc-yanin pigments isolated from Phaseolus vulgaris L. Biochem. Pharmacol., 52, 1033-1039 (1996).
5. Torel, J., Cillard, J., and Cillard, P., Antioxidant activity of flavonoids and reactivity with peroxy radical. Phytochemistry, 25, 383-385 (1986).
6. −. Free Rad-ic. Biol. Med., 11, 1-8 (1991).
7. Yamamoto, K., Kaji, K., Kondo, H., Matsuo, M., Shibata, Y., Tasaki, Y., Utakoji, T., and Ooka, H., A new human male diploid cell strain, TIG-7: its age-related changes and comparison with a matched female TIG-1 cell strain. Exp. Gerontol., 26, 525-540 (1991).
8. Ishiyama, M., Shiga, M., Sasamoto, K., Mizoguchi, M., and He, P.-G., A new sulfonated tetrazolium salt that produces a highly water-soluble formazan dye. Chem. Pharm. Bull., 41, 1118-1122 (1993).
9. Afanas’ev, I. B., Dorozhko, A. I., Brodskii, A. V., Kostyuk, V. A., and Potapovitch, A. I., Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem. Pharmacol., 38, 1763-1769 (1989).
10. Ratty, A. K., and Das, N. P., Effects of flavonoids on nonenzymatic lipid peroxidation: structure-activity relationship. Biochem. Med. Metab. Biol., 39, 69-79 (1988).
11. Bors, W., Heller, W., Michel, C., and Saran, M., Radical chemistry of flavonoid antioxidants. Adv. Exp. Med. Biol., 264, 165-170 (1990).
12. Bors, W., Heller, W., Michel, C., and Saran, M., Flavonoids as antioxidants: determination of radical-scavenging efficiencies. Methods Enzymol., 186, 343-355 (1990).
13. Brouillard, R., Flavonoids and flower color. In “The Flavonoids”, ed. Harborne, J. B., Chapman and Hall, London, pp. 525-538 (1988).
14. Tsuda, T., Ohshima, O., Kawakishi, S., and Osawa, T., Oxidation products of cyanidin 3-O-b-D-glucoside with a free radical initiator. Lipids, 31, 1259-1263 (1996).
15. Tsuda, T., Horio, F., and Osawa, T., Absorption and metabolism of cyanidin 3-O-b-D-glucoside in rats. FEBSLett., 449, 179-182 (1999).
16. Kajiya, K., Ichiba, M., Kuwabara, M., Kumazawa, S., and Nakayama, T., Role of lipophilicity and hydrogen peroxide formation in the cytotoxicity of flavonols.Biosci. Biotechnol. Biochem., 65,1227-1229 (2001).
17. Long, L. H., Clement, M. V., and Halliwell, B., Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quer-cetin to commonly used cell culture media. Biochem. Biophys. Res. Commun., 273, 50-53 (2000).
18. Kaneko, T., and Baba, N., Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity. Biosci. Biotechnol. Biochem., 63, 323-328 (1999).