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Volumn 90, Issue 6, 2005, Pages 3646-3652

The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCOSE; INSULIN; LEUCINE; NEUROPEPTIDE Y; NEUROTRANSMITTER; NORADRENALIN; PROLINE; CORBADRINE; PEPTIDE HORMONE; PREPRONEUROPEPTIDE Y; PROTEIN PRECURSOR;

EID: 21244492860     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2005-0153     Document Type: Article
Times cited : (13)

References (40)
  • 1
    • 0029554361 scopus 로고
    • Neuropeptide Y. A novel sympathetic stress hormone and more
    • Zukowska-Grojec Z 1995 Neuropeptide Y. A novel sympathetic stress hormone and more. Ann NY Acad Sci 771:219-233
    • (1995) Ann NY Acad Sci , vol.771 , pp. 219-233
    • Zukowska-Grojec, Z.1
  • 3
    • 0031884714 scopus 로고    scopus 로고
    • Renal effects of neuropeptide Y
    • Bischoff A, Michel MC 1998 Renal effects of neuropeptide Y. Pflugers Arch 435:443-453
    • (1998) Pflugers Arch , vol.435 , pp. 443-453
    • Bischoff, A.1    Michel, M.C.2
  • 4
    • 0034020774 scopus 로고    scopus 로고
    • Vasodilation in human subcutaneous arteries induced by neuropeptide Y is mediated by neuropeptide Y Y1 receptors and is nitric oxide dependent
    • Nilsson T, Lind H, Brunkvall J, Edvinsson L 2000 Vasodilation in human subcutaneous arteries induced by neuropeptide Y is mediated by neuropeptide Y Y1 receptors and is nitric oxide dependent. Can J Physiol Pharmacol 78:251-255
    • (2000) Can J Physiol Pharmacol , vol.78 , pp. 251-255
    • Nilsson, T.1    Lind, H.2    Brunkvall, J.3    Edvinsson, L.4
  • 5
    • 0031761397 scopus 로고    scopus 로고
    • Neuropeptide Y lowers blood glucose in anaesthetized rats via a Y5 receptor subtype
    • Bischoff A, Michel MC 1998 Neuropeptide Y lowers blood glucose in anaesthetized rats via a Y5 receptor subtype. Endocrinology 139:3018-3021
    • (1998) Endocrinology , vol.139 , pp. 3018-3021
    • Bischoff, A.1    Michel, M.C.2
  • 6
    • 0022381442 scopus 로고
    • Neuropeptide Y: Direct and indirect action on insulin secretion in the rat
    • Moltz JH, McDonald JK 1985 Neuropeptide Y: direct and indirect action on insulin secretion in the rat. Peptides 6:1155-1159
    • (1985) Peptides , vol.6 , pp. 1155-1159
    • Moltz, J.H.1    McDonald, J.K.2
  • 7
    • 0034020605 scopus 로고    scopus 로고
    • Adrenalectomy reduces neuropeptide Y-induced insulin release and NPY receptor expression in the rat ventromedial hypothalamus
    • Wisialowski T, Parker R, Preston E, Sainsbury A, Kraegen E, Herzog H, Cooney G 2000 Adrenalectomy reduces neuropeptide Y-induced insulin release and NPY receptor expression in the rat ventromedial hypothalamus. J Clin Invest 105:1253-1259
    • (2000) J Clin Invest , vol.105 , pp. 1253-1259
    • Wisialowski, T.1    Parker, R.2    Preston, E.3    Sainsbury, A.4    Kraegen, E.5    Herzog, H.6    Cooney, G.7
  • 10
    • 20244365772 scopus 로고    scopus 로고
    • Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels
    • Karvonen MK, Pesonen U, Koulu M, Niskanen L, Laakso M, Rissanen A, Dekker JM, Hart LM, Valve R, Uusitupa MI 1998 Association of a leucine(7)-to- proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Nat Med 4:1434-1437
    • (1998) Nat Med , vol.4 , pp. 1434-1437
    • Karvonen, M.K.1    Pesonen, U.2    Koulu, M.3    Niskanen, L.4    Laakso, M.5    Rissanen, A.6    Dekker, J.M.7    Hart, L.M.8    Valve, R.9    Uusitupa, M.I.10
  • 11
    • 0345059245 scopus 로고    scopus 로고
    • Distribution of the NPY 1128C allele frequency in different populations
    • Ding B 2003 Distribution of the NPY 1128C allele frequency in different populations. J Neural Transm 110:1199-1204
    • (2003) J Neural Transm , vol.110 , pp. 1199-1204
    • Ding, B.1
  • 13
    • 0034457311 scopus 로고    scopus 로고
    • Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children
    • Karvonen MK, Koulu M, Pesonen U, Uusitupa MI, Tammi A, Viikari J, Simell O, Ronnemaa T 2000 Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children. J Clin Endocrinol Metab 85:1455- 1460
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1455-1460
