-
1
-
-
11644328584
-
Systematic Analysis of Structural Data as a Research Technique in Organic Chemistry
-
ALLEN F A, KENNARD O, TAYLOR R 1983 Systematic Analysis of Structural Data as a Research Technique in Organic Chemistry. Acc Chem Res 16: 146-153
-
(1983)
Acc Chem Res
, vol.16
, pp. 146-153
-
-
Allen, F.A.1
Kennard, O.2
Taylor, R.3
-
2
-
-
0017184784
-
Compounds Designed to Fit a Site of Known Structure in Human Hemoglobin
-
BEDDELL C R, GOODFORD P J, NORRINGTON F E 1976 Compounds Designed to Fit a Site of Known Structure in Human Hemoglobin. Br J Phamac 57: 201-209
-
(1976)
Br J Phamac
, vol.57
, pp. 201-209
-
-
Beddell, C.R.1
Goodford, P.J.2
Norrington, F.E.3
-
3
-
-
0030474049
-
What Can We Learn from Molecular Recognition in Protein-Ligand Complexes for the Design of New Drugs?
-
BÖHM H J, KLEBE G 1996 What Can We Learn From Molecular Recognition in Protein-Ligand Complexes for the Design of New Drugs? Angew Chem Int Ed Engl 35: 2588-2614
-
(1996)
Angew Chem Int Ed Engl
, vol.35
, pp. 2588-2614
-
-
Böhm, H.J.1
Klebe, G.2
-
5
-
-
0017584729
-
Design of Potent Competitive Inhibitors of Angiotensin-Converting Enzyme. Carboxyalkanoyl and Mercaptoalkanoyl Amino Acids
-
CUSHMAN D W, CHEUNG H S, SABO E F, ONDETTI M A 1977 Design of Potent Competitive Inhibitors of Angiotensin-Converting Enzyme. Carboxyalkanoyl and Mercaptoalkanoyl Amino Acids. Biochemistiy 16: 5484-5491
-
(1977)
Biochemistiy
, vol.16
, pp. 5484-5491
-
-
Cushman, D.W.1
Cheung, H.S.2
Sabo, E.F.3
Ondetti, M.A.4
-
6
-
-
0021356123
-
Drug Design by the Method of Receptor Fit
-
GOODFORD P 1984 Drug Design by the Method of Receptor Fit. J Med Chem 27: 557-564
-
(1984)
J Med Chem
, vol.27
, pp. 557-564
-
-
Goodford, P.1
-
7
-
-
0021871375
-
A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important
-
GOODFORD P 1985 A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important Macromolecules 28: 849-857
-
(1985)
Macromolecules
, vol.28
, pp. 849-857
-
-
Goodford, P.1
-
8
-
-
0022785324
-
Protein Crystallography and Computer Graphics - Toward National Drug Design
-
HOL W G J 1986 Protein Crystallography and Computer Graphics - Toward National Drug Design. Angew Chem Int Ed Engl 25: 767-778
-
(1986)
Angew Chem Int Ed Engl
, vol.25
, pp. 767-778
-
-
Hol, W.G.J.1
-
9
-
-
13344270889
-
Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase
-
JONES T R, VARNEY M D, WEBBER S E et al. 1996 Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase. J Med Chem 39: 904-917
-
(1996)
J Med Chem
, vol.39
, pp. 904-917
-
-
Jones, T.R.1
Varney, M.D.2
Webber, S.E.3
-
10
-
-
0028057975
-
Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
-
LAM P Y S, JADHAV P K, EYERMANN C J et al. 1994 Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors. Science 263: 380-384
-
(1994)
Science
, vol.263
, pp. 380-384
-
-
Lam, P.Y.S.1
Jadhav, P.K.2
Eyermann, C.J.3
-
11
-
-
0025311258
-
Structure, Multiple Site Binding, and Segmental Accomodation in Thymidylate Synthase on Binding UMP and Anti-Folate
-
MONTFORT W R, PERRY K M, FAUMAN E B, FINER MOORE J S, MALEY G F, HARDY F, MARLEY F, STROUD R M 1990 Structure, Multiple Site Binding, and Segmental Accomodation in Thymidylate Synthase on Binding UMP and Anti-Folate. Biochemistry 29: 6964-6977
-
(1990)
Biochemistry
, vol.29
, pp. 6964-6977
-
-
Montfort, W.R.1
Perry, K.M.2
Fauman, E.B.3
Finer Moore, J.S.4
Maley, G.F.5
Hardy, F.6
Marley, F.7
Stroud, R.M.8
-
14
-
-
0028873745
-
Design of Novel, Nonpeptidic Thrombin Inhibitors and Structure of a Thrombin-Inhibitor Complex
-
OBST U, GRAMLICH V, DEDERICH F, WEBER L, BANNER D W 1995 Design of Novel, Nonpeptidic Thrombin Inhibitors and Structure of a Thrombin-Inhibitor Complex. Angew Chem Int Ed Engl 34: 1739-1742
-
(1995)
Angew Chem Int Ed Engl
, vol.34
, pp. 1739-1742
-
-
Obst, U.1
Gramlich, V.2
Dederich, F.3
Weber, L.4
Banner, D.W.5
-
15
-
-
0001214167
-
Structure-Based Drug Design (SBDD): Every Structure Tells a Story
-
REICH S H, WEBBER S E 1993 Structure-Based Drug Design (SBDD): Every Structure Tells a Story. Persp Drug Discov Design 1: 371-390
-
(1993)
Persp Drug Discov Design
, vol.1
, pp. 371-390
-
-
Reich, S.H.1
Webber, S.E.2
-
16
-
-
0026589385
-
Design and Synthesis of Novel 6,7-Imidazotetrahydroquinoline Inhibitors of Thymidylate Synthase Using Iterative Protein Crystal Structure Analysis
-
REICH S H, FUHRY M A, NGUYEN D et al. 1992 Design and Synthesis of Novel 6,7-Imidazotetrahydroquinoline Inhibitors of Thymidylate Synthase Using Iterative Protein Crystal Structure Analysis. J Med Chem 35: 847-858
-
(1992)
J Med Chem
, vol.35
, pp. 847-858
-
-
Reich, S.H.1
Fuhry, M.A.2
Nguyen, D.3
-
17
-
-
0026764592
-
Protein Targets for Structure-based Drug Design
-
WALKINSHAW M D 1992 Protein Targets for Structure-based Drug Design. Med Res Rev 12: 317-372
-
(1992)
Med Res Rev
, vol.12
, pp. 317-372
-
-
Walkinshaw, M.D.1
-
18
-
-
0028986487
-
A Test for Drug-Design Methodologies
-
WEST M L, FAIRLIE D P 1995 A Test for Drug-Design Methodologies. Trends Pharm Sci 16: 67-74
-
(1995)
Trends Pharm Sci
, vol.16
, pp. 67-74
-
-
West, M.L.1
Fairlie, D.P.2
-
19
-
-
0027403420
-
Design of Thymidylate Synthase Inhibitors Using Protein Crystal Structures: The Synthesis and Biological Evaluation of a Novel Class of 5-Substituted Quinazolinones
-
WEBBER S E, BLECKMAN T M, ATTARD J et al. 1993 Design of Thymidylate Synthase Inhibitors Using Protein Crystal Structures: The Synthesis and Biological Evaluation of a Novel Class of 5-Substituted Quinazolinones. J Med Chem 36: 733-746
-
(1993)
J Med Chem
, vol.36
, pp. 733-746
-
-
Webber, S.E.1
Bleckman, T.M.2
Attard, J.3
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