Quantifying levels of p53 mutation in mouse skin tumors

Environmental and Molecular Mutagenesis

Volumn 45, Issue 5, 2005, Pages 427-434

  Verkler, Tracie L ^a   Couch, Letha H ^a   Howard, Paul C ^a   Parsons, Barbara L ^a,b  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b Division of Genetic and Reproductive Toxicology   (United States)

Author keywords

Allele specific amplification; Allele specific competitive blocker PCR; Mutation; p53; Skin neoplasm

Indexed keywords

ADENINE; BIOLOGICAL MARKER; CYTOSINE; GUANINE; PROTEIN P53; THYMINE;

ALLELE; ANIMAL TISSUE; ARTICLE; CODON; CONTROLLED STUDY; CPG ISLAND; DNA SEQUENCE; GENE MUTATION; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; SKIN TUMOR; SOLAR RADIATION;

ANIMALS; CODON; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; FLUORESCENCE; GENES, P53; GENETIC MARKERS; MICE; MICE, MUTANT STRAINS; MUTATION; NEOPLASMS, RADIATION-INDUCED; POLYMERASE CHAIN REACTION; RADIATION, NONIONIZING; SKIN NEOPLASMS;

ANIMALIA;

EID: 21244498628     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.20108     Document Type: Article

References (38)

1. Ananthaswamy HN, Fourtanier A, Evans RL, Tison S, Medaisko C, Ullrich SE, Kripke ML. 1998. p53 mutations in hairless SKH-hr1 mouse skin tumors induced by a solar simulator. Photochem Photobiol 67:227-232.
2. Armstrong BK, Kricker A. 2001. The epidemiology of UV induced skin cancer. J Photochem Photobiol B Biol 63:8-18.
3. Berg RJ, van Kranen HJ, Rebel HG, de Vries A, van Vloten WA, Van Kreijl CF, van der Leun JC, de Gruijl FR. 1996. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. Proc Natl Acad Sci USA 93:274-278.
4. Commision Internationale de l'Eclairage. 1998. Erythema reference action spectrum and standard erythema dose. Vienna: Commision Internationale de l'Eclairage.
5. de Gruijl FR, Forbes PD. 1995. UV-induced skin cancer in a hairless mouse model. Bioessays 17:651-660.
6. de Gruijl FR, van der Leun JC. 2002. Physical variables in experimental photocarcinogenesis and quantitative relationships between stages of tumor development. Front Biosci 7:1.
7. Denissenko MF, Chen JX, Tang MS, Pfeifer GP. 1997. Cytosine methylation determines hot spots of DNA damage in the human P53 gene. Proc Natl Acad Sci USA 94:3893-3898.
8. Diepgen TL, Mahler V. 2002. The epidemiology of skin cancer. Br J Dermatol 61:1-6.
9. Diffey BL, Jansen CT, Urbach F, Wulf HC. 1997. The Standard erythema dose: a new photobiological concept. Photodermatol Photoimmunol Photomed 13:64-66.
10. Dumaz N, van Kranen HJ, de Vries A, Berg RJ, Wester PW, van Kreijl CF, Sarasin A, Daya-Grosjean L, de Gruijl FR. 1997. The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice. Carcinogenesis 18:897-904.
11. Howard PC, Sams RL II, Bucher JR, Allaben WT. 2002. Phototoxicology and photocarcinogenesis at the U.S. Food and Drug Administration's National Center for Toxicological Research. J Food Drug Analysis 10:252-257.
12. International Agency for Research on Cancer. 2001. IARC TP53 database. Lyon:International Agency for Research on Cancer.
13. Kress S, Sutter C, Strickland PT, Mukhtar H, Schweizer J, Schwarz M. 1992. Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin. Cancer Res 52:6400-6403.
14. Kwok S, Kellogg DE, McKinney N, Spasic D, Goda L, Levenson C, Sninsky JJ. 1990. Effects of primer-template mismatches on the polymerase chain reaction: human immunodeficiency virus type 1 model studies. Nucl Acids Res 18:999-1005.
15. Leffell DJ. 2000. The scientific basis of skin cancer. J Am Acad Dermatol 42(1 Pt 2):18-22.
16. Liu Q, Wang Y, Crist KA, Wang ZY, Lou YR, Huang MT, Conney AH, You M. 1998. Effect of green tea on p53 mutation distribution in ultraviolet B radiation-induced mouse skin tumors. Carcinogenesis 19:1257-1262.
17. McKinzie PB, Parsons BL. 2002. Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR. Mutat Res 517:209-220.
18. Milner J, Medcalf EA. 1991. Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Cell 65:765-774.
19. Moore DE. 2002. Drug-induced cutaneous photosensitivity: incidence, mechanism, prevention and management. Drug Safety 25:345-372.
20. Nakazawa H, English D, Randell PL, Nakazawa K, Martel N, Armstrong BK, Yamasaki H. 1994. UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement. Proc Natl Acad Sci USA 91:360-364.
21. Ota I, Ohnishi K, Takahashi A, Yane K, Kanata H, Miyahara H, Ohnishi T, Hosoi H. 2000. Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma. Int J Radiat Oncol Biol Phys 47:495-501.
22. Ouhtit A, Nakazawa H, Armstrong BK, Kricker A, Tan E, Yamasaki H, English DR. 1998. UV-radiation-specific p53 mutation frequency in normal skin as a predictor of risk of basal cell carcinoma. J Natl Cancer Inst 90:523-531.
23. Parsons BL, Heflich RH. 1997. Genotypic selection methods for the direct analysis of point mutations. Mutat Res 387:97-121.
24. Parsons BL, Heflich RH. 1998. Detection of a mouse H-ras codon 61 mutation using a modified allele-specific competitive blocker PCR genotypic selection method. Mutagenesis 13:581-588.
25. Parsons BL, Culp SJ, Manjanatha MG, Heflich RH. 2002. Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression. Carcinogenesis 23:943-948.
26. Parsons BL, McKinzie PB, Heflich RH. 2005. ACB-PCR detection of rare base substitutions. In: Keohavong P, editor. Molecular toxicology protocols. Totowa, NJ: Humana Press.
27. Queille S, Seite S, Tison S, Medaisko C, Drougard C, Fourtanier A, Sarasin A, Daya-Grosjean L. 1998. p53 mutations in cutaneous lesions induced in the hairless mouse by a solar ultraviolet light simulator. Mol Carcinogen 22:167-174.
28. Rebel H, Mosnier LO, Berg RJ, Westerman-de Vries A, van Steeg H, van Kranen HJ, de Gruijl FR. 2001. Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity. Cancer Res 61:977-983.
29. Sams RL II, Couch LH, Miller BJ, Okerberg CV, Warbritton A, Wamer WG, Beer JZ, Howard PC. 2001. Basal cell proliferation in female SKH-1 mice treated with alpha- and beta-hydroxy acids. Toxicol Appl Pharmacol 175:76-82.
30. Sarasin A. 1999. The molecular pathways of ultraviolet-induced carcinogenesis. Mutat Res 428:5-10.
31. Stratton SP. 2001. Prevention of non-melanoma skin cancer. Curr Oncol Rep 3:295-300.
32. Tommasi S, Denissenko MF, Pfeifer GP. 1997. Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases. Cancer Res 57:4727-4730.
33. Tornaletti S, Pfeifer GP. 1995. Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers. Oncogene 10:1493-1499.
34. Tornaletti S, Pfeifer GP. 1996. UV damage and repair mechanisms in mammalian cells. Bioessays 18:221-228.
35. van Kranen HJ, de Gruijl FR, de Vries A, Sontag Y, Wester PW, Senden HC, Rozemuller E, van Kreijl CF. 1995. Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice. Carcinogenesis 16:1141-1147.
36. Yoon JH, Lee CS, O'Connor TR, Yasui A, Pfeifer GP. 2000. The DNA damage spectrum produced by simulated sunlight. J Mol Biol 299:681-693.
37. You YH, Szabo PE, Pfeifer GP. 2000. Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors. Carcinogenesis 21:2113-2117.
38. Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE. 1993. Mutation hot spots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Natl Acad Sci USA 90:4216-4220.