Overlapping gene mutations of hepatitis B virus in a chronic hepatitis B patient with hepatitis B surface antigen loss during lamivudine therapy

Journal of Korean Medical Science

Volumn 20, Issue 3, 2005, Pages 433-437

  Lee, Sun Young ^a,b   Moon, Seok Choi ^a   Lee, Dongho ^a   Joon, Hyoek Lee ^a   Kwang, Cheol Koh ^a   Seung, Woon Paik ^a   Byung, Chul Yoo ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

Author keywords

Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Lamivudine; Mutation

Indexed keywords

ISOLEUCINE; LAMIVUDINE; MEMBRANE ANTIGEN; METHIONINE;

ADULT; AMINO ACID SUBSTITUTION; ANAMNESIS; ARTICLE; BLOOD ANALYSIS; CASE REPORT; CHRONIC HEPATITIS; CLINICAL FEATURE; DNA PROBE; GENE DELETION; GENE MUTATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LABORATORY DIAGNOSIS; MALE; NUCLEOTIDE SEQUENCE; SEQUENCE ANALYSIS;

EID: 21344468160     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.2005.20.3.433     Document Type: Article

References (29)

1. Michael ML, Tillers P. Structure and expression of the hepatitis B virus genome. Hepatology 1987; 7: 61-3.
2. Carman WF, Zanetti AR, Karayiannis P, Waters J, Manzillo G, Tanzi E, Zuckerman AJ, Thomas HC. Vaccine induced escape mutant of hepatitis B virus. Lancet 1990; 336: 325-9.
3. Milich DR, Chen M, Schodel F, Peterson DL, Jones JE, Hughes JL. Role of B cells in antigen presentation of the hepatitis B core. Proc Natl Acad Sci USA 1997; 94: 14648-53.
4. Conjeevaram HS, Lok AS. Occult hepatitis B virus infection: a hidden menace? Hepatology 2001; 34: 204-6.
5. Chaudhuri V, Tayal R, Nayak B, Acharya SK, Panda SK. Occult hepatitis B virus infection in chronic liver disease: full-length genome and analysis of mutant surface promoter. Gastroenterology 2004; 127: 1356-71.
6. Rodriguez-Inigo E, Mariscal L, Bartolome J, Castillo I, Navacerrada C, Ortiz-Movilla N, Pardo M, Carreno V. Distribution of hepatitis B virus in the liver of chronic hepatitis C patients with occult hepatitis B virus infection. J Med Virol 2003; 70: 571-80.
7. Gunther S, Fischer L, Pult I, Sterneck M, Will H. Naturally occurring variants of hepatitis B virus. Adv Virus Res 1999; 52: 25-137.
8. Lee KM, Kim YS, Ko YY, Yoo BM, Lee KJ, Kim JH, Hahm KB, Cho SW. Emergence of vaccine-induced escape mutant of hepatitis B virus with multiple surface gene mutations in a Korean child. J Korean Med Sci 2001; 16: 359-62.
9. Waters JA, Kennedy M, Voet P, Hauser P, Petre J, Carman W, Thomas HC. Loss of common 'a' determinant of hepatitis B surface antigen by a vaccine-induced escape mutant. J Clin Invest 1992; 90: 2543-7.
10. Harrison TJ, Hopes EA, Oon CJ, Zanetti AR, Zuckerman AJ. Independent emergence of a vaccine-induced escape mutant of hepatitis B virus. J Hepatol 1991; 13: S105-7.
11. Karthigesu VD, Allison LM, Fortuin M, Mendy M, Whittle HC, Howard CR. A novel hepatitis B virus variant in the sera of immunized children. J Gen Virol 1994; 75 (Pt2): 443-8.
12. McMahon G, Ehrlich PH, Moustafa ZA, McCarthy LA, Dottavio D, Tolpin MD, Nadler PI, Ostberg L. Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody-treated liver transplant patients. Hepatology 1992; 15: 757-66.
13. Okamoto H, Yano K, Nozaki Y, Matsui A, Miyazaki H, Yamamoto K, Tsuda F, Machida A, Mishiro S. Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine. Pediatr Res 1992; 32: 264-8.
14. Kato J, Hasegawa K, Torii N, Yamaguchi K, Hayashi N. A molecular analysis of viral persistence in surface antigen-negative chronic hepatitis B. Hepatology 1996; 23: 389-95.
15. Chiou HL, Lee TS, Kuo J, Mau YC, Ho MS. Altered antigenecity of 'a' determinant variants of hepatitis B virus. J Gen Virol 1997; 78: 2639-45.
16. Gaillard RK, Barnard J, Lopez V, Hodges P, Bourne E, Johnson L, Allen MI, Condreay P, Miller WH, Condreay LD. Kinetic analysis of wild-type and YMDD mutant hepatitis B virus polymerases and effects of deoxyribonucleotide concentrations on polymerase activity. Antimicrob Agents Chemother 2002; 46: 1005-13.
17. Doo E, Liang TJ. Molecular anatomy and pathophysiologic implications of drug resistance in hepatitis B virus infection. Gastroenterology 2001; 120: 1000-8.
18. Rozanov M, Plikat U, Chappey C, Kochergin A, Tatusova T. A web-based genotyping resource for viral sequences. Nucleic Acids Res 2004; 32 (Web Server issue): W654-9.
19. Jongerius JM, Wester M, Cuypers HT, van Oostendorp WR, Lelie PN, van der Poel CL, van Leeuwen EF. New hepatitis B virus mutant from in a blood donor that is undetectable in several hepatitis B surface antigen screening assays. Transfusion 1998; 38: 56-9.
20. 145 to Ala in the surface antigen gene. Med Sci Monit 2000; 6: 1165-9.
21. Fan YF, Lu CC, Chang YC, Chang TT, Lin PW, Lei HY, Su IJ. Identification of a pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection. J Gastroenterol Hepatol 2000; 15: 519-28.
22. Weinberger KM, Bauer T, Bohm S, Jilg W. High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum. J Gen Virol 2000; 81 (Pt5): 1165-74.
23. Blum HE, Liang TJ, Galun E, Wands JR. Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection. Hepatology 1991; 14: 56-63.
24. Fan YF, Lu CC, Chen WC, Yao WJ, Wang HC, Chang TT, Lei HY, Shiau AL, Su IJ. Prevalence and significance of hepatitis B virus (HBV) pre-S mutations in serum and liver at different replicative stages of chronic HBV infection. Hepatology 2001; 33: 277-86.
25. Huang ZM, Yen TS. Dysregulated surface gene expression from disrupted hepatitis B genomes. J Virol 1993; 67: 7032-40.
26. Persing DH, Varmus HE, Ganem D. Inhibition of secretion of hepatitis B surface antigen by related presurface polypeptide. Science 1986; 234: 1388-90.
27. Xu Z, Yen TS. Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles. J Virol 1996; 70: 133-40.
28. Xu Z, Jesen G, Yen TS. Activation of hepatitis B virus S promoter by viral large surface protein via induction stress in the endoplasmic reticulum. J Virol 1997; 71: 7387-92.
29. Matsuda M, Suzuki F, Suzuki Y, Tsubota A, Akuta N, Hosaka T, Someya T, Kobayashi M, Saitoh S, Arase Y, Satoh J, Kobayashi M, Ikeda K, Miyakawa Y, Kumada H. YMDD mutants in patients with chronic hepatitis B before treatment are not selected by lamivudine. J Med Virol 2004; 74: 361-6.