Venous thrombosis in inflammatory bowel disease

European Journal of Gastroenterology and Hepatology

Volumn 17, Issue 7, 2005, Pages 697-700

  SriRajaskanthan, Rajaventhan ^a   Winter, Mark ^a   Muller, Andrew F ^a  

^a KENT AND CANTERBURY HOSPITAL   (United Kingdom)

Author keywords

Factor V leiden; Hyperhomocysteinemia; Platelet activation; Prothrombin gene mutation; Tissue factor bearing microvesicles

Indexed keywords

BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 5 LEIDEN; CD40 ANTIGEN; COBALAMIN; FOLIC ACID; HOMOCYSTEINE; PADGEM PROTEIN; PROTHROMBIN; PYRIDOXINE; SERINE PROTEINASE; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID BLOOD LEVEL; BLOOD CLOTTING; CARDIOVASCULAR RISK; DISEASE ASSOCIATION; ENTERITIS; FIBRINOLYSIS; GENE MUTATION; HUMAN; HYPERHOMOCYSTEINEMIA; METABOLIC ACTIVATION; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR; THROMBOCYTE ACTIVATION; THROMBOPHILIA; VEIN THROMBOSIS; VITAMIN SUPPLEMENTATION;

BLOOD COAGULATION DISORDERS; COLITIS, ULCERATIVE; CROHN DISEASE; FACTOR V; HOMOCYSTEINE; HUMANS; INFLAMMATORY BOWEL DISEASES; MUTATION; PROTHROMBIN; RISK FACTORS; VENOUS THROMBOSIS;

EID: 21244482112     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200507000-00001     Document Type: Review

References (47)

