Neoadjuvant therapy for rectal cancer: Improved tumor response, local recurrence, and overall survival in nonanemic patients

Diseases of the Colon and Rectum

Volumn 48, Issue 6, 2005, Pages 1153-1160

  Box, Ben ^a   Lindsey, Ian ^a,b   Wheeler, James M ^a   Warren, Bryan F ^a   Cunningham, Chris ^a   George, Bruce D ^a   Mortensen, Neil J ^a   Jones, Adrian C ^a  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Chemoradiotherapy; Local recurrence; Rectal cancer

Indexed keywords

FLUOROURACIL; HEMOGLOBIN;

ADJUVANT THERAPY; ADULT; AGED; ANEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; ONCOLOGY; RECTUM CANCER;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANEMIA; COHORT STUDIES; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 21244454927     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10350-004-0939-7     Document Type: Article

References (17)

1. T Buroker N Nigro J Correa VK Vaitkevicius M Samson B Considine 1976 Combination preoperative radiation and chemotherapy in adenocarcinoma of the rectum Dis Colon Rectum 19 660 3
2. BD Minsky AM Cohen N Kemeny 1994 Efficacy of preoperative 5-FU, high dose leucovorin, and sequential radiation therapy for unresectable rectal cancer Cancer 73 273 80
3. J Garcia-Aguilar E Hernandez de Anda P Sirivongs S-H Lee RD Madoff DA Rothenberger 2003 A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision Dis Colon Rectum 46 298 304
4. JM Wheeler BF Warren NJ Mortensen 2002 Quantification of histologic regression of rectal cancer after irradiation: a proposal for a modified staging system Dis Colon Rectum 45 1051 6
5. JM Wheeler BF Warren 2004 Preoperative chemoradiotherapy and total mesorectal excision surgery for locally advanced rectal cancer: correlation with rectal cancer regression grade Dis Colon Rectum 47 2025 31
6. P Luna-Pérez J Segura I Alvarado S Labastida H Santiago-Payán A Quintero 2000 Specific c-K-ras gene mutations as a tumor-response marker in locally advanced rectal cancer treated with preoperative chemoradiotherapy Ann Surg Oncol 7 727 31
7. A Grann P Zauber 2002 Is there a predictive value for molecular markers in predicting response to radiation and chemotherapy in rectal cancer? Int J Radiat Oncol Biol Phys 54 1286 7
8. P Vaupel O Thews M Hoeckel 2001 Treatment resistance of solid tumours: role of hypoxia and anaemia Med Oncol 18 243 59
9. JC Evans P Begsjö 1965 The influence of anaemia on the results of radiotherapy in carcinoma of the cervix Radiology 84 709 17
10. TJ Littlewood 2001 The impact of hemoglobin levels on treatment outcomes in patients with cancer Semin Oncol 28(Suppl 8) 49 53
11. G Thomas 2001 The effect of hemoglobin level on radiotherapy outcomes: The Canadian Experience Semin Oncol 28(Suppl 8) 60 5
12. H Frommhold R Guttenberger M Henke 1998 The impact of blood hemoglobin content on the outcome of radiotherapy. The Freiberg experience Strahlenther Onkol 174(Suppl 4) 31 4
13. G Hutchinson AG Renehan E Levine R James ST O'Dwyer 2002 Impact of hemoglobin level on treatment response in patients with anal carcinoma Colorectal Dis 4(Suppl 1) 1
14. JH Donohue S Williams S Cha 1995 Perioperative blood transfusions do not affect disease recurrence in patients undergoing curative resection of colorectal carcinoma: a Mayo/North Central Cancer Treatment Group study J Clin Oncol 13 1671 8
15. EA Levine C Laborde E Hambrick C McKnight S Vijayakumar 1998 Influence of erythropoietin on transfusion requirement in patients receiving preoperative chemoradiotherapy for rectal cancer Dis Colon Rectum 8 1065 71
16. B Leyland-Jones 2003 Breast cancer trial with erythropoietin terminated unexpectedly Lancet Oncol 4 459 60
17. M Henke R Laszig C Rube 2003 Erythropoitin to treat head and neck cancer patients with anemia undergoing radiotherapy: randomised, double-blind placebo-controlled trial Lancet 362 1255 60