Influence of epoietinum therapy on the oxidative stress in haemodialysis patients

Nephron - Clinical Practice

Volumn 100, Issue 4, 2005, Pages

  Mircescu, Gabriel ^a   Cǎpuşǎ, Cristina ^a   Stoian, Irina ^a   Mǎrǎcine, Magda ^a   Muscurel, Corina ^a   Gârneaţǎ, Liliana ^a   Bǎrbulescu, Carmen ^a  

^a CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Antioxidants; Epoietinum; Haemodialysis; Oxidative stress; Reactive species generation; Renal anaemia

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; HEMOGLOBIN; IRON; RECOMBINANT ERYTHROPOIETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; HEMODIALYSIS; HUMAN; IRON THERAPY; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

EID: 21344445930     PISSN: 16602110     EISSN: None     Source Type: Journal    
DOI: 10.1159/000085441     Document Type: Article

References (22)

1. Canaud B, Cristol JP, Morena M, Leray-Moragues H, Bosc JY, Vaussenat F: Imbalance of oxidants and antioxidants in haemodialysis patients. Blood Purif 1999;17:99-106.
2. Himmelfarb J, Hakim RM: Oxidative stress in uraemia. Curr Opin Nephrol Hypertens 2003;12:593-598.
3. Sommerburg O, Grune T, Hampl H, Riedel E, van Kuijk FJ, Ehrich JH, Siems WG: Does long-term treatment of renal anaemia with recombinant erythropoietin influence oxidative stress in haemodialysed patients? Nephrol Dial Transplant 1998;13:2583-2587.
4. Besarab A: Iron and cardiac disease in the end-stage renal disease setting. Am J Kidney Dis 1999;34(suppl 2):S18-S24.
5. Roob JM, Khoschsorur G, Tiran A, Horina JH, Holzer H, Winklhofer-Roob BM: Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis. J Am Soc Nephrol 2000;11:539-549.
6. Herrera J, Nava M, Romero F, Rodriguez-Iturbe B: Melatonin prevents oxidative stress resulting from iron and erythropoietin administration. Am J Kidney Dis 2001;37:750-757.
7. Lim PS, Wei YH, Yu YL, Kho B: Enhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy. Nephrol Dial Transplant 1999;14:2680-2687.
8. Usberti M, Gerardi G, Bufano G, Tira P, Micheli A, Albertini A, Floridi A, Di Lorenzo D, Galli F: Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patients. Am J Kidney Dis 2002;40:590-599.
9. Cristol JP, Bosc JY, Badiou S, Leblanc M, Lorrho R, Descomps B, Canaud B: Erythropoietin and oxidative stress in haemodialysis: Beneficial effects of vitamin E supplementation. Nephrol Dial Transplant 1997;12:2312-2317.
10. Luciak M, Pawlicki L, Kedziora J, Trznadel K, Blaszczyk J, Buczynski A: Whole blood superoxide anion generation and efficiency of some erythrocyte antioxidant systems during recombinant human erythropoietin therapy of uraemic anemia. Free Radic Biol Med 1991;10:397-401.
11. Nguyen-Khoa T, Massy ZA, De Bandt JP: Oxidative stress and haemodialysis: Role of inflammation and duration of dialysis treatment. Nephrol Dial Transplant 2001;16:335-340.
12. Inal M, Kanbak G, Sen S, Akyuz F, Sunal E: Antioxidant status and lipid peroxidation in hemodialysis patients undergoing erythropoietin and erythropoietin-vitamin E combined therapy. Free Radic Res 1999;31:211-216.
13. Gene S, Akhisaroglu M, Kuralay F, Gene K: Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine- induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro. Neurosci Lett 2002;321:73-76.
14. Esterbauer H, Cheeseman KH: Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990;186:407-421.
15. Rice-Evans CA, Diplock AT, Symons MCR: Techniques in Free Radicals Research. Amsterdam, Elsevier, 1991, pp 207-234.
16. Beutler E, Duron O, Kelly BM: Improved method for the determination of blood glutathione. J Lab Clin Med 1963;61:882-888.
17. Ursini F, Maiorino M, Brigelius-Flohe R, Aumann KD, Roveri A, Schomburg D, Flohe L: Diversity of glutathione peroxidases. Methods Enzymol 1995;252:38-53.
18. Aebi H: Catalase in vitro. Methods Enzymol 1984;105:121-126.
19. Marklund S, Marklund G: Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469-474.
20. Mydlik M, Derzsiova K, Racz O, Sipulova A, Lovasova E, Petrovicova J: A modified dialyzer with vitamin E and antioxidant defense parameters. Kidney Int 2001;59(suppl 78):S144-S147.
21. Raman Rao SV, Indira K: Glutathione metabolism in uremic rat. Drug Chem Toxicol 1997;20:229-237.
22. Sommerburg O, Grune T, Ehrich JHH, Siems WG: Adaptation of glutathione-peroxidase activity to oxidative stress occurs in children but not in adult patients with end-stage renal failure undergoing hemodialysis. Clin Nephrol 2002;58(suppl 1):S31-S36.