Age-associated increase in creatine kinase-MB-specific activity in human serum confounds its use as an injury marker

Heart Lung and Circulation

Volumn 14, Issue 2, 2005, Pages 104-106

  Zhang, Wei Zheng ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Biochemical marker; CKMB; Enzyme and age; Specific activity

Indexed keywords

CREATINE KINASE MB; TROPONIN;

ADULT; AGE; AGED; ANALYTICAL ERROR; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CIRCULATION; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE MARKER; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME RELEASE; ENZYME SPECIFICITY; FEMALE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN MODIFICATION; RETROSPECTIVE STUDY; SEX DIFFERENCE;

EID: 21244441000     PISSN: 14439506     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hlc.2005.01.006     Document Type: Article

References (11)

1. Mair J, Morandell D, Genser N, Lechleitner P, Dienstl F, Puschendorf B. Equivalent early sensitivities of myoglobin, creatine kinase MB mass, creatine kinase isoform ratios, and cardiac troponins I and T for acute myocardial infarction. Clin Chem 1995; 41:1266-72.
2. Malasky BR, Alpert JS. Diagnosis of myocardial injury by biochemical markers: problems and promises. Cardiol Rev 2002; 10:306-17.
3. Lee TH, Rouan GW, Weisberg MC, Brand DA, Cook EF, Acampora D, et al. Sensitivity of routine clinical criteria for diagnosing myocardial infarction within 24 h of hospitalization. Ann Intern Med 1987; 106:181-6.
4. Lee KN, Csako G, Bernhardt P, Elin RJ. Relevance of macro creatine kinase type 1 and type 2 isoenzymes to laboratory and clinical data. Clin Chem 1994;40:1278-83.
5. Tozawa T. Enzyme-linked immunoglobulins and their clinical significance. Electrophoresis 1989;10:640-4.
6. Welsh TM, Kukes GD, Sandweisis LM. Differences of creatine kinase MB and cardiac troponin I concentrations in normal and diseased human myocardium. Ann Clin Lab Sci 2002;32(1):44-9.
7. Henderson AR. Chemistry with confidence: should clinical chemistry require confidence intervals for analytical and other data? Clin Chem 1993;39:929-35.
8. Chastain SL, Ketchum CH, Grizzle WE. Stability and electrophoretic characteristics of creatine kinase BB extracted from human brain and intestine. Clin Chem 1988;34:489-92.
9. Wevers RA, Olthuis HP, Van Niel JC, Van Wilgenburg MG, Soons JB. A study on the dimeric structure of creatine kinase [EC 2.7.3.2]. Clin Chim Acta 1977;75:377-85.
10. Perryman MB, Knell JD, Roberts R. Carboxypeptidase-catalyzed hydrolysis of C-terminal lysine: mechanism for in vivo production of multiple forms of creatine kinase in plasma. Clin Chem 1984; 30:662-4.
11. Schatteman KA, Goossens FJ, Scharpe SS, Neels HM, Hendriks DF. Assay of procarboxypeptidase U, a novel determinant of the fibrinolytic cascade, in human plasma. Clin Chem 1999; 45:807-13.