A case of Aspergillus mediastinitis after heart transplantation successfully treated with liposomal amphotericin B, caspofungin and voriconazole

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 24, Issue 5, 2005, Pages 347-349

  Forestier, E ^a   Remy, V ^a   Lesens, O ^a   Martinot, M ^b   Hansman, Y ^a   Eisenmann, B ^a   Christmann, D ^a  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b Pasteur Hospital   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; AMPHOTERICIN B LIPID COMPLEX; BILIRUBIN; C REACTIVE PROTEIN; CASPOFUNGIN; CYCLOSPORIN; GAMMA GLUTAMYLTRANSFERASE; IMIPENEM; ITRACONAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; VANCOMYCIN; VORICONAZOLE;

ABSCESS DRAINAGE; ADULT; ANTIBIOTIC THERAPY; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CASE REPORT; CHOLESTASIS; COMPUTER ASSISTED TOMOGRAPHY; CURETTAGE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; FEVER; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MEDIASTINITIS; MINIMUM INHIBITORY CONCENTRATION; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; REVIEW; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS INFECTION; THERAPY RESISTANCE; THORAX PAIN; TREATMENT OUTCOME; WOUND CLOSURE; WOUND DRAINAGE;

AMPHOTERICIN B; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; FEMALE; HEART TRANSPLANTATION; HUMANS; MEDIASTINITIS; MIDDLE AGED; PEPTIDES, CYCLIC; PYRIMIDINES; SURGICAL WOUND INFECTION; TRIAZOLES;

EID: 21244465821     PISSN: 09349723     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10096-005-1327-5     Document Type: Review

References (18)

1. King RC, Barnes AD (2003) Mediastinitis after cardiac surgery. Curr Treat Opt Inf Dis 5:377-386
2. Karwande SV, Renlund DG, Olsen SL, Gay WA Jr, Richenbacher WE, Hawkins JA, Millar RC, Marks JD (1992) Mediastinitis in heart transplantation. Ann Thorac Surg 54:1039-1045
3. Stolf NA, Fiorelli AI, Bacal F, Camargo LF, Bocchi EA, Freitas A, Nicoletti A, Meira D (2000) Mediastinitis after cardiac transplantation. Arq Bras Cardiol 74:419-430
4. Hofflin JM, Potasman I, Baldwin JC, Oyer PE, Stinson EP, Remington JS (1987) Infectious complications in heart transplant recipient receiving cyclosporine and corticosteroids. Ann Intern Med 106:209-216
5. Gentry LO, Zeluff BJ (1988) Nosocomial and other difficult infections in the immunocompromised cardiac transplant patient. J Hosp Infect 11(Suppl A):21-28
6. Cohen DM, Goggans EA (1971) Sclerosing mediastinitis and terminal valvular endocarditis caused by fungus suggestive of Aspergillus species. Am J Clin Pathol 56:91-96
7. Ahmad M, Weinstein AJ, Hughes JA, Cosgrove DE (1981) Granulomatous mediastinitis due to Aspergillus flavus in a non immunosuppressed patient. Am J Med 70:887-890
8. Byl B, Jacobs F, Antoine M, Depierreux M, Serruys E, Primo G, Thys JP (1993) Mediastinitis caused by Aspergillus fumigatus with ruptured aortic pseudoaneurysm in a heart transplant recipient: case study. Heart Lung 22:145-147
9. Kujath P, Klempien I, Muhl E, Kammerer R (2000) Invasive aspergillosis on a surgical intensive care unit. Mycoses 43(Suppl 2):23-27
10. Verghese S, Methew T, Padmaja P, Mullasari A, Sivaraman A, Kurien VM (2001) Sclerosing mediastinitis caused by Aspergillus terreus. Ind J Pathol Microbiol 44:141-143
11. Vandecasteele SJ, Boelaert JR, Verrelst P, Graulus E, Gordts BZ (2002) Diagnosis and treatment of Aspergillus flavus sternal wound infections after cardiac surgery. Clin Infect Dis 35:887-890
12. Atassi G, Al-Shamy A (2002) Invasive aspergillosis of the neck and upper mediastinum with intraspinal extension: an unsual presentation. Ann Saudi Med 22:84-85
13. Lutz BD, Jin J, Rinaldi MG, Wickes BL, Huycke MM (2003) Outbreak of invasive Aspergillus infection in surgical patients, associated with a contaminated air-handling system. Clin Infect Dis 37:786-793
14. Garner JS, Jarvis WR, Emori TG, Hughes JM (1988) CDC definitions for nosocomial infections 1988. Am J Infect Control 16:128-140
15. Ascioglu S, Rex JH, de Pauw B (2002) Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34:7-14
16. Arikan S, Lozano-Chiu M, Paetznick V, Rex JH (2002) In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp. Antimicrob Agents Chemother 46:245-247
17. Aliff TB, Maslak PG, Jurcic JG, Heaney ML, Cathcart KN, Sepkowi Weiss MA (2003) Refractory Aspergillus pneumonia in patients with acute leukaemia: successful therapy with combination caspofungin and liposomal amphotericin. Cancer 97:1025-1032
18. Rubin MA, Carroll KC, Cahill BC (2002) Caspofungin in combination with itraconazole for the treatment of invasive aspergillosis in humans. Clin Infect Dis 34:1160-1161