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Volumn 9, Issue 3, 2005, Pages 427-429

Paradigm shift in NMDA receptor drug development

Author keywords

Antagonist; Memantine; NMDA receptor

Indexed keywords

ADAMANTANE DERIVATIVE; CALCIUM CHANNEL; CALCIUM ION; CHOLINESTERASE INHIBITOR; DIZOCILPINE; GLUTAMIC ACID; GLYCINE; KETAMINE; MAGNESIUM ION; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; PHENCYCLIDINE; SODIUM ION;

EID: 21244458852     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.9.3.427     Document Type: Editorial
Times cited : (10)

References (6)
  • 1
    • 0026564448 scopus 로고
    • Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicity
    • CHEN H-S V, PELLEGRINI JW, AGGARWAL SK et al.; Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci. (1992) 12:4427-4436.
    • (1992) J. Neurosci. , vol.12 , pp. 4427-4436
    • Chen, H.-S.V.1    Pellegrini, J.W.2    Aggarwal, S.K.3
  • 2
    • 0027508237 scopus 로고
    • Prospects for clinically tolerated NMDA antagonists: Open-channel blockers and alternative redox states of nitric oxide
    • LIPTON SA: Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide. Trends Neurosci. (1993) 16:527-532.
    • (1993) Trends Neurosci. , vol.16 , pp. 527-532
    • Lipton, S.A.1
  • 3
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • LIPTON SA, ROSENBERG PA: Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. (1994) 330:613-622.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 4
    • 0031034905 scopus 로고    scopus 로고
    • Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: Uncompetitive antagonism
    • CHEN H-S V, LIPTON SA: Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J. Physiol. (Lond.) (1997) 499:27-46.
    • (1997) J. Physiol. (Lond.) , vol.499 , pp. 27-46
    • Chen, H.-S.V.1    Lipton, S.A.2
  • 5
    • 0032543788 scopus 로고    scopus 로고
    • Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation
    • CHEN H-S V, WANG YF, RAYUDU PV et al.: Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience (1998) 86:1121-1132.
    • (1998) Neuroscience , vol.86 , pp. 1121-1132
    • Chen, H.-S.V.1    Wang, Y.F.2    Rayudu, P.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.