Simple synthesis of deuterium and 13C labeled trifluoromethyl phenyldiazirine derivatives as stable isotope tags for mass spectrometry

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 11, 2004, Pages 1385-1386

  Hashimoto, Makoto ^a   Hatanaka, Yasumaru ^b  

^a OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Diazirine; Photoaffinity label; Stable isotope

Indexed keywords

CARBENE; CARBON 13; CARBONYL DERIVATIVE; DEUTERIUM; FATTY ACID DERIVATIVE; GALACTOSYLCERAMIDE; ISOTOPE; PIPERAZINE DERIVATIVE; TRIFLUOROMETHYLDIAZIRINE; UNCLASSIFIED DRUG; CARBON; DIAZOMETHANE;

ARTICLE; BINDING AFFINITY; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; ISOTOPE LABELING; MASS SPECTROMETRY; REDUCTION; BINDING SITE; DEUTERIUM HYDROGEN EXCHANGE; METABOLISM; METHODOLOGY; SYNTHESIS;

BINDING SITES; CARBON ISOTOPES; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; DIAZOMETHANE; ISOTOPE LABELING; MASS SPECTROMETRY;

EID: 21144450582     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.52.1385     Document Type: Article

References (8)

1. Hatanaka Y., Nakayama H., Kanaoka Y., Rev. Heteroatom Chem., 14, 213-243 (1996).
2. Hatanaka Y., Sadakane Y., Curr. Top. Med. Chem., 2, 271-288 (2002).
3. Gillingham A. K., Koumanov F., Hashimoto M., Holman G. D., "Membrane Transport: A Practical Approach," ed. by Baldwin S. A., Oxford University Press, Oxford, 2000, pp. 193-207.
4. Adam G. C., Sorensen E. J., Cravatt B. F., Mol. Cell Proteomics, 1, 781-790 (2002).
5. Hashimoto M., Hatanaka Y., Nabeta K., Heterocycles, 59, 395-398 (2003).
6. Hatanaka Y., Hashimoto M., Kurihara H., Nakayama H., Kanaoka Y., J. Org. Chem., 59, 383-387 (1994).
7. Hashimoto M., Hatanaka Y., Nabeta K., Bioorg. Med. Chem. Lett., 12, 89-91 (2002).
8. Ishikawa D., Taki T., Methods Enzymol., 312, 145-157 (2000).