1. Bernstein CN, Blanchard JF, Houston D, Wajda A. The incidence of venous thromboembolic disease among patients with IBD: a population-based study. Thromb Haemost 2001; 85:430-434.
2. Talbot RW, Heppell J, Dozois RR, Beart RW Jr. Vascular complications of inflammatory bowel disease. Mayo Clin Proc 1986; 61:149-145.
3. Miehsler W, Reinisch W, Valic E, Osterode W, Tillinger W, Feichtenschlager T, et al. Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut 2004; 53:542-548.
4. Jackson LM, O'Gorman PJ, O'Connell J, Cronin CC, Cotter KP, Shanahan F. Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. QJ Med 1997; 90:183-188.
5. Novacek G, Miehsler W, Kapiotis S, Katzenschlager R, Speiser W, Vogelsang H. Thromboembolism and resistance to activated protein C in patients with inflammatory bowel disease. Am J Gastroenterol 1998; 115:830-834.
6. Graef V, Baggenstoss AH, Seaur WG. Venous thrombosis occurring in non-specific ulcerative colitis. Arch Intern Med 1966; 117:377-382.
7. Thong BYH, Chng HH, Ang CL, Ho MS. Recurrent venous thromboses, anticardiolipin antibodies and Crohn's disease. QJ Med 2002; 95:253-257.
8. Hatoum OA, Spinelli KS, Abu-Hajir M, Attila T, Franco J, Otterson MF, et al. Mesenteric venous thrombosis in inflammatory bowel disease. J Clin Gastrol 2005; 39:27-31.
9. Wong T, Nightingale M, Winter M, Muller AF. Spontaneous venous thrombosis in inflammatory bowel disease: relevance of factor V Leiden and the prothrombin gene mutation. J Thromb Haemost 2003; 1: 1326-1328.
10. Virchow RLK. Thrombosis and Embolisms [in German; translated by Matzdorff et al.]. Canton, MA: Science History Publications; 1998.
11. Koutroubakis EI. Unravelling the mechanisms of thrombosis in inflammatory bowel disease. Am J Gastroenterol 2001; 91:1325-1327.
12. Dhillon A, Anthony A, Sim R, Wakefield AJ, Sankey E, Hudson M. Mucosal capillary thrombi in rectal biopsies. Histopathoiogy 1992; 21: 127-133.
13. Wakefield AJ, Sawyerr AM, Dhillon AP, Pittilo RM, Rowles PM, Lewis AAM, et al. Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet 1989; ii:1057-1062.
14. Thompson NP, Wakefield AJ, Pounder RE. Inherited disorders of coagulation appear to protect against inflammatory bowel disease. Gastroenterohgy 1995; 108:1011-1015.
15. Gaffney P, Doyle C, Gaffney A, Hogan J, Hayes D, Annis P. Paradoxical response to heparin in 10 patients with ulcerative colitis. Am J Gastroenterol 1995; 90:220-223.
16. Folwaczny C, Wiebecke B, Loeschke K. Unfractionated heparin in the therapy of patients with highly active inflammatory bowel disease. Am J Gastroenterol 1999; 94:1551-1555.
17. Torkvist L, Thorlacius H, Sjoqvist U, Bohman L, Lapidus A, Flood L, et al. Low molecular weight heparin as adjuvant therapy in active ulcerative colitis. Aliment Pharmacol Ther 1999; 13:1323-1328.
18. Chiarantini E, Valanzano R, Liotta AA, Cellai AP, Fedi S, Ilari I, et al. Hemostatic abnormalities in inflammatory bowel disease. Thromb Res 1996; 82:137-146.
19. Novacek G, Kapiotis S, Moser G, Speiser W, Gangl A, Volgelsang H. No evidence of activated blood coagulation in Crohn's disease. Eur J Gastroenterol Hepatol 1997; 9:963-967.
20. De Jong E, Porte RJ, Knot EAR, Verheijen JH, Dees J. Disturbed fibrinolysis in patients with inflammatory bowel disease. A study in blood plasma, colon mucosa, and faeces. Gut 1989; 30:188-194.
21. van Bodegraven AA, Schoorl M, Linskens RK, Bartels PC, Tuynman HA. Persistent activation of coagulation and fibrinolysis after treatment of active ulcerative colitis. Eur J Gastroenterol Hepatol 2002; 14:413-418.
22. Fernando M, Dinis-Ribeiro M, Fernando A, Pereira P, Fraga M, Luis M, et al. High prevalence of combined thrombophilic abnormalities in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol 2003; 15: 1157-1163.
23. Kujovich J. Thrombophilia and thrombotic problems in renal transplant patients. Transplantation 2004; 77:959-964.
24. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 86:4700-4702.
25. Over HH, Ulgen S, Tuglular T, Tezel A, Avasar E, Geyik G, et al. Thrombophilia and inflammatory bowel disease: does factor V mutation have a role? Eur J Gastroenterol Hepatol 1998; 10:827-829.
