A randomized, controlled trial of a new vascular catheter flush solution (minocycline-EDTA) in temporary hemodialysis access

Infection Control and Hospital Epidemiology

Volumn 26, Issue 6, 2005, Pages 520-524

  Bleyer, Anthony J ^a   Mason, Lori ^a   Russell, Gregory ^a   Raad, Issam I ^b   Sherertz, Robert J ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EDETIC ACID; HEPARIN; MINOCYCLINE;

ADULT; ARTICLE; BACTEREMIA; BACTERIAL COLONIZATION; BLOOD CULTURE; CATHETER INFECTION; CLINICAL PROTOCOL; CLINICAL TRIAL; COLONY FORMING UNIT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIALYSIS; DOUBLE BLIND PROCEDURE; ENTEROBACTER AEROGENES; FEMALE; HEMODIALYSIS; HUMAN; INFECTION CONTROL; INFECTION RISK; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; SURVIVAL; THROMBOSIS; VASCULAR ACCESS;

ANTI-BACTERIAL AGENTS; ANTICOAGULANTS; CATHETERIZATION, CENTRAL VENOUS; CATHETERS, INDWELLING; CROSS INFECTION; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; EDETIC ACID; EQUIPMENT CONTAMINATION; FEMALE; HEPARIN; HUMANS; INFECTION CONTROL; IRRIGATION; MALE; MIDDLE AGED; MINOCYCLINE; NORTH CAROLINA; PILOT PROJECTS; PROSPECTIVE STUDIES; RENAL DIALYSIS; RISK FACTORS; SEPSIS; SURVIVAL ANALYSIS; THROMBOSIS; TIME FACTORS;

EID: 21244457258     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/502578     Document Type: Article

References (16)

1. Hoen B, Kessler M, Hestin D, Mayeux D. Risk factors for bacterial infections in chronic haemodialysis adult patients: a multicentre prospective survey. Nephrol Dial Transplant 1995;10:377-381.
2. Hoen B, Paul-Dauphin A, Hestin D, Kessler M. EPIBACDIAL: a multicenter prospective study of risk factors for bacteremia in chronic hemodialysis patients. J Am Soc Nephrol 1998;9:869-876.
3. Taylor GD, McKenzie M, Buchanan-Chell M, Caballo L, Chui L, Kowalewska-Grochowska K. Central venous catheters as a source of hemodialysis-related bacteremia. Infect Control Hosp Epidemiol 1998;19:643-646.
4. Stevenson KB, Adcox MJ, Mallea MC, Narasimhan N, Wagnild JP. Standardized surveillance of hemodialysis vascular access infections: 18-month experience at an outpatient, multifacility hemodialysis center. Infect Control Hosp Epidemiol 2000;21:200-203.
5. Tokars JI, Light P, Anderson J, et al. A prospective study of vascular access infections at seven outpatient hemodialysis centers. Am J Kid Dis 2001;37:1232-1240.
6. Beathard GA. Catheter thrombosis. Semin Dial 2001;14:441-445.
7. Sherertz RJ. Pathogenesis of vascular catheter infections. In: Seifert H, Jansen B, Farr BM, eds. Catheter-Related Infections. New York: Marcel Dekker; 1997:1-29.
8. Raad I, Buzaid A, Rhyne J, et al. Minocycline and EDTA for the prevention of recurrent vascular catheter infections. Clin Infect Dis 1997;25:149-151.
9. Chatzinikolaou I, Zipf TF, Hanna H, et al. Minocycline- ethylenediaminetetraacetate lock solution for the prevention of implantable port infections in children with cancer. Clin Infect Dis 2003;36:116-119.
10. Dogra GK, Herson H, Hutchison B, et al. Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: a randomized controlled study. J Am Soc Nephrol 2002;13:2133-2139.
11. Allon M. Prophylaxis against dialysis catheter-related bacteremia with a novel antimicrobial solution. Clin Infect Dis 2003;36:1539-1544.
12. Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identification of catheter-related infection. N Engl J Med 1997;296: 1305-1309.
13. Sherertz RJ, Heard SO, Raad II. Diagnosis of triple-lumen catheter infection: comparison of roll plate, sonication, and flushing methodologies. J Clin Microbiol 1997;35:641-646.
14. Sherertz RJ, Raad II, Belani A, et al. Three-year experience with sonicated vascular catheter cultures in a clinical microbiology laboratory. J Clin Microbiol 1990;28:76-82.
15. Capdevila JA, Planes AM, Palomar M, et al. Value of differential quantitative blood cultures in the diagnosis of catheter-related sepsis. Eur J Clin Microbiol Infect Dis 1992;11:403-407.
16. Rijinders BJA, Van Wijngaerden E, Peetermans WE. Catheter-tip colonization as a surrogate end point in clinical studies on catheter-related bloodstream infection: how strong is the evidence? Clin Infect Dis 2002;35:1053-1058.