Effects of oral administration of levothyroxine sodium on serum concentrations of thyroid gland hormones and responses to injections of thyrotropin-releasing hormone in healthy adult mares

American Journal of Veterinary Research

Volumn 66, Issue 6, 2005, Pages 1025-1031

  Sommardahl, Carla S ^a   Frank, Nicolas ^a   Elliott, Sarah B ^a   Webb, Latisha L ^a   Refsal, Kent R ^b   Denhart, Joseph W ^c   Thompson Jr , Donald L ^d  

^a UNIVERSITY OF TENNESSEE   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c Lloyd Inc   (United States)

^d LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE SODIUM; LIOTHYRONINE; PROTIRELIN; THYROID HORMONE; THYROTROPIN; THYROXINE;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DOSE REGIMEN; DRUG EFFECT; EUTHYROIDISM; EXPERIMENTAL DESIGN; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HORSE; NONHUMAN; RANK SUM TEST; THYROID HORMONE BLOOD LEVEL; WEIGHT REDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HORSES; THYROID GLAND; THYROID HORMONES; THYROTROPIN-RELEASING HORMONE; THYROXINE; TIME FACTORS;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 21344450104     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.1025     Document Type: Article

References (27)

1. Frank N, Sojka JE, Messer NT. Equine thyroid dysfunction. Vet Clin North Am Equine Pract 2002;18:305-319.
2. Chen CL, McNulty ME, McNulty PK, et al. Serum levels of thyroxine and triiodothyronine in mature horses following oral administration of synthetic thyroxine (Synthyroid®). Equine Vet Sci 1984;4:5-6.
3. Vischer CM, Foreman JH, Constable PD, et al. Hemodynamic effects of thyroidectomy in sedentary horses. Am J Vet Res 1999;60:14-21.
4. Mandel SJ, Brent GA, Larsen PR. Levothyroxine therapy in patients with thyroid disease. Ann Intern Med 1993; 119:492-502.
5. Breuhaus BA. Thyroid-stimulating hormone in adult euthyroid and hypothyroid horses. J Vet Intern Med 2002;16:109-115.
6. Johnson PJ, Messer NT, Ganjam VK, et al. Effects of propylthiouracil and bromocriptine on serum concentrations of thyrotropin and thyroid hormones in normal female horses. Equine Vet J 2003; 35:296-301.
7. Beech J, Garcia M. Hormonal response to thyrotropin-releasing hormone in healthy horses and in horses with pituitary adenoma. Am J Vet Res 1985;46:1941-1943.
8. Chen CL, Li OW. Effect of thyrotropin releasing hormone (TRH) on serum levels of thyroid hormones in thoroughbred mares. Equine Vet Sci 1986;6:58-61.
9. Sojka JE, Johnson MA, Bottoms GD. Serum triiodothyronine, total thyroxine, and free thyroxine concentrations in horses. Am J Vet Res 1993;54:52-55.
10. Ramirez S, Wolfsheimer KJ, Moore RM, et al. Duration of effects of phenylbutazone on serum total thyroxine and free thyroxine concentrations in horses. J Vet Intern Med 1997; 11:371-374.
11. Messer NT, Johnson PJ, Refsal KR, et al. Effect of food deprivation on baseline iodothyronine and cortisol concentrations in healthy, adult horses. Am J Vet Res 1995;56:116-121.
12. Sticker LS, Thompson DL, Gentry LR. Pituitary hormone and insulin responses to infusion of amino acids and N-methyl-D,L-aspartate in horses. J Anim Sci 2001;79:735-744.
13. National Research Council. Nutrient requirements, deficiencies, and excesses. In: National Research Council nutrient requirements of horses. 5th ed. Washington, DC: National Academy Press, 1989;2-31.
14. Iossa S, Lionetti L, Mollica MP, et al. Fat balance and serum leptin concentrations in normal, hypothyroid, and hyperthyroid rats. Int J Obes 2001;24:417-425.
15. Oppenheimer JH, Schwartz HL, Lane JT, et al. Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. J Clin Invest 1991;87:125-132.
16. Woeber KA. Update on the management of hyperthyroidism and hypothyroidism. Arch Fam Med 2000;9:743-747.
17. Nachreiner RF, Refsal KR. Radioimmunoassay monitoring of thyroid hormone concentrations in dogs on thyroid replacement therapy: 2,674 cases (1985-1987). J Am Vet Med Assoc 1992;201:623-629.
18. Shapiro LE, Sievert R, Ong L, et al. Minimal cardiac effects in asymptomatic athyreotic patients chronically treated with thyrotropin-suppressive doses of L-thyroxine. J Clin Endocrinol Metab 1997;82:2592-2595.
19. Toft AD. Thyroxine therapy. N Engl J Med 1994;331:174-180.
20. Toribio RE, Duckett WM. Thyroid gland. In: Reed SM, Bayly WM, Sellon DC, eds. Equine internal medicine. 2nd ed. Philadelphia: WB Saunders Co, 2004;1340-1356.
21. Breuhaus BA. Thyroid function in mature horses ingesting endophyte-infected fescue seed. J Am Vet Med Assoc 2003;223:340-345.
22. Samuels MH, Veldhuis JD, Ridgway EC. Pathophysiology of pulsatile and copulsatile release of thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, and alpha-subunit. J Clin Endocrinol Metab 1990;71:425-432.
23. Greenspan FS. The thyroid gland. In: Greenspan FS, Strewler GJ, eds. Basic and clinical endocrinology. Stamford, Conn: Appleton & Lange, 1997;192-262.
24. Panciera DL, Ritchey JW, Ward DL. Endotoxn-induced (sic) nonthyroidal illness in dogs. Am J Vet Res 2003;64:229-234.
25. Umpierrez GE. Euthyroid sick syndrome. South Med J 2002;95:506-513.
26. Harris P, Marlin D, Gray J. Equine thyroid function tests: a preliminary investigation. Br Vet J 1992;148:71-80.
27. Hegedüs L, Nygaard B, Mølholm Hansen J. Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified? J Clin Endocrinol Metab 1999;84:756-760.