26. Kader HA, Berman WF, Amal AS, Ware RE, Ulshen MH, Treem WR. Prevalence of factor V Leiden, prothrombin G20210A, and methylee tetrahydrofolate reductase C677T thrombophilic mutations in children with inflammatory bowel disease. J Paediatr Gastroenterol Nutr 2002; 35: 629-635.
27. Papa A, Stefano V, Gasbarrini A, Chiusolo P, Cianci R, Casorelli I, et al. Prevalence of factor V Leiden and the G20210A prothrombin-gene mutation in inflammatory bowel disease. Blood Coagul Fibrinolysis 2000; 11: 499-503.
28. Liebman HA, Kashani N, Sutherland D, McGehee W, Kam AL. The factor V Leiden mutation increases the risk of venous thrombosis in patients with inflammatory bowel disease. Gastroenterology 1998; 115: 830-834.
29. Haslam N, Standen GR, Probert CS. An investigation of the association of the factor V Leiden mutation and inflammatory bowel disease. Eur J Gastroenterol Hepatol 1999; 11:1289-1291.
30. Salomon O, Steinberg DM, Zivenin A, Gitel S, Dardik R, Rosenberg N, et al. Single and combined prothrombotic factors In patients with idiopathic venous thromboembolism: prevalence and risk assessment. Arterioscler Thromb Vasc Biol 1999; 19:511-518.
31. De Stefano V, Martinelli I, Mannucci PM, Paciaroni K, Chiusolo P, Casorelli I, et al. The risk of recurrent venous thromboembolism among heterozygous carriers of both factor V Leiden and the G20210A prothrombin gene mutation. N Engl J Med 1999; 341:801-806.
32. Haslam N, Standen GR, Probert CS. An investigation of the association of the prothrombin G20210A gene mutation and inflammatory bowel disease: factor II and IBD. Inflamm Bowel Dis 2001; 7:133-135.
33. den Heijer M, Koster T, Blom HJ, Bos GM, Briet E, Reitsma PH, et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 334:759-762.
34. Ridker PM, Hennekens CH, Selhub J, Miletich JR Malinow MR, Stampfer MJ, et al. Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation 1997; 95: 1777-1782.
35. Morgenstern I, Raimakers MTM, Peters WHM, Kirch W. Homocysteine, cysteine and glutathione in human colonic mucosa: elevated levels of homocysteine in patients with inflammatory bowel disease. Dig Dis Sci 2003; 48:2083-2090.
36. Oldenburg B, Fijnheer R, van der Griend R, vanBerge-Henegouwen GP, Koningsberger JC. Homocysteine in inflammatory bowel disease: a risk factor for thromboembolic complications? Am J Gastroenterol 2000; 95:2825-2830.
37. Vasilopoulos S, Saiean K, Emmond J, Berger WL, Abu-Hajir M, Seetharam B, et al. Terminal ileum resection is associated with higher plasma homocysteine levels in Crohn's disease. J Clin Gastroenterol 2001; 96:2143-2149.
38. Cattaneo M, Vecchi M, Saibeni S, Martielli I, Mannucci PM, de Franchis R. High prevalence of hyperhomocysteinemia in patients with inflammatory bowel disease: a pathogenic link with thromboembolic complications? Thromb Haemost 1998; 80:542-545.
39. Bos GMJ, den Heijer M, Willems H, Blom H, Gerrits W, Cattaneo M, et al. Homocysteine lowering by B vitamins and the secondary prevention of deep-vein thrombosis and pulmonary embolism. A first randomized, placebo controlled trial. Blood 2004; 104:A489.
40. Collins CE, Rampton DS. Platelets in inflammatory bowel disease - pathogenetic role and therapeutic implications. Aliment Pharmacol Ther 1997; 11:237-247.
41. Fiocchi C. Intestinal inflammation: a complex interplay of immune and non-immune Interactions. Am J Physiol 1997; 273:769-775.
42. Andre P, Nannizzi-Alaimo L, Prasad SK, Philips DR. Platelet derived CD40L: the switch hitting player of cardiovascular disease. Circulation 2002; 106:896-899.
43. Danese S, Katz A, Saibeni S, Papa A, Vecchi M, Fiocchi C. Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients. Gut 2003; 52: 1435-1441.
44. Vakkalanka RK, Woo C, Kirou KA, Koshy M, Berger D, Crow MK. Elevated levels and functional capacity of soluble CD40 ligand in systemic lupus erythematous sera. Arthritis Rheum 1999; 42:871-881.
45. López JA, Kearon C, Lee AYY. Deep vein thrombosis. Hematology (Am Soc Hematol Educ Program) 2004; 439-456.
46. Myers DD, Hawley AE, Farris DM, Worbleski SK, Thanaporn P, Schaub RG, et al. P-selectin and leukocyte micropartlcles are associated with venous thrombogenesis. J Vasc Surg 2003; 38:1075-1089.
47. Falati S, Liu Q, Gross P, Merrill-Skoloff G, Chou J, Vandendries E, et al. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med 2003; 197:1585-1598.