The use of psychotropics and survival in demented elderly individuals

International Clinical Psychopharmacology

Volumn 20, Issue 4, 2005, Pages 227-231

  Hartikainen, Sirpa ^a,b   Rahkonen, Terhi ^a,c   Kautiainen, Hannu ^d   Sulkava, Raimo ^a,d  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b Municipal Hospitals of Kuopio   (Finland)

^c Jämsä District Municipal Federation of Health Care ^*  (Finland)

^d Rheumatism Foundation   (Finland)

Author keywords

Antipsychotics; Dementia; Elderly; Psychotropics; Survival

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; CHOLINESTERASE INHIBITOR; HALOPERIDOL; HYPNOTIC SEDATIVE AGENT; LEVOMEPROMAZINE; MELPERONE; MIANSERIN; MIRTAZAPINE; NEUROLEPTIC AGENT; PERICIAZINE; PSYCHOTROPIC AGENT; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

AGE; AGED; ALZHEIMER DISEASE; ARTICLE; COGNITION; DEMENTIA; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG USE; FEMALE; HUMAN; LEWY BODY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIINFARCT DEMENTIA; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; RISK FACTOR; SEX DIFFERENCE; SURVIVAL;

AGE FACTORS; AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; DEMENTIA; FEMALE; HUMANS; MALE; PROGNOSIS; PSYCHOTROPIC DRUGS; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

EID: 21244440679     PISSN: 02681315     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004850-200507000-00006     Document Type: Article

References (31)

1. American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd rev. edn. Washington, DC: American Psychiatric Association.
2. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington, DC: American Psychiatric Association.
3. Aupperle PM, Koumaras B, Chen M, Rabinowicz A, Mirski D (2004). Long-term effects of rivastigmine treatment on neuropsychiatric and behavioral disturbances in nursing home residents with moderate to severe Alzheimer's disease: results of 52-week open label study. Curr Med Res Opin 20:1605-1612.
4. Avella J, Wetli C, Wilson J, Katz M, Hahn T (2004). Fatal olanzapine induced hyperglycemic ketoacidosis. Am J Forens Med Pathol 25:172-175.
5. Bronskill SE, Anderson GM, Sykora K, Wodchis WP, Gill S, Shulman KI, Rochon PA (2004). Neuroleptic drug therapy in older adults newly admitted to nursing homes: insidence, dose, and specialist contact. J Am Ger Soc 52: 749-755.
6. Bueno-Cavanillas A, Padilla-Ruiz F, Jimenez-Moleon JJ, Peinado-Alonso CA, Galvez-Vargas R (2000). Risk factors in falls among the elderly according to extrinsic and intrinsic precipitating causes. Eur J Epidemiol 16:849-859.
7. Erkinjuntti T, Roman G, Gauthier S, Feldman H, Rockwood K (2004). Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke 35:1010-1017.
8. Folstein MF, Folstein SE, McHugh PR (1975). 'Mini-Mental State'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
9. Frassati D, Tabib A, Lachaux B, Giloux N, Dalery J, Vittori F, et al. (2004). Hidden cardiac lesions and psychotropic drugs as a possible cause of sudden death in psychiatric patients: a report of 14 cases and a review of the literature. Can J Psychiatry 49:100-105.
10. Giron MS, Wang H-X, Bernsten C, Thorslund M, Winblad B, Fastbom J (2001). The appropriateness of drug use in an older nondemented and demented population. J Am Ger Soc 49:277-283.
11. Glassman AH, Bigger JT Jr (2001). Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am J Psychiatry 158:1774-1782.
12. Gray S, LaCroix A, Blough D, Wagner EH, Koepsell TD, Buchner D, et al. (2002). Is the use of benzodiazepines associated with incident disability? J Am Geriatr Soc 50:1012-1018.
13. Hartikainen S, Rahkonen T, Kautiainen H, Sulkava R (2003). Use of psychotropics among home-dwelling nondemented and demented elderly. Int J Geriatr Psychiatry 33:496-499.
14. Leipzig RM, Cumming RG, Tinetti M (1999). Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 47:30-39.
15. Linjakumpu T, Hartikainen S, Klaukka T, Koponen HJ, Hakko HH, Viilo KM, et al. (2004). Sedative drug use in the home-dwelling elderly. Ann Pharmacother 38:2017-2022.
16. Lopez OL, Wisniewski SR, Becker JT, Boller F, DeKosky ST (1999). Psychiatric medication and abnormal behaviour as a predictor of prognosis in probable Alzheimer disease. Arch Neurol 56:1266-1272.
17. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, et al. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of consortium on DLB international workshop. Neurology 47:1113-1124.
18. McKeith I, Del Ser T, Spano P, Emre M, Wesnes K, Anand R, et al. (2000). Efficacy of rivastigmine in dementia with Lewy bodies: results of randomized, double-blind placebo-controlled international study. Lancet 356:2031-2036.
19. Mehtonen O, Aranko K, Malkonen L, Vapaatalo H (1991). A survey of sudden death associated with the use of antipsychotic or antidepressant drugs: 49 cases in Finland. Acta Psychiatr Scand 84:58-64.
20. Mulsant B, Pollock B, Kirschner M, Shen C, Dodge H, Ganguli M (2003). Serum anticholinergic activity in a community-based sample of older adults. Relationship with cognitive performance. Arch Gen Psychiatry 60:198-203.
21. National Agency for Medicines (1999). Classification of Medicines (ATC) and Defined Daily Doses (DDD). Helsinki: NAM.
22. Parkin L, Skegg DC, Herbidson GP, Paul C (2003). Psychotropic drugs and fatal pulmoembolism. Pharmacoepidemiol Drug Safety 12:647-652.
23. Rahkonen T, Eloniemi-Sulkava U, Rissanen S, Vatanen A, Viramo P, Sulkava R (2003). Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older. J Neurol Neurosrg Psychiatry 74:720-724.
24. Ray WA, Merdith S, Thapa P, Meador KG, Hall K, Murray KT (2001). Antipsychotics and the Risk of Sudden Death. Arch Gen Psychiatry 58: 1161-1167.
25. Ried LD, Johnson RE, Gettman DA (1998). Benzodiazepine exposure and functional status in older people. J Am Ger Soc 46:1037-1039.
26. Ruth S, Straand J, Nygaard H, Bjorvatn B, Pallesen S (2004). Effect of antipsychotic withdrawal on behavior and sleep/wake activity in nursing home residents with dementia: a randomized, placebo-controlled, double-blinded study. The Bergen District Nursing Home Study. J Am Geriatr Soc 52: 1737-1743.
27. Smith D, Beier M (2004). Association between resperidone and cerebrovascular adverse event. JAMA 5:129-130.
28. Thapa PB, Gideon P, Fought RL, Ray WA (1995). Psychotropic drugs and risk of recurrent falls in ambulatory nursing home residents. Am J Epidemiol 142:202-211.
29. Thomas S (1994). Drugs, QT interval abnormalities and ventricular arrytmias. Adverse Drug Reac Toxicol Rev 13:77-102.
30. Wills P, Claesson CB, Fratiglioni L, Fastbom J, Thorslund M, Winblad B (1997). Drug use by demented and non-demented elderly people. Age Ageing 26:383-391.
31. Wooltorton E (2004). Health and drug alerts olanzapine (Zyprexa): increased incidence of cerebrovascular events in dementia trials. Can Med Assoc J 170:1395.