Response surface methodology and Taguchi's approach for the optimization of in vitro indomethacin release from topical hydrogels

Pharmacia

Volumn 52, Issue 1-2, 2005, Pages 147-150

  Ghica, Mihaela ^a,b   Popa, L ^a   Moisescu, St ^a  

^a CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b NONE   (Romania)

Author keywords

Hydrogels; Optimization; Taguchi

Indexed keywords

2 PROPANOL; CARBOXYMETHYLCELLULOSE; GLYCEROL; INDOMETACIN;

ARTICLE; CHEMICAL INTERACTION; CONTROLLED RELEASE FORMULATION; DIFFUSION COEFFICIENT; DRUG DIFFUSION; HYDROGEL; IN VITRO STUDY; METHODOLOGY; SIGNAL NOISE RATIO;

EID: 21244498984     PISSN: 04280296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Babar, A. et al. Piroxicam release from dermatological bases: in vitro studies using cellulose membrane and hairless mouse skin. - Drug Dev. Ind. Pharm., 16, 1990, No 3, 523-540.
2. Chang, H. C. et al. Development of a topical suspension containing three active ingredients. - Drug Dev. Ind. Pharm., 28, 2002, No 1, 29-39.
3. Hatim, S. A. et S. Adel. Optimization of methacrylic acid ester copolymers blends as controlled coatings using response surface methodology. - Pharm. Dev. Tech., 8, 2003, No 1, 87-96.
4. Palmieri, G. F. et P. Wehrle. Evaluation of ethylcellulose-coated pellets optimized using the approach of Taguchi. - Drug Dev. Ind. Pharm., 23, 1997, No 11, 1069-1077.
5. Shah, V. P. et al. Evaluation of the test system used for in vitro release of drugs for topical dermatological drug products, Pharm. Dev. Tech. 4(3), 1999, 377-385.
6. Shawesh, A. M. et al. Pluronic F-127 gels as a vehicle for topical formulations of indomethacin and rheological behaviour of these formulations. - Pharmazie, 587, 2002, No 3, 186-190
7. Xu, G. J. et al. A research on aspirin sustained-release formulation. - Drug Dev. Ind. Pharm., 23, 1997, No 8, 741-747.
8. Yamaguchi, Y. et al. Drug release test to assess quality of topical formulations in japanese market. - Drug Dev. Ind. Pharm., 22, 1996, No 7, 569-577.