Effects of bone morphogenetic protein-2 gene therapy on the bone-implant interface: An experimental study with dogs

National Medical Journal of China

Volumn 85, Issue 22, 2005, Pages 1521-1525

  Yan, Meng Ning ^a   Tang, Ting Ting ^a   Zhu, Zhen An ^a   Zhou, Xin She ^a   Jia, Qing Wei ^a   Yu, Chao Feng ^a   Lou, Jue Ren ^a   Dai, Ke Rong ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Arthroplasty, replacement; Bone morphogenetic proteins; Gene therapy; Osseointegration

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2;

ADENOVIRUS; ADSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMECHANICS; BONE DEFECT; BONE MARROW TRANSPLANTATION; BONE PROSTHESIS; BONE RADIOGRAPHY; BONE STRENGTH; BONE TISSUE; BONE TRANSPLANTATION; CONNECTIVE TISSUE; CONTROLLED STUDY; DOG; DRUG EFFICACY; EXPERIMENTAL DESIGN; FEMUR CONDYLE; FREEZE DRYING; GENETIC TRANSFECTION; HEALING; HISTOPATHOLOGY; MORPHOMETRICS; NONHUMAN; OSSIFICATION; SOFT TISSUE; STATISTICAL SIGNIFICANCE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONE TRANSPLANTATION; CELLS, CULTURED; DOGS; FEMUR; GENE THERAPY; IMPLANTS, EXPERIMENTAL; MALE; OSSEOINTEGRATION; PROSTHESES AND IMPLANTS; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 21244493582     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Lieberman JR, Daluiski A, Stevenson S, et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on the repair of segmental femoral defects in rats. J Bone Joint Surg, 1999,81A:905-917.
2. Dai KR, Xu XL, Tang TT, et al. BMP-2 gene modified tissue-engineered bone repairing segmental tibial bone defects in goats. Natl Med J China, 2003,83:1345-1349.
3. Matin K, Senpuku H, Hanada N, et al. Bone regeneration by recombinant human bone morphogenetic protein-2 around immediate implants: a pilot study in rats. Int J Oral Maxillofac Implants, 2003, 18:211-217.
4. Sykaras N, Triplett RG, Nunn ME, et al. Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants. Clin Oral Implants Res, 2001, 12:339-349.
5. Cameron HU. Bone implant interface. St Louis: Mosby Publishing Company, 1994. 89-90.
6. Puleo DA, Nanci A. Understanding and controlling of bone implant interface. Biomaterials, 1999,20:2311-2321.
7. Sykaras N, Triplett RG, Nunn ME, et al. Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants. Clin Oral Implants Res, 2001, 12:339-349.
8. Hassan AH, Evans CA, Zaki AM, et al. Use of bone morphogenetic protein-2 and dentin matrix protein-1 to enhance the osteointegration of the Onplant system. Connect Tissue Res, 2003,44:30-41.
9. Koempel JA, Patt BS, O'Grady K, et al. The effect of recombinant human bone morphogenetic protein-2 on the integration of porous hydroxyapatite implants with bone. J Biomed Mater Res, 1998,41: 359-363.
10. Bragdon CR, Doherty AM, Rubash HE, et al. The efficacy of BMP-2 to induce bone ingrowth in a total hip replacement model. Clin Orthop, 2003,417:50-61.
11. Juren L, Xu F, Merkel K, et al. Gene therapy: adenovirus-mediated human bone morphogenetic protein gene transfer induces mesenchymal progenitor cell differentiation in vitro, bone formation in vivo. J Orthop Res, 1999,17:43-50.
12. Dee KC, Rueger DC, Andersen TT, et al. Conditions which promote mineralization at the bone implant interface: a model in vitro study. Biomaterials, 1996,17:209-215.
13. Lind M, Overgaard S, Ongpipattanakul B, et al. Transforming growth factor-b1 stimulates bone ongrowth to weight-loaded tricalcium phosphate coated implants: an experimental study in dogs. J Bone Joint Surg, 1996,78B:377-382.
14. Piattelli A, Scarano A, Corigliano M, et al. Effects of alkaline phosphatase on bone healing around plasma-sprayed titanium implants: a pilot study in rabbits. Biomaterials, 1996, 17: 1443-1449.
15. Frosch KH, Sondergeld I, Dresing K, et al. Autologous osteoblasts enhance osseointegration of porous titanium implants. J Orthop Res, 2003,21:213-223.