Hyperhomocysteinemia and MTHFR C677T and A1298C polymorphisms are associated with chronic allograft nephropathy in renal transplant recipients

Transplantation Proceedings

Volumn 36, Issue 10, 2004, Pages 2979-2981

  Pavarino Bertelli, E C ^a   Sanches De Alvarenga, M P ^a   Goloni Bertollo, E M ^a   Baptista, M A S F ^b,c   Haddad, R ^d   Hoerh, N F ^e   Eberlin, M N ^d   Abbud Filho, Mario ^b,c,e  

^a Medical School

^b CINTRANS   (Brazil)

^c Institute of Urology and Nephrology   (Brazil)

^d UNIVERSITY OF CAMPINAS   (Brazil)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; DNA; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ARTICLE; CHRONIC ALLOGRAFT NEPHROPATHY; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; KIDNEY GRAFT; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; TANDEM MASS SPECTROMETRY; VASCULAR DISEASE; BLOOD; CROSS-SECTIONAL STUDY; GENE FREQUENCY; GENETICS; ISOLATION AND PURIFICATION; KIDNEY TRANSPLANTATION; PATHOLOGY; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT FAILURE;

CROSS-SECTIONAL STUDIES; DNA; GENE FREQUENCY; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; KIDNEY TRANSPLANTATION; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; RISK FACTORS; TREATMENT FAILURE;

EID: 21244437616     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2004.12.002     Document Type: Article

References (16)

1. Matas AJ, Humar A, Gillingham KJ, et al: Five preventable causes of kidney graft loss in the 1990s: A single-center analysis 2002. Kidney Int 62:704, 2002
2. Sunder-Plassmann G, Floth A, Födinger M: Hyperhomocysteinemia in organ transplantation. Curr Opin Urol 10:87, 2000
3. Hankey GJ, Eikelboom JW: Homocysteine and vascular disease. Lancet 354:407, 1999
4. Födinger M, Buchmayer H, Heinz G, et al: Effect of MTHFR 1298 A→C and MTHFR 677C→T genotypes on total homocysteine, folate, and vitamin B12 plasma concentrations in kidney graft recipients. J Am Soc Nephrol 11:1918, 2000
5. Marcucci R, Fedi S, Brunelli T, et al: High cysteine levels in renal transplant recipients. Transplantation 71:746, 2001
6. Marcucci R, Zanazzi M, Bertoni E, et al: Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients. Transplantation 75:1551, 2003
7. Bostom AG, Culleton BF: Hyperhomocysteinemia in chronic renal disease. J Am Soc Nephrol 10:891, 1999
8. van der Put NM, Gabreëls F, Stevens EMB, et al: A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 62:1044, 1998
9. Haddad R, Mendes MA, Höehr NF, et al: Amino acid quantitation in aqueous matrices via trap and release membrane introduction mass spectrometry: homocysteine in human plasma. Analyst 126:1212, 2001
10. Vellasco AP, Haddad R, Eberlin MN, et al: Combined Cysteine & Homocysteine Quantitation in Plasma by Trap & Release Membrane Introduction Mass Spectrometry. Analyst 127: 1050, 2002
11. American Society of Human Genetic/American College of Medical Genetics Test, and Transfer Committee Working Group: Measurement and use of total plasma homocysteine. Am J Hum Gnet 63:1541, 1998
12. Abdel-Rahman SZ, Nouraldeen AM, Ahmed AE: Molecular interaction of 2,3-[14C]-acrylonitrile with DNA in gastric tissues of rat. J Biochem Toxicol 9:121, 1994
13. Yi P, Pogrinbny IP, James SJ: PCR for silmultaneous detection of 677 C→T and 1298 A→C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk. Multiplex: Cancer Letter 181:209, 2002
14. Bostom AG, Gohh RY, Tsai MY, et al: Excess prevalence of fasting and postmethionine loading hyperhomocysteinemia in stable renal transplant recipients. Arterioscler Thromb Vasc Biol 17:1894, 1997
15. Födinger M, Wölfl G, Fischer G, et al: Effect of MTHFR 677C→T on plasma total homocysteine levels in renal graft recipients. Kidney Int 55:1072, 1999
16. Hagen W, Födinger M, Heinz G, et al: Effect of MTHFR genotypes and hyperhomocysteinemia on patient and graft survival in kidney transplant recipients. Kidney Int 59:S253, 2001