    • Karvonen, M.K.1    Koulu, M.2    Pesonen, U.3    Uusitupa, M.I.4    Tammi, A.5    Viikari, J.6    Simell, O.7    Ronnemaa, T.8
  • 14
    • 17744393296 scopus 로고    scopus 로고
    • Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects
    • Niskanen L, Karvonen MK, Valve R, Koulu M, Pesonen U, Mercuri M, Rauramaa R, Toyry J, Laakso M, Uusitupa MI 2000 Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects. J Clin Endocrinol Metab 85:2266-2269
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2266-2269
    • Niskanen, L.1    Karvonen, M.K.2    Valve, R.3    Koulu, M.4    Pesonen, U.5    Mercuri, M.6    Rauramaa, R.7    Toyry, J.8    Laakso, M.9    Uusitupa, M.I.10
  • 16
    • 0842268335 scopus 로고    scopus 로고
    • Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients
    • Pettersson-Fernholm K, Karvonen MK, Kallio J, Forsblom CM, Koulu M, Pesonen U, Fagerudd JA, Groop PH, FinnDiane Study Group 2004 Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with proteinuria, coronary heart disease, and glycemic control in type 1 diabetic patients. Diabetes Care 27:503-509
    • (2004) Diabetes Care , vol.27 , pp. 503-509
    • Pettersson-Fernholm, K.1    Karvonen, M.K.2    Kallio, J.3    Forsblom, C.M.4    Koulu, M.5    Pesonen, U.6    Fagerudd, J.A.7    Groop, P.H.8
  • 17
    • 3042754862 scopus 로고    scopus 로고
    • Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population
    • Wallerstedt SM, Skrtic S, Eriksson AL, Ohlsson C, Hedner T 2004 Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population. J Hypertens 22:1277-1281
    • (2004) J Hypertens , vol.22 , pp. 1277-1281
    • Wallerstedt, S.M.1    Skrtic, S.2    Eriksson, A.L.3    Ohlsson, C.4    Hedner, T.5
  • 18
    • 0035347179 scopus 로고    scopus 로고
    • Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans
    • Kallio J, Pesonen U, Kaipio K, Karvonen MK, Jaakkola U, Heinonen OJ, Uusitupa MI, Koulu M 2001 Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans. FASEB J 15:1242-1244
    • (2001) FASEB J , vol.15 , pp. 1242-1244
    • Kallio, J.1    Pesonen, U.2    Kaipio, K.3    Karvonen, M.K.4    Jaakkola, U.5    Heinonen, O.J.6    Uusitupa, M.I.7    Koulu, M.8
  • 20
    • 0037622770 scopus 로고    scopus 로고
    • Changes in diurnal sympathoadrenal balance and pituitary hormone secretion in subjects with Leu7Pro polymorphism in the prepro-neuropeptide Y
    • Kallio J, Pesonen U, Jaakkola U, Karvonen MK, Helenius H, Koulu M 2003 Changes in diurnal sympathoadrenal balance and pituitary hormone secretion in subjects with Leu7Pro polymorphism in the prepro-neuropeptide Y. J Clin Endocrinol Metab 88:3278-3283
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3278-3283
    • Kallio, J.1    Pesonen, U.2    Jaakkola, U.3    Karvonen, M.K.4    Helenius, H.5    Koulu, M.6
  • 21
    • 0029988782 scopus 로고    scopus 로고
    • Heart rate variability. Standards of measurement, physiological interpretation, and clinical use
    • Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology
    • 1996 Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 17:354-381
    • (1996) Eur Heart J , vol.17 , pp. 354-381
  • 22
    • 0027444682 scopus 로고
    • Spontaneous baroreflex by sequence and power spectral methods in humans
    • Hughson RL, Quintin L, Annat G, Yamamoto Y, Gharib C 1993 Spontaneous baroreflex by sequence and power spectral methods in humans. Clin Physiol 13:663-676
    • (1993) Clin Physiol , vol.13 , pp. 663-676
    • Hughson, R.L.1    Quintin, L.2    Annat, G.3    Yamamoto, Y.4    Gharib, C.5
  • 23
    • 0035143816 scopus 로고    scopus 로고
    • Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
    • Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K 2001 Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50:227-232
    • (2001) Diabetes , vol.50 , pp. 227-232
    • Shintani, M.1    Ogawa, Y.2    Ebihara, K.3    Aizawa-Abe, M.4    Miyanaga, F.5    Takaya, K.6    Hayashi, T.7    Inoue, G.8    Hosoda, K.9    Kojima, M.10    Kangawa, K.11    Nakao, K.12
  • 24
    • 0037677591 scopus 로고    scopus 로고
    • Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients
    • Anderwald C, Brabant G, Bernroider E, Horn R, Brehm A, Waldhausl W, Roden M 2003 Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients. Diabetes 52:1792-1798
    • (2003) Diabetes , vol.52 , pp. 1792-1798
    • Anderwald, C.1    Brabant, G.2    Bernroider, E.3    Horn, R.4    Brehm, A.5    Waldhausl, W.6    Roden, M.7
  • 25
    • 0025760194 scopus 로고
    • Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4- hydroxyphenylglycol (MHPG) are insensitive indicators of α2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers
    • Scheinin M, Karhuvaara S, Ojala-Karlsson P, Kallio A, Koulu M 1991 Plasma 3,4-dihydroxyphenylglycol (DHPG) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are insensitive indicators of α2-adrenoceptor mediated regulation of norepinephrine release in healthy human volunteers. Life Sci 49:75-84
    • (1991) Life Sci , vol.49 , pp. 75-84
    • Scheinin, M.1    Karhuvaara, S.2    Ojala-Karlsson, P.3    Kallio, A.4    Koulu, M.5
  • 28
    • 1642578979 scopus 로고    scopus 로고
    • Neuropeptide Y promotes β-cell replication via extracellular signal-regulated kinase activation
    • Cho YR, Kim CW 2004 Neuropeptide Y promotes β-cell replication via extracellular signal-regulated kinase activation. Biochem Biophys Res Commun 314:773-780
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 773-780
    • Cho, Y.R.1    Kim, C.W.2
  • 32
    • 0036714764 scopus 로고    scopus 로고
    • Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: Responses to the intravenous and oral administration of glucose
    • Lond
    • Nakagawa E, Nagaya N, Okumura H, Enomoto M, Oya H, Ono F, Hosoda H, Kojima M, Kangawa K 2002 Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose. Clin Sci (Lond) 103:325-328
    • (2002) Clin Sci , vol.103 , pp. 325-328
    • Nakagawa, E.1    Nagaya, N.2    Okumura, H.3    Enomoto, M.4    Oya, H.5    Ono, F.6    Hosoda, H.7    Kojima, M.8    Kangawa, K.9
  • 35
    • 0345328840 scopus 로고    scopus 로고
    • Acute plasma glucose increase, but not early insulin response, regulates plasma ghrelin
    • Briatore L, Andraghetti G, Cordera R 2003 Acute plasma glucose increase, but not early insulin response, regulates plasma ghrelin. Eur J Endocrinol 149:403-406
    • (2003) Eur J Endocrinol , vol.149 , pp. 403-406
    • Briatore, L.1    Andraghetti, G.2    Cordera, R.3
  • 36
    • 0942290495 scopus 로고    scopus 로고
    • Abnormal ghrelin secretion in new onset childhood type 1 diabetes
    • Holdstock C, Ludvigsson J, Karlsson FA 2004 Abnormal ghrelin secretion in new onset childhood type 1 diabetes. Diabetologia 47:150-151
    • (2004) Diabetologia , vol.47 , pp. 150-151
    • Holdstock, C.1    Ludvigsson, J.2    Karlsson, F.A.3
  • 38
    • 0032984406 scopus 로고    scopus 로고
    • Effect of β blockade with and without sympathomimetic activity (ISA) on sympathovagal balance and baroreflex sensitivity
    • Haberthur C, Schachinger H, Langewitz W, Ritz R 1999 Effect of β blockade with and without sympathomimetic activity (ISA) on sympathovagal balance and baroreflex sensitivity. Clin Physiol 19:143-152
    • (1999) Clin Physiol , vol.19 , pp. 143-152
    • Haberthur, C.1    Schachinger, H.2    Langewitz, W.3    Ritz, R.4
  • 39
    • 2642540734 scopus 로고    scopus 로고
    • Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue
    • Tovote P, Meyer M, Beck-Sickinger AG, von Horsten S, Ove Ogren S, Spiess J, Stiedl O 2004 Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue. Regul Pept 120:205-214
    • (2004) Regul Pept , vol.120 , pp. 205-214
    • Tovote, P.1    Meyer, M.2    Beck-Sickinger, A.G.3    Von Horsten, S.4    Ove Ogren, S.5    Spiess, J.6    Stiedl, O.7
  • 40
    • 0036754504 scopus 로고    scopus 로고
    • Clinical implications of present physiological understanding of HRV components
    • Lombardi F 2002 Clinical implications of present physiological understanding of HRV components. Card Electrophysiol Rev 6:245-249
    • (2002) Card Electrophysiol Rev , vol.6 , pp. 245-249
    • Lombardi, F.1


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