Microbial degradation of disinfectants. A new chlorhexidine degradation intermediate (CHDI), CHDI-C, produced by Pseudomonas sp. Strain No. A-3

Journal of Health Science

Volumn 51, Issue 3, 2005, Pages 357-361

  Tanaka, Teruo ^a   Murayama, Sawa ^a   Tuda, Natuki ^a   Nishiyama, Masami ^a   Nakagawa, Kazuko ^a   Matsuo, Yasuko ^a   Isohama, Youichiro ^a   Kido, Yutaka ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Chlorhexidine; Chlorhexidine degradation intermediate; Chlorhexidine degradation intermediate C; Degradation products; Disinfectant; Modified degradation pathway

Indexed keywords

ACETIC ACID ETHYL ESTER; BUTANOL; CHLORHEXIDINE GLUCONATE; SILICA GEL;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; DRUG DEGRADATION; DRUG IDENTIFICATION; DRUG ISOLATION; EXTRACTION; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS; THIN LAYER CHROMATOGRAPHY;

PSEUDOMONAS; PSEUDOMONAS SP.;

EID: 21144457804     PISSN: 13449702     EISSN: None     Source Type: Journal    
DOI: 10.1248/jhs.51.357     Document Type: Article

References (11)

1. Sayama, N. (1981) Microbiological studies on waste water treatment by medical school and hospitals. (III) Treatment of benzalkonium chloride and chlorhexidine. Jpn. J. Hyg., 35, 869-873.
2. Sakagami, Y., Yokoyama, H. and Ose, Y. (1983) Degradation of some disinfectants by activated sludge. Jpn. J. Toxicol. Environ. Health, 29, 342-351.
3. Kido, Y., Yokoyama, H., Uraki, F., Uyeda, M., Tsuruoka, M. and Shibata, M. (1988) Microbial degradation of disinfectants. I. chlorhexidine-degrading bacteria isolated from activated sludge. Jpn. J. Toxicol. Environ. Health, 34, 10-14.
4. Kodama, H., Hashimoto, T., Tsuruoka, M., Kido, Y., Uyeda, M. and Shibata, M. (1988) Microbial degradation of disinfectant IV. Treatment by activated sludge of chlorhexidine. Jpn. J. Toxicol. Environ. Health, 34, 408-413.
5. Kido, Y., Kodama, H., Uraki, F., Uyeda, M., Tsuruoka, M. and Shibata, M. (1988) Microbial degradation of disinfectants. III. Determination of chlorhexidine in waste waters by high-performance liquid chromatography after pretreatment. Jpn. J. Toxicol. Environ. Health, 34, 319-324.
6. Kido, Y., Kodama, H., Uraki, F., Uyeda, M., Tsuruoka, M. and Shibata, M. (1988) Microbial degradation of disinfectants. II. Complete degradation of chlorhexidine. Jpn. J. Toxicol. Environ. Health, 34, 97-101.
7. Kido, Y., Kodama, H., Isohama, Y., Uyeda, M. and Shibata, M. (1990) Microbial degradation of disinfectants. V. A new lipophilic degradation product of chlorhexidine. Jpn. J. Toxicol. Environ. Health, 36, 139-142.
8. Uyeda, M., Shiozaki, T., Yokomizo, K., Suzuki, K., Uraki, F., Tanaka, T. and Kido, Y. (1996) Microbial degradation of disinfectants. Structures of chlorhexidine degradation intermediates, CHDI-B, CHDI-BR and CHDI-D, produced by Pseudomonas sp. Strain No. A-3. Jpn. J. Toxicol. Environ. Health, 42, 121-126.
9. Huston, C. E., Wainwright, P. and Cooke, M. (1982) High-performance liquid chromatographic method for the determination of chlorhexidine. J. Chromatogr., 237, 457-464.
10. Waksman, S. A. and Reilly, H. C. (1945) Agar-streak method for assaying antibiotic substances. Ind. Eng. Chem. Anal. ED., 17, 556-557.
11. Uyeda, M., Shiozaki, T., Enokida, T., Watanabe, K., Komiya, K., Yokomizo, K. and Suzuki, K. (1996) Microbial degradation of Chlorhexidine by Clinical isolates. Jpn. J. Toxicol. Environ. Health, 42, 312-318.