Where's the utility in Bayesian data-monitoring of clinical trials?

Clinical Trials

Volumn 2, Issue 3, 2005, Pages 197-205

  Ashby, Deborah ^a   Tan, Say Beng ^b,c  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^c Clinical Trials and Epidemiology Research Unit   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BAYES THEOREM; CANCER THERAPY; CLINICAL TRIAL; DECISION MAKING; ESOPHAGUS CANCER; EVIDENCE BASED MEDICINE; HUMAN; PRIORITY JOURNAL; PROFESSIONAL STANDARD; PUBLIC HEALTH; STATISTICAL ANALYSIS; STATISTICAL PARAMETERS;

ALGORITHMS; ANTINEOPLASTIC AGENTS; BAYES THEOREM; CHEMOTHERAPY, ADJUVANT; CLINICAL TRIALS; CLINICAL TRIALS DATA MONITORING COMMITTEES; DATA INTERPRETATION, STATISTICAL; DECISION MAKING; ESOPHAGEAL NEOPLASMS; EVIDENCE-BASED MEDICINE; HUMANS; MODELS, STATISTICAL; POSTOPERATIVE COMPLICATIONS; PUBLIC HEALTH; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 21344447080     PISSN: 17407745     EISSN: None     Source Type: Journal    
DOI: 10.1191/1740774505cn088oa     Document Type: Article

References (27)

1. Ellenberg SS, Fleming T, DeMets DL. Data monitoring committees in clinical Trials. New York: Wiley and Sons, 2002.
2. Freedman L, Anderson G, Kipnis V et al. Approaches to monitoring the results of long-term disease prevention trials: examples from the women's health initiative. Controlled Clinical Trials 1996; 17: 509-25.
3. Spiegelhalter DJ, Freedman LS, Parmar MKB. Bayesian approaches to randomized trials. Journal of the Royal Statistical Society 1994; 157: 357-416.
4. Whitehead J. The design and analysis of sequential clinical trials, 2nd edn. New York: Wiley, 1997.
5. Pocock SJ. Size of cancer clinical trials and stopping rules. British Journal of Cancer 1978; 38: 757-66.
6. Geller NL, Pocock SJ. Interim analyses in randomised clinical trials: ramifications and guidelines for practitioners. Biometrics 1987; 43: 213-23.
7. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979; 35: 549-56.
8. Berry DA, Wolff MC, Sack D. Public health decision making: a sequential vaccine trial. In Bernardo JM, Dawid P, Smith AFM eds. Bayesian Statistics 4. Oxford: Oxford University Press, 1992: 79-96.
9. Bellman R. Dynamic programming. Princeton NJ: Princeton University Press, 1957.
10. Parmigiani G. Modeling in medical decision making. A Bayesian approach. Chichester: Wiley, 2002.
11. Lewis RJ. Bayesian hypothesis testing: interim analysis of a clinical trial evaluating phenytoin for the phrophylaxis of early-post traumatic seizures in children. In Berry DA, Stangl DK eds. Bayesian biostatistics. New York: Marcel Dekker, 1996: 279-96.
12. Qian W, Brown PJ. Bayes sequential decision theory in clinical trials. In Bernardo JM, Dawid AP, Smith AFM eds. Bayesian Statistics 6. Oxford: Clarendon Press, 1999: 829-38.
13. Carlin BP, Kadane JB, Gelfand AE. Approaches for optimal sequential decision analysis in clinical trials. Biometrics 1998; 54: 964-75.
14. Parmar MKB, Spiegelhalter DJ, Freedman LS. The CHART trials: Bayesian design and monitoring in practice. Statistics in Medicine 1994; 13: 1297-312.
15. Fayers PM, Ashby D, Parmar MKB. Bayesian data monitoring in clinical trials. Statistics in Medicine 1997; 16: 1413-30.
16. Lee PM. Bayesian statistics: an introduction, 3rd edn. London: Arnold, 2004.
17. Ashby D, Smith AFM. Evidence based medicine as Bayesian decision-making. Statistics in Medicine 2000; 19: 3291-305.
18. Tan SB, Smith AFM. Exploratory thoughts on clinical trials with utilities. Statistics in Medicine 1998; 17: 2771-91.
19. Medical Research Council Oesophageal Cancer Working Party. Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial. The Lancet 2002; 359: 1733.
20. Parmar MKB, Griffiths GO, Spiegelhalter DJ, Souhami RL, Altman DG, van der Scheuren E. Monitoring of large randomised clinical trials: a new approach with Bayesian methods. The Lancet 2001; 358: 375-81.
21. Tan SB, Chung YFA, Tai BC, Cheung YB, Machin D. Elicitation of prior distributions for a phase III randomised controlled trial of adjuvant therapy with surgery for hepatocellular carcinoma. Controlled Clinical Trials 2003; 24: 110-21.
22. Raiffa H, Schlaifer R. Applied statistical decision theory. Boston: Harvard University Press, 1961.
23. Lindley DV. The choice of sample size. The Statistician 1977; 46: 129-38.
24. Spiegelhalter DJ, Smith AFM. Decision analysis and clinical decisions. In Bithell JF, Coppi R eds. Perspectives in medical statistics. London: Academic Press, 1981: 103-31.
25. Simes RJ. Application of statistical decision theory to treatment choices: implications for the design and analysis of clinical trial. Statistics in Medicine 1986; 5: 411-20.
26. Simes RJ. Treatment selection for cancer patients: application of statistical decision theory to the treatment of advanced ovarian cancer. Journal of Chronic Diseases 1985; 38: 171-86.
27. Lenert LA, Cher DJ, Goldstein MK, Bergen MR, Garber A. The effect of search procedures on utility elicitations. Medical Decision Making 1998; 18: 76-83.