메뉴 건너뛰기




Volumn 100, Issue SUPPL. 2, 1998, Pages 93-98

Success stories in structure-based drug design

Author keywords

[No Author keywords available]

Indexed keywords


EID: 2142641658     PISSN: 00315362     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1)

References (19)
  • 1
    • 11644328584 scopus 로고
    • Systematic Analysis of Structural Data as a Research Technique in Organic Chemistry
    • ALLEN F A, KENNARD O, TAYLOR R 1983 Systematic Analysis of Structural Data as a Research Technique in Organic Chemistry. Acc Chem Res 16: 146-153
    • (1983) Acc Chem Res , vol.16 , pp. 146-153
    • Allen, F.A.1    Kennard, O.2    Taylor, R.3
  • 2
    • 0017184784 scopus 로고
    • Compounds Designed to Fit a Site of Known Structure in Human Hemoglobin
    • BEDDELL C R, GOODFORD P J, NORRINGTON F E 1976 Compounds Designed to Fit a Site of Known Structure in Human Hemoglobin. Br J Phamac 57: 201-209
    • (1976) Br J Phamac , vol.57 , pp. 201-209
    • Beddell, C.R.1    Goodford, P.J.2    Norrington, F.E.3
  • 3
    • 0030474049 scopus 로고    scopus 로고
    • What Can We Learn from Molecular Recognition in Protein-Ligand Complexes for the Design of New Drugs?
    • BÖHM H J, KLEBE G 1996 What Can We Learn From Molecular Recognition in Protein-Ligand Complexes for the Design of New Drugs? Angew Chem Int Ed Engl 35: 2588-2614
    • (1996) Angew Chem Int Ed Engl , vol.35 , pp. 2588-2614
    • Böhm, H.J.1    Klebe, G.2
  • 5
    • 0017584729 scopus 로고
    • Design of Potent Competitive Inhibitors of Angiotensin-Converting Enzyme. Carboxyalkanoyl and Mercaptoalkanoyl Amino Acids
    • CUSHMAN D W, CHEUNG H S, SABO E F, ONDETTI M A 1977 Design of Potent Competitive Inhibitors of Angiotensin-Converting Enzyme. Carboxyalkanoyl and Mercaptoalkanoyl Amino Acids. Biochemistiy 16: 5484-5491
    • (1977) Biochemistiy , vol.16 , pp. 5484-5491
    • Cushman, D.W.1    Cheung, H.S.2    Sabo, E.F.3    Ondetti, M.A.4
  • 6
    • 0021356123 scopus 로고
    • Drug Design by the Method of Receptor Fit
    • GOODFORD P 1984 Drug Design by the Method of Receptor Fit. J Med Chem 27: 557-564
    • (1984) J Med Chem , vol.27 , pp. 557-564
    • Goodford, P.1
  • 7
    • 0021871375 scopus 로고
    • A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important
    • GOODFORD P 1985 A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important Macromolecules 28: 849-857
    • (1985) Macromolecules , vol.28 , pp. 849-857
    • Goodford, P.1
  • 8
    • 0022785324 scopus 로고
    • Protein Crystallography and Computer Graphics - Toward National Drug Design
    • HOL W G J 1986 Protein Crystallography and Computer Graphics - Toward National Drug Design. Angew Chem Int Ed Engl 25: 767-778
    • (1986) Angew Chem Int Ed Engl , vol.25 , pp. 767-778
    • Hol, W.G.J.1
  • 9
    • 13344270889 scopus 로고    scopus 로고
    • Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase
    • JONES T R, VARNEY M D, WEBBER S E et al. 1996 Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase. J Med Chem 39: 904-917
    • (1996) J Med Chem , vol.39 , pp. 904-917
    • Jones, T.R.1    Varney, M.D.2    Webber, S.E.3
  • 10
    • 0028057975 scopus 로고
    • Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
    • LAM P Y S, JADHAV P K, EYERMANN C J et al. 1994 Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors. Science 263: 380-384
    • (1994) Science , vol.263 , pp. 380-384
    • Lam, P.Y.S.1    Jadhav, P.K.2    Eyermann, C.J.3
  • 14
    • 0028873745 scopus 로고
    • Design of Novel, Nonpeptidic Thrombin Inhibitors and Structure of a Thrombin-Inhibitor Complex
    • OBST U, GRAMLICH V, DEDERICH F, WEBER L, BANNER D W 1995 Design of Novel, Nonpeptidic Thrombin Inhibitors and Structure of a Thrombin-Inhibitor Complex. Angew Chem Int Ed Engl 34: 1739-1742
    • (1995) Angew Chem Int Ed Engl , vol.34 , pp. 1739-1742
    • Obst, U.1    Gramlich, V.2    Dederich, F.3    Weber, L.4    Banner, D.W.5
  • 15
    • 0001214167 scopus 로고
    • Structure-Based Drug Design (SBDD): Every Structure Tells a Story
    • REICH S H, WEBBER S E 1993 Structure-Based Drug Design (SBDD): Every Structure Tells a Story. Persp Drug Discov Design 1: 371-390
    • (1993) Persp Drug Discov Design , vol.1 , pp. 371-390
    • Reich, S.H.1    Webber, S.E.2
  • 16
    • 0026589385 scopus 로고
    • Design and Synthesis of Novel 6,7-Imidazotetrahydroquinoline Inhibitors of Thymidylate Synthase Using Iterative Protein Crystal Structure Analysis
    • REICH S H, FUHRY M A, NGUYEN D et al. 1992 Design and Synthesis of Novel 6,7-Imidazotetrahydroquinoline Inhibitors of Thymidylate Synthase Using Iterative Protein Crystal Structure Analysis. J Med Chem 35: 847-858
    • (1992) J Med Chem , vol.35 , pp. 847-858
    • Reich, S.H.1    Fuhry, M.A.2    Nguyen, D.3
  • 17
    • 0026764592 scopus 로고
    • Protein Targets for Structure-based Drug Design
    • WALKINSHAW M D 1992 Protein Targets for Structure-based Drug Design. Med Res Rev 12: 317-372
    • (1992) Med Res Rev , vol.12 , pp. 317-372
    • Walkinshaw, M.D.1
  • 18
    • 0028986487 scopus 로고
    • A Test for Drug-Design Methodologies
    • WEST M L, FAIRLIE D P 1995 A Test for Drug-Design Methodologies. Trends Pharm Sci 16: 67-74
    • (1995) Trends Pharm Sci , vol.16 , pp. 67-74
    • West, M.L.1    Fairlie, D.P.2
  • 19
    • 0027403420 scopus 로고
    • Design of Thymidylate Synthase Inhibitors Using Protein Crystal Structures: The Synthesis and Biological Evaluation of a Novel Class of 5-Substituted Quinazolinones
    • WEBBER S E, BLECKMAN T M, ATTARD J et al. 1993 Design of Thymidylate Synthase Inhibitors Using Protein Crystal Structures: The Synthesis and Biological Evaluation of a Novel Class of 5-Substituted Quinazolinones. J Med Chem 36: 733-746
    • (1993) J Med Chem , vol.36 , pp. 733-746
    • Webber, S.E.1    Bleckman, T.M.2    Attard